PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28393191-4 2017 TSA also induces an elevated expression of cell cycle inhibitory protein p21Cip1 along with a decrease in cell cycle regulatory protein cyclin D1. trichostatin A 0-3 cyclin D1 Homo sapiens 136-145 31289542-6 2019 The expression of EGFR and STAT3 was downregulated following TSA treatment, and cell cycle arrest was induced by downregulating the expression of cyclin D1 and CDK6, and via retinoblastoma protein phosphorylation. trichostatin A 61-64 cyclin D1 Homo sapiens 146-155 31289542-7 2019 Furthermore, the transcription of cyclin D1 and CDK6 was suppressed by TSA. trichostatin A 71-74 cyclin D1 Homo sapiens 34-43 29393444-5 2018 This over-proliferative activity induced by TSA may be associated with abnormal activation of JAK2/STAT3 signaling, which can be strengthened by interleukin-6 (IL-6), a STAT3-upstream inducer, resulting in enhanced expression of STAT3-downstream target genes including c-Myc, c-Src, HIF-1alpha, and CCND1. trichostatin A 44-47 cyclin D1 Homo sapiens 299-304 33649777-8 2021 In addition, treatment with TSA suppressed cancer cell proliferation via G2/M arrest, as well as upregulating p21 and downregulating cyclin D1 expression. trichostatin A 28-31 cyclin D1 Homo sapiens 133-142 30902084-8 2019 TSA reduced PCNA, cyclin D1, cyclin E1, CDK2, p16 and p21 expressions and stimulated CDK6 levels. trichostatin A 0-3 cyclin D1 Homo sapiens 18-27 30334455-6 2018 TSA treatment leads to decreased expression of CYCLIN D1, CDK4, CDK6 and BCL-XL, but increased P21 expression. trichostatin A 0-3 cyclin D1 Homo sapiens 47-56 30214285-5 2018 Results: TSA exerted a time and dose-dependent cytotoxicity on MM cell lines, and suppressed the proliferation of MM cells and induced an upregulation of p21 protein accompanied by a decreased expression of cyclin D1. trichostatin A 9-12 cyclin D1 Homo sapiens 207-216 24280698-1 2012 The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators. trichostatin A 56-70 cyclin D1 Homo sapiens 158-167 26287365-8 2015 TSA and SAHA promoted apoptosis of SGC-996 cells, down-regulated the expression of cyclin D1, c-Myc and Bmi1, and decreased the phosphorylation of AKT, mTOR p70S6K1, S6 and 4E-BP1. trichostatin A 0-3 cyclin D1 Homo sapiens 83-92 24665856-8 2014 In addition, DAC, TSA, and gemcitabine+cisplatin combination caused an increase in GSK3beta mRNA levels, which in turn significantly decreased CCND1 mRNA levels. trichostatin A 18-21 cyclin D1 Homo sapiens 143-148 23013422-3 2013 We observed that TSA increased the expression of proliferating cell nuclear antigen and cyclin D1 in hDPSCs at a certain concentration and the activation of JNK/c-Jun pathway was essential for TSA-dependent hDPSC proliferation. trichostatin A 17-20 cyclin D1 Homo sapiens 88-97 25057056-7 2014 The expressions of beta-catenin, H3K9 and Bax proteins were significantly increased and CyclinD1, HDAC1, and HDAC3 protein expressions decreased in TSA-treated cells, but the expressions of HDAC1 and HDAC3 mRNAs showed no significant changes. trichostatin A 148-151 cyclin D1 Homo sapiens 88-96 23745024-3 2013 Real time polymerase chain reaction and Western blotting were used to observe expression changes in p21, p53, Bax, Bcl-2, CDK2, and CyclinD1 in gastric cancer cells exposed to TSA. trichostatin A 176-179 cyclin D1 Homo sapiens 132-140 23745024-7 2013 p21, p53 and Bax gene expression levels in AGS cells were increased with TSA treatment duration; Bcl-2, CDK2, and CyclinD1 gene expression levels were decreased with TSA treatment duration. trichostatin A 166-169 cyclin D1 Homo sapiens 114-122 22290509-6 2013 The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression. trichostatin A 85-88 cyclin D1 Homo sapiens 163-172 24280698-1 2012 The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators. trichostatin A 72-75 cyclin D1 Homo sapiens 158-167 24280698-5 2012 Conversely, cyclin