PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23394447-7 2012 We found that exposure of BHY cells to nicotine (200 microg/mL for 6 hours) resulted in 2.9-fold induction of COX-2 expression as well as a 4-fold increase in VEGF levels compared with a control group. Nicotine 39-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-115 23394447-8 2012 Pretreatment with celecoxib inhibited nicotine-induced change in the expression of VEGF and COX-2. Nicotine 38-46 mitochondrially encoded cytochrome c oxidase II Homo sapiens 92-97 23394447-9 2012 The results suggest that stimulation of COX-2 and VEGF expression can contribute as important factors in the tumorigenic action of nicotine in oral cancer progression. Nicotine 131-139 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 17254563-9 2007 The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine. Nicotine 107-115 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-40 23394447-0 2012 Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer. Nicotine 10-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 21210228-10 2011 Furthermore, COX-2 signal was induced by nicotine treatment and is involved in nicotine-enhanced fibronectin expression. Nicotine 41-49 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 21210228-10 2011 Furthermore, COX-2 signal was induced by nicotine treatment and is involved in nicotine-enhanced fibronectin expression. Nicotine 79-87 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 19469000-6 2009 RESULTS: Nicotine (100 microg/mL, 200 microg/mL) enhanced TE-13 cells migration and invasion, and increased the protein expression of COX-2 and the activity of MMP-2. Nicotine 9-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 134-139 21677839-7 2011 RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398. Nicotine 9-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 74-79 21677839-7 2011 RESULTS: Nicotine upregulated periostin in gastric cancer cells through a COX-2 dependent pathway, which was blocked by the COX-2-specific inhibitor NS398. Nicotine 9-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 124-129 21261791-3 2011 Recently, we found that nicotine promoted tumor growth through upregulation of the COX-2/prostaglandin E(2) pathway. Nicotine 24-32 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 18849602-9 2009 In cultured human mesangial cells we also demonstrated that nicotine increases COX-2 expression and activity and that COX-2 mediates mesangial cell proliferation in response to nicotine. Nicotine 60-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 79-84 18849602-9 2009 In cultured human mesangial cells we also demonstrated that nicotine increases COX-2 expression and activity and that COX-2 mediates mesangial cell proliferation in response to nicotine. Nicotine 177-185 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 17254563-9 2007 The inhibitors of cyclooxygenase (COX)-2 and protein kinase A (PKA) at 100 microM inhibited the actions of nicotine, suggesting that the endogenous prostaglandin E(2) might be, at least, partially involved the actions of nicotine. Nicotine 221-229 mitochondrially encoded cytochrome c oxidase II Homo sapiens 18-40 16966384-6 2006 It is reported that nicotine induces prostaglandinE2 (PGE(2)) production in PBMC through the up-regulation of cyclooxygenase (COX)-2 expression. Nicotine 20-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-132 17342254-8 2007 These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression. Nicotine 58-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 17342254-8 2007 These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression. Nicotine 138-146 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 17342254-8 2007 These results suggest that LPS enhances the production of nicotine-induced PGE(2) by an increase in COX-2 expression in osteoblasts, that nicotine-LPS-induced PGE2 interacts with the osteoblast Ep4 receptor primarily in autocrine or paracrine mode, and that the nicotine-LPS-induced PGE(2) then decreases ALPase activity and increases M-CSF expression. Nicotine 138-146 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 16966384-8 2006 Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. Nicotine 86-94 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 16966384-8 2006 Consistent with this, we found that COX-2 and PKA inhibitors prevented the effects of nicotine on adhesion molecule expression and cytokine production, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. Nicotine 195-203 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-41 16968406-5 2006 Pretreatment with low-dose nicotine caused inhibition of TNF-alpha, PGE(2), MIP-1alpha and MIP-1alpha production, and mRNA expression of TNF-alpha, MIP-1alpha and MIP-1alpha and COX-2 in lipopolysaccharide (LPS)-activated monocytes. Nicotine 27-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 178-183 16960420-2 2006 Nicotine is reported to induce prostaglandin E(2) (PGE(2)) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression. Nicotine 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 112-134 16960420-4 2006 COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. Nicotine 49-57 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 16960420-4 2006 COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production. Nicotine 102-110 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5