PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34963197-0	2022	Administration of brain-derived neurotrophic factor in the ventral tegmental area produces a switch from a nicotine nondependent D1R-mediated motivational state to a nicotine dependent-like D2R-mediated motivational state.	Nicotine	166-174	dopamine receptor D2	Mus musculus	190-193	
15312165-6	2004	Nicotine at a low concentration (1 microm) activated dopamine D2 receptor signaling in striatopallidal/indirect pathway neurons, likely by activating alpha4beta2* nAChRs at dopaminergic terminals.	Nicotine	0-8	dopamine receptor D2	Mus musculus	53-73	
2657481-5	1989	When nicotine was administered after MPTP, their separate effects could be seen in that both the D1 and D2 dopamine receptor ligand binding activities were increased and that nicotine elevated the ratio of D1/D2 receptor binding activities in MPTP-treated mice.	Nicotine	5-13	dopamine receptor D2	Mus musculus	104-124	
2522303-3	1989	We investigated the effects of 6-week continuous nicotine intake on the neuroleptic (haloperidol)-induced increase in murine striatal D2-dopamine receptor density.	Nicotine	49-57	dopamine receptor D2	Mus musculus	134-154	
31129809-0	2019	Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference.	Nicotine	50-58	dopamine receptor D2	Mus musculus	16-36	
33411237-11	2021	Taken together, these results indicate that impaired D2R signaling due to lack of FABP3 may affect D1R and c-Fos signaling and underlie nicotine-induced CPP behaviors.	Nicotine	136-144	dopamine receptor D2	Mus musculus	53-56	
31129809-3	2019	Since reward signaling is mediated by dopamine receptors, we hypothesized that the dopamine D2 receptor (D2R), in part, mediates the synaptic modulation of nicotine-induced conditioned place preference (CPP) in addition to dopamine D1 receptor.	Nicotine	156-164	dopamine receptor D2	Mus musculus	83-103	
31129809-8	2019	Taken together, in addition to dopamine D1 receptor signaling, dopamine D2 receptor signaling is critical for induction of nicotine-induced CPP in mice.	Nicotine	123-131	dopamine receptor D2	Mus musculus	63-83	
30325916-11	2018	Analysis of epigenetic changes in the spermatozoa of the nicotine-exposed male founders (F0) showed significant changes in global DNA methylation and DNA methylation at promoter regions of the dopamine D2 receptor gene.	Nicotine	57-65	dopamine receptor D2	Mus musculus	193-213	
23954803-1	2013	Alpha7 nicotinic acetylcholine receptors (alpha7nAChRs) mediate nicotine-induced burst-firing of dopamine neurons in the ventral tegmental area (VTA), a limbic brain region critically involved in reward and in dopamine D2 receptor (D2R)-related cortical dysfunctions associated with psychosis.	Nicotine	64-72	dopamine receptor D2	Mus musculus	210-230	
28462940-4	2017	We used whole-cell patch clamp recording to investigate the effect of chronic nicotine (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in the indirect, striatopallidal pathway in dorsolateral striatum.	Nicotine	78-86	dopamine receptor D2	Mus musculus	120-140	
27170121-9	2016	Here, we show that chronic nicotine (cNIC) treatment or specific deletion of beta2 nicotinic receptor subunits in dopamine neurons mitigates aberrant motor learning induced by dopamine D2 receptor (D2R) blockade in mice.	Nicotine	27-35	dopamine receptor D2	Mus musculus	176-196