D1 is upregulated by butyrate and inhibited by TSA. trichostatin A 66-69 cyclin D1 Homo sapiens 12-21 24280698-6 2012 Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression. trichostatin A 169-172 cyclin D1 Homo sapiens 107-116 24280698-6 2012 Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression. trichostatin A 169-172 cyclin D1 Homo sapiens 176-185 24280698-6 2012 Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression. trichostatin A 169-172 cyclin D1 Homo sapiens 176-185 24280698-7 2012 Disparity in butyrate- and TSA-induced cyclin D1 may influence transcriptional regulation of genes that are associated with changes in cellular morphology/cellular effects that these HDACi confer on VSMC, as a transcriptional modulator. trichostatin A 27-30 cyclin D1 Homo sapiens 39-48 17407970-9 2007 Nevertheless Dip1 markedly inhibited the stimulation of cyclin D1 promoter activity obtained with trichostatin A [1], an inhibitor of HDAC. trichostatin A 98-112 cyclin D1 Homo sapiens 56-65 20821348-9 2011 Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation. trichostatin A 0-14 cyclin D1 Homo sapiens 47-56 20821348-9 2011 Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation. trichostatin A 0-14 cyclin D1 Homo sapiens 113-122 20178884-8 2010 Treatment with trichostatin A or apicidine suppressed the proliferation in all cell lines examined, in association with increased expression of p21 and down-regulation of cyclin D1 and cyclin A expression. trichostatin A 15-29 cyclin D1 Homo sapiens 171-180 18949380-5 2008 In addition, TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells. trichostatin A 13-16 cyclin D1 Homo sapiens 59-68 25961258-3 2011 RESULTS: In estrogen receptor alpha (ERalpha)-positive MCF-7 and T47-D cells, TSA induced a long-term degradation of cyclin A and a proteasome-dependent loss of ERalpha and cyclin D1, allowed derepression of p21WAF1/CIP1, HDAC1 and RhoB GTPase, concomitantly with blockade in G2/M of the cell cycle and apoptosis induction. trichostatin A 78-81 cyclin D1 Homo sapiens 173-182 18424709-4 2008 TSA treatment inhibited the GM-CSF-dependent proliferation of macrophages by interfering with c-myc and cyclin D1 expression. trichostatin A 0-3 cyclin D1 Homo sapiens 104-113 16504004-0 2006 Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. trichostatin A 31-45 cyclin D1 Homo sapiens 74-83 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 64-78 cyclin D1 Homo sapiens 138-147 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 64-78 cyclin D1 Homo sapiens 200-209 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 64-78 cyclin D1 Homo sapiens 216-221 16503970-3 2006 We have demonstrated previously, that TSA induces the ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells. trichostatin A 38-41 cyclin D1 Homo sapiens 89-98 16503970-4 2006 Additional studies were initiated in order to further investigate the effect of TSA on cyclin D1 regulation using sub-cellular fractionation techniques. trichostatin A 80-83 cyclin D1 Homo sapiens 87-96 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 80-83 cyclin D1 Homo sapiens 138-147 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 80-83 cyclin D1 Homo sapiens 200-209 16504004-4 2006 We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription. trichostatin A 80-83 cyclin D1 Homo sapiens 216-221 16504004-5 2006 TSA treatment also resulted in accumulation of polyubiquitylated GFP-cyclin D1 species and reduced levels of the recombinant protein within the nucleus. trichostatin A 0-3 cyclin D1 Homo sapiens 69-78 16504004-6 2006 RESULTS: Here we provide further evidence for TSA-induced ubiquitin-dependent degradation of cyclin D1 and demonstrate that GSK3beta-mediated nuclear export facilitates this activity. trichostatin A 46-49 cyclin D1 Homo sapiens 93-102 16504004-7 2006 Our observations suggest that TSA treatment results in enhanced cyclin D1 