PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15037618-6	2004	Treatment of cells with PKC inhibitor (staurosporine), MEK-specific inhibitor (PD98059), PI3 kinase inhibitor (LY294002), or PKA inhibitor (H89) blocks the nicotine-induced Bad phosphorylation that is associated with enhanced apoptotic cell death.	Nicotine	156-164	mitogen-activated protein kinase kinase 7	Homo sapiens	55-58	
22898831-0	2013	Nicotine up-regulated 4-1BBL expression by activating Mek-PI3K pathway augments the efficacy of bone marrow-derived dendritic cell vaccination.	Nicotine	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	54-57	
29039603-0	2017	Blockade of alpha7 nicotinic acetylcholine receptors inhibit nicotine-induced tumor growth and vimentin expression in non-small cell lung cancer through MEK/ERK signaling way.	Nicotine	61-69	mitogen-activated protein kinase kinase 7	Homo sapiens	153-156	
29039603-8	2017	Furthermore, under the stimulation of nicotine, the MEK/ERK signaling pathway was found to be inhibited when cells were treated with an antagonist of alpha7nAChR or an inhibitor of MEK.	Nicotine	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	52-55	
29039603-8	2017	Furthermore, under the stimulation of nicotine, the MEK/ERK signaling pathway was found to be inhibited when cells were treated with an antagonist of alpha7nAChR or an inhibitor of MEK.	Nicotine	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	181-184	
27409670-4	2016	Meanwhile, nicotine induced activation of MEK/ERK signaling in NSCLC cells; alpha7-nAChR antagonism or MEK/ERK signaling pathway inhibition suppressed NSCLC cell invasion and EMT marker expression.	Nicotine	11-19	mitogen-activated protein kinase kinase 7	Homo sapiens	42-45	
27409670-5	2016	These results indicate that nicotine induces NSCLC cell invasion, migration, and EMT; the effects are mediated by alpha7-nAChRs and involve MEK/ERK signaling pathway.	Nicotine	28-36	mitogen-activated protein kinase kinase 7	Homo sapiens	140-143	
22898831-8	2013	Importantly, nicotine-induced 4-1BBL up-regulation could be decreased by the usage of Mek-PI3K pathway kinase inhibitors.	Nicotine	13-21	mitogen-activated protein kinase kinase 7	Homo sapiens	86-89	
22898831-9	2013	The pre-treatment of Mek-p38-PI3K kinase inhibitors could obviously abolish nicotine-augmented DCs-dependent T cell proliferation.	Nicotine	76-84	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24