PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35131329-6	2022	In vitro, nicotine increased the levels of alpha5-nAChR, p-STAT3, and NLRP3 inflammasome expression, accompanied by the expression of caspase-1, IL-1beta and IL-18.	Nicotine	10-18	interleukin 18	Mus musculus	158-163	
33321327-8	2021	Nicotine promoted pyroptosis in RAW264.7 cells, as evidenced by increased expression of cleaved Caspase1, NLRP3, IL-1beta, IL-18, and elevated LDH release.	Nicotine	0-8	interleukin 18	Mus musculus	123-128	
21239632-4	2011	An analysis of the phenotype of isolated brain microvessels after nicotine exposure indicated higher expression of inflammatory mediators, cytokines (IL-1beta, TNF-alpha, and IL-18), chemokines (CCL2 and CX(3)CL1), and adhesion molecules (ICAM-1, VCAM-1, and P-selectins), and this was accompanied by enhanced leukocyte infiltration into brain during ischemia/reperfusion (P < 0.01).	Nicotine	66-74	interleukin 18	Mus musculus	175-180	
35565726-4	2022	Here, we reported that nicotine promoted hepatocyte pyroptosis, as evidenced by the elevation of propidium iodide (PI)-positive cells, the activation of Caspase-1 and gasdermin D (GSDMD), the enhanced expression of NOD-like receptor containing pyrin domain 3 (NLRP3) and the increased release of lactate dehydrogenase (LDH), interleukin (IL)-1beta and IL-18.	Nicotine	23-31	interleukin 18	Mus musculus	352-357