PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34171359-0	2021	Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-kappaB, and AhR.	Nicotine	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-86	
10555165-2	1999	mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal.	Nicotine	65-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31	
34171359-3	2021	Nicotine stimulated CYP1A1 expression via the transcription factors, activator protein 1, nuclear factor-kappa B, and the aryl hydrocarbon receptor (AhR) signaling pathway.	Nicotine	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-88	
30317657-0	2019	Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells.	Nicotine	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-58	
30317657-3	2019	Nicotine stimulated IL-6 expression via the activator protein 1 (AP-1) transcription factor.	Nicotine	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-63	
30317657-3	2019	Nicotine stimulated IL-6 expression via the activator protein 1 (AP-1) transcription factor.	Nicotine	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69	
30317657-7	2019	Our data demonstrate that nicotine induced IL-6 expression, which, in turn, enhanced the invasiveness of endothelial EA.hy926 cells, via activation of the p38 MAPK/AP-1 and ROS/STAT-3 signaling pathways.	Nicotine	26-34	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-168	
20727180-4	2010	RESULTS: While low concentrations of nicotine induced activation of NF-kappaB, Akt, Bcl2, MAPKs, AP1 and IAPs in H1299, it failed to induce NF-kappaB in A549, and compared to H1299, almost 100 times higher concentration of nicotine was required to induce all other survival signals in A549.	Nicotine	37-45	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-100	
35563563-0	2022	Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-kappaB Signaling in Human Gastric Cancer Cells.	Nicotine	28-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122