PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 38334-3 1979 Acetylcholine, nicotine and bethanechol increased, in a dose-related manner, hypothalamic CRH release and content but the maximal responses to bethanechol or nicotine were less than those to acetylcholine.3. Nicotine 15-23 corticotropin releasing hormone Rattus norvegicus 90-93 2897641-5 1988 Further evidence for the cholinergic regulation of the CRH neuron was provided by the findings that both carbachol, a muscarinic receptor agonist, and nicotine, a nicotinic receptor agonist, stimulated IR-rCRH secretion in a dose-dependent fashion. Nicotine 151-159 corticotropin releasing hormone Rattus norvegicus 55-58 38334-3 1979 Acetylcholine, nicotine and bethanechol increased, in a dose-related manner, hypothalamic CRH release and content but the maximal responses to bethanechol or nicotine were less than those to acetylcholine.3. Nicotine 158-166 corticotropin releasing hormone Rattus norvegicus 90-93 19217073-0 2009 Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse. Nicotine 62-70 corticotropin releasing hormone Rattus norvegicus 0-30 27923665-1 2017 We recently found that extracellular administration of nicotine indirectly excited hypothalamic paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) mRNA-expressing neurons. Nicotine 55-63 corticotropin releasing hormone Rattus norvegicus 126-157 27923665-1 2017 We recently found that extracellular administration of nicotine indirectly excited hypothalamic paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) mRNA-expressing neurons. Nicotine 55-63 corticotropin releasing hormone Rattus norvegicus 159-162 27022819-0 2016 Nicotine excites corticotropin-releasing hormone mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 17-48 27022819-1 2016 Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN). Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 101-132 27022819-1 2016 Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN). Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 134-137 27022819-2 2016 However, the mechanism by which nicotine affects the hypothalamic-pituitary-adrenal axis by modulating PVN CRH neuronal activity is currently unclear. Nicotine 32-40 corticotropin releasing hormone Rattus norvegicus 107-110 27022819-5 2016 Under current-clamp recording conditions, application of nicotine (1 muM) induced excitation in 92% (23/25) PVN CRH-mRNA-expressing neurons, which showed a significant increase in the spike firing rate accompanied by a depolarization of the membrane potential. Nicotine 57-65 corticotropin releasing hormone Rattus norvegicus 112-115 27022819-6 2016 Nicotine induced an increase in the spike firing rate of PVN CRH-mRNA-expressing neurons in a concentration-dependent manner. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 61-64 27022819-7 2016 The half-effective concentration (EC50) of nicotine for increasing the spike firing rate of PVN CRH-mRNA-expressing neurons was 1.6 muM. Nicotine 43-51 corticotropin releasing hormone Rattus norvegicus 96-99 27022819-8 2016 Extracellular application of ionotropic glutamate receptor antagonist kynurenic acid (1 mM) abolished the nicotine-induced excitation of PVN CRH-mRNA-expressing neurons. Nicotine 106-114 corticotropin releasing hormone Rattus norvegicus 141-144 27022819-10 2016 Biocytin staining confirmed that the nicotine-sensitive CRH-mRNA-expressing neurons were located in the PVN parvocellular division. Nicotine 37-45 corticotropin releasing hormone Rattus norvegicus 56-59 27022819-11 2016 These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. Nicotine 61-69 corticotropin releasing hormone Rattus norvegicus 93-96 27022819-11 2016 These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. Nicotine 61-69 corticotropin releasing hormone Rattus norvegicus 161-164 27022819-11 2016 These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. Nicotine 138-146 corticotropin releasing hormone Rattus norvegicus 93-96 27022819-11 2016 These results indicated that extracellular administration of nicotine indirectly excited PVN CRH-mRNA-expressing neurons, suggesting that nicotine modulated PVN CRH secretion by enhancement of both the presynaptic action potential drive and quantal glutamate release. Nicotine 138-146 corticotropin releasing hormone Rattus norvegicus 161-164 20202080-2 2010 Nicotine self-administration alters neuropeptide expression in corticotropin-releasing factor (CRF) neurons within paraventricular nucleus (PVN) and increases PVN responsiveness to norepinephrine during mild footshock stress. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 63-93 20117222-9 2010 Consistent with our in vivo and earlier in vitro studies, nicotine added to the hypothalamus tissue bath significantly increased HPA responses in a sex- and dose-dependent manner: Males had greater AVP responses than did females, and females had greater CRH responses than did males. Nicotine 58-66 corticotropin releasing hormone Rattus norvegicus 254-257 31614362-0 2020 Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in female versus male rats. Nicotine 110-118 corticotropin releasing hormone Rattus norvegicus 18-48 27461514-4 2016 Here we investigated whether the overexpression of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis (BNST) diminishes nicotine withdrawal symptoms in rats. Nicotine 149-157 corticotropin releasing hormone Rattus norvegicus 51-81 24157491-8 2014 Adolescent nicotine pretreatment enhanced c-fos mRNA expression in corticotropin releasing factor (CRF) cells of the paraventricular nucleus, and enhancement of penile erection was blocked by the CRF-1 receptor antagonist, CP 376,396. Nicotine 11-19 corticotropin releasing hormone Rattus norvegicus 67-97 19217073-2 2009 Previous research has shown that blockade of corticotropin-releasing factor (CRF) receptors with a nonspecific CRF1/CRF2 receptor antagonist prevents the deficit in brain reward function associated with nicotine withdrawal and stress-induced reinstatement of extinguished nicotine-seeking in rats. Nicotine 203-211 corticotropin releasing hormone Rattus norvegicus 45-75 19217073-2 2009 Previous research has shown that blockade of corticotropin-releasing factor (CRF) receptors with a nonspecific CRF1/CRF2 receptor antagonist prevents the deficit in brain reward function associated with nicotine withdrawal and stress-induced reinstatement of extinguished nicotine-seeking in rats. Nicotine 272-280 corticotropin releasing hormone Rattus norvegicus 45-75 19429100-0 2009 Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 105-135 19145226-0 2009 Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Nicotine 147-155 corticotropin releasing hormone Rattus norvegicus 0-30 19145226-2 2009 Previous research has shown that an increased central release of corticotropin-releasing factor (CRF) at least partly mediates the deficit in brain reward function associated with nicotine withdrawal in rats. Nicotine 180-188 corticotropin releasing hormone Rattus norvegicus 65-95 17921249-3 2007 We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF(1) receptors. Nicotine 92-100 corticotropin releasing hormone Rattus norvegicus 195-225 17976662-3 2007 The aim of these experiments was to investigate the role of corticotropin-releasing factor (CRF) and norepinephrine in stress-induced reinstatement of extinguished nicotine-seeking behavior. Nicotine 164-172 corticotropin releasing hormone Rattus norvegicus 60-90 16943772-2 2007 It has been hypothesized that cessation of nicotine administration results in the activation of brain corticotropin-releasing factor (CRF) systems that leads to the negative affective state of withdrawal. Nicotine 43-51 corticotropin releasing hormone Rattus norvegicus 102-132 10213914-10 1999 Nicotine (10(-7) M) also stimulated CRH release and this stimulation was completely blocked by 10(-6) M but not by 10(-7) M of the nicotinic receptor blocker, hexamethonium (HEX). Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 36-39 16311047-8 2006 In vitro CRH, ACTH, and CORT responses to nicotine were significantly increased at 10 min and returned to baseline by 30 min, the CRH and ACTH responses from female tissues being greater than responses from male tissues. Nicotine 42-50 corticotropin releasing hormone Rattus norvegicus 9-12 16311047-8 2006 In vitro CRH, ACTH, and CORT responses to nicotine were significantly increased at 10 min and returned to baseline by 30 min, the CRH and ACTH responses from female tissues being greater than responses from male tissues. Nicotine 42-50 corticotropin releasing hormone Rattus norvegicus 130-133 16204770-7 2005 CRH antagonist almost abolished the nicotine-induced hormone responses and vasopressin antagonist reduced ACTH secretion. Nicotine 36-44 corticotropin releasing hormone Rattus norvegicus 0-3 16204770-13 2005 CRH and vasopressin of the hypothalamic paraventricular nucleus may be involved in the nicotine induced alterations of HPA axis activity. Nicotine 87-95 corticotropin releasing hormone Rattus norvegicus 0-3 12669178-0 2003 Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Nicotine 77-85 corticotropin releasing hormone Rattus norvegicus 0-30 12120902-3 2002 Nicotine may stimulate indirectly the hypothalamic paraventricular nucleus, the site of the corticotropin-releasing hormone (CRH) neurons which activates ACTH release. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 92-123 12120902-3 2002 Nicotine may stimulate indirectly the hypothalamic paraventricular nucleus, the site of the corticotropin-releasing hormone (CRH) neurons which activates ACTH release. Nicotine 0-8 corticotropin releasing hormone Rattus norvegicus 125-128 10622280-0 1999 Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line. Nicotine 62-70 corticotropin releasing hormone Rattus norvegicus 14-44 12637038-0 2003 The effects of corticotropin-releasing factor on the cortical EEG are reduced following adolescent nicotine exposure. Nicotine 99-107 corticotropin releasing hormone Rattus norvegicus 15-45 8593811-1 1996 Systemically administered nicotine elicits ACTH release indirectly by acting on neurons in brainstem catecholaminergic regions known to send afferent projections to the paraventricular nucleus of the hypothalamus (PVN), the site of CRH neurons involved in initiating ACTH secretion. Nicotine 26-34 corticotropin releasing hormone Rattus norvegicus 232-235 9549051-3 1997 Other CRH neurons throughout the brain also are involved in coordinating aspects of the stress response, but very little is known about the effect of nicotine on CRH neurons in extrahypothalamic regions that are involved in the autonomic and behavioral responses to stress. Nicotine 150-158 corticotropin releasing hormone Rattus norvegicus 162-165 9549051-4 1997 The current study sought to determine the extent of nicotinic activation of extrahypothalamic CRH neurons, since these neurons may be involved in mediating the central effects of nicotine. Nicotine 179-187 corticotropin releasing hormone Rattus norvegicus 94-97 9549051-8 1997 In all of these areas, nicotine activated CRH neurons in a dose-dependent manner, showing differential sensitivity and efficacy with respect to region. Nicotine 23-31 corticotropin releasing hormone Rattus norvegicus 42-45 9549051-9 1997 CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). Nicotine 86-94 corticotropin releasing hormone Rattus norvegicus 4-7 9549051-9 1997 CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). Nicotine 86-94 corticotropin releasing hormone Rattus norvegicus 103-106 9549051-9 1997 CNA CRH neurons were most responsive and were maximally stimulated by the low dose of nicotine (62% of CRH neurons were cFos+, compared to 10-27% of the CRH population in other regions, including the PVN). Nicotine 86-94 corticotropin releasing hormone Rattus norvegicus 103-106 9549051-13 1997 These results indicate that the effect(s) of nicotine on the brain may be mediated, in part, by the selective activation of specific extrahypothalamic regions containing CRH neurons that also are involved in autonomic and behavioral responses to stress. Nicotine 45-53 corticotropin releasing hormone Rattus norvegicus 170-173 9549051-14 1997 The large fraction of CRH neurons responding to the low dose of nicotine in the CNA suggests that this limbic region may be particularly important in mediating these CNS effects of nicotine. Nicotine 64-72 corticotropin releasing hormone Rattus norvegicus 22-25 9549051-14 1997 The large fraction of CRH neurons responding to the low dose of nicotine in the CNA suggests that this limbic region may be particularly important in mediating these CNS effects of nicotine. Nicotine 181-189 corticotropin releasing hormone Rattus norvegicus 22-25