degradation via the GSK3beta/CRM1-dependent nuclear export/26S proteasomal degradation pathway in MCF-7 cells. trichostatin A 30-33 cyclin D1 Homo sapiens 64-73 16504004-8 2006 CONCLUSION: We have demonstrated that rapid TSA-induced cyclin D1 degradation in MCF-7 cells requires GSK3beta-mediated Thr-286 phosphorylation and the ubiquitin-dependent 26S proteasome pathway. trichostatin A 44-47 cyclin D1 Homo sapiens 56-65 15870300-4 2005 The hypoacetylation of H3 at the cyclin D1 promoter was reversed by treatment with trichostatin A (TSA), a histone deacetylase inhibitor, or by expression of TAF1 proteins that retain HAT activity. trichostatin A 83-97 cyclin D1 Homo sapiens 33-42 15870300-4 2005 The hypoacetylation of H3 at the cyclin D1 promoter was reversed by treatment with trichostatin A (TSA), a histone deacetylase inhibitor, or by expression of TAF1 proteins that retain HAT activity. trichostatin A 99-102 cyclin D1 Homo sapiens 33-42 15870300-6 2005 Treatment with TSA restored full activity to the cyclin D1-c-fos chimera at 39.5 degrees C. In vivo genomic footprinting experiments indicate that protein-DNA interactions at the Sp1 sites of the cyclin D1 promoter were compromised at 39.5 degrees C in ts13 cells. trichostatin A 15-18 cyclin D1 Homo sapiens 49-58 15870300-6 2005 Treatment with TSA restored full activity to the cyclin D1-c-fos chimera at 39.5 degrees C. In vivo genomic footprinting experiments indicate that protein-DNA interactions at the Sp1 sites of the cyclin D1 promoter were compromised at 39.5 degrees C in ts13 cells. trichostatin A 15-18 cyclin D1 Homo sapiens 196-205 15755876-8 2005 Moreover, a chromatin immunoprecipitation assay shows that trichostatin A treatment inhibits endogenous cyclin D1 gene transcription by preventing p65 binding to the cyclin D1 promoter. trichostatin A 59-73 cyclin D1 Homo sapiens 104-113 15755876-6 2005 Trichostatin A inhibits cyclin D1 expression in a NF-kappaB-dependent manner in JB6 cells. trichostatin A 0-14 cyclin D1 Homo sapiens 24-33 15755876-8 2005 Moreover, a chromatin immunoprecipitation assay shows that trichostatin A treatment inhibits endogenous cyclin D1 gene transcription by preventing p65 binding to the cyclin D1 promoter. trichostatin A 59-73 cyclin D1 Homo sapiens 166-175 15755876-14 2005 Together, the results provide the first demonstration that HDAC inhibitor trichostatin A inhibits cyclin D1 gene transcription through targeting transcription factor NF-kappaB/p65 DNA binding. trichostatin A 74-88 cyclin D1 Homo sapiens 98-107 15585645-0 2004 Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. trichostatin A 30-44 cyclin D1 Homo sapiens 143-152 15585645-7 2004 Taken together, our data show that TSA effectively induces cyclin D1 down-regulation through both ERalpha-dependent and ERalpha-independent mechanisms, providing an important new strategy for combating resistance to antiestrogens. trichostatin A 35-38 cyclin D1 Homo sapiens 59-68 15585645-5 2004 Cyclin D1 degradation involved Skp2/p45, a regulatory component of the Skp1/Cullin/F-box complex; silencing SKP2 gene expression by RNA interference stabilized cyclin D1 and abrogated the cyclin D1 down-regulation response to TSA. trichostatin A 226-229 cyclin D1 Homo sapiens 0-9 12684681-4 2003 When we examined the effects of this drug on ACHN cells, trichostatin decreased the levels of CDK4, CDK6, cyclin D1 and cyclin A proteins. trichostatin A 57-69 cyclin D1 Homo sapiens 106-115 15179185-5 2004 Furthermore, TSA treatment led to reduction in cyclin D1 whereas cyclin D3 accumulated, the latter due to increased protein stability. trichostatin A 13-16 cyclin D1 Homo sapiens 47-56 10716680-11 2000 Trichostatin A showed similar effects on cyclin D1 and D3. trichostatin A 0-14 cyclin D1 Homo sapiens 41-50 14526425-8 2003 Trichostatin A showed similar effects on cyclin D1 and D3 as sodium butyrate. trichostatin A 0-14 cyclin D1 Homo sapiens 41-50