PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30649504-2 2019 We recently showed that inhibitors of DNA methyltransferase 5-aza-2"-deoxycytidine (5-Aza) and histone deacetylase trichostatin A (TSA) increased BrO3- nephrotoxicity whereas altering the expression of the cyclin-dependent kinase inhibitor p21. trichostatin A 115-129 H3 histone pseudogene 16 Homo sapiens 240-243 30649504-2 2019 We recently showed that inhibitors of DNA methyltransferase 5-aza-2"-deoxycytidine (5-Aza) and histone deacetylase trichostatin A (TSA) increased BrO3- nephrotoxicity whereas altering the expression of the cyclin-dependent kinase inhibitor p21. trichostatin A 131-134 H3 histone pseudogene 16 Homo sapiens 240-243 28993733-0 2017 LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells. trichostatin A 104-116 H3 histone pseudogene 16 Homo sapiens 75-78 29303911-5 2018 RESULTS: Treatment of PANC-1 cells over 4 days with 0.5 muM TSA restored cellular differentiation, inhibited proliferation, and enhanced p21 protein expression. trichostatin A 60-63 H3 histone pseudogene 16 Homo sapiens 137-140 30318011-10 2019 CONCLUSION: The combination treatment of p53-null HL-60 cells with DNA-damaging agent CLB and HDACIs NaBu and TSA triggered additive to synergistic effects on apoptosis and upregulated BCL6 and p21 expression. trichostatin A 110-113 H3 histone pseudogene 16 Homo sapiens 194-197 28993733-5 2017 Knockdown of uc002mbe.2 prohibited TSA-induced G2/M cell cycle arrest, p21 induction, and apoptosis of Huh7 cells and reversed the TSA-mediated decrease in p-AKT. trichostatin A 35-38 H3 histone pseudogene 16 Homo sapiens 71-74 28993733-9 2017 In addition, the ability of TSA to reduce hnRNPA2B1 and p-AKT levels and induce p21 in the xenograft tumors was prevented by uc002mbe.2 knockdown. trichostatin A 28-31 H3 histone pseudogene 16 Homo sapiens 80-83 28993733-10 2017 Therefore, the interaction of uc002mbe.2 and hnRNPA2B1 in mediating AKT deactivation and p21 induction is involved in the cytostatic effect of trichostatin in liver cancer cells. trichostatin A 143-155 H3 histone pseudogene 16 Homo sapiens 89-92 26559563-5 2015 Levels of p21 mRNA and protein were significantly increased by butyrate and TSA (~threefold and 4.5-fold, respectively, 24 h) in non-transfected but not in miR-106b transfected LT97 cells. trichostatin A 76-79 H3 histone pseudogene 16 Homo sapiens 10-13 27687545-8 2016 The pan-HDAC inhibitors trichostatin A and suberanilohydroxamic acid and the HDAC6-specific inhibitor tubacin inhibited PC3-PR proliferation and increased expression of p21 and acetylated alpha-tubulin in a manner similar to CTX. trichostatin A 24-38 H3 histone pseudogene 16 Homo sapiens 169-172 27543423-9 2016 The effect of 5-Aza and TSA on DNA methyltransferase and histone deacetylase activity, respectively, was confirmed by assessing the methylation and acetylation of the CDK inhibitor p21. trichostatin A 24-27 H3 histone pseudogene 16 Homo sapiens 181-184 27716272-0 2016 The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. trichostatin A 34-48 H3 histone pseudogene 16 Homo sapiens 125-128 27716272-12 2016 Furthermore, siRNA assays were performed to analyse the role of p21 and p53 on TSA-mediated anti-lymphangiogenic effects. trichostatin A 79-82 H3 histone pseudogene 16 Homo sapiens 64-67 27716272-15 2016 Additionally, we observed that p21 protein accumulated in cellular nuclei after treatment with TSA. trichostatin A 95-98 H3 histone pseudogene 16 Homo sapiens 31-34 27716272-20 2016 Interestingly, siRNA-mediated p21 depletion almost completely reversed the anti-proliferative effects of TSA in LEC. trichostatin A 105-108 H3 histone pseudogene 16 Homo sapiens 30-33 24676336-12 2014 For the TSA+DAC group, higher levels of p53, p21, cyclin B1 and Chk1 were detected, concomitant with lower levels of CDK1, when compared to the control group. trichostatin A 8-11 H3 histone pseudogene 16 Homo sapiens 45-48 25281925-3 2014 In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. trichostatin A 43-57 H3 histone pseudogene 16 Homo sapiens 89-92 25281925-3 2014 In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. trichostatin A 59-62 H3 histone pseudogene 16 Homo sapiens 89-92 25036040-10 2014 Trichostatin A and MS-275 (both HDAC inhibitors) inhibited the downstream pathway of HDAC1 and caused cell growth arrest via activation of p53 and p21; the effects of digoxigenin were totally opposite. trichostatin A 0-14 H3 histone pseudogene 16 Homo sapiens 147-150 25371069-6 2015 Simultaneously, p21 and ATF3 expression levels were upregulated and downregulated upon TSA stimulation, respectively. trichostatin A 87-90 H3 histone pseudogene 16 Homo sapiens 16-19 25371069-10 2015 Collectively, these data demonstrate that ATF3 acts as an essential negative regulator of TSA-induced cell growth inhibition through interfering with TSA-induced p21 activation. trichostatin A 90-93 H3 histone pseudogene 16 Homo sapiens 162-165 25371069-10 2015 Collectively, these data demonstrate that ATF3 acts as an essential negative regulator of TSA-induced cell growth inhibition through interfering with TSA-induced p21 activation. trichostatin A 150-153 H3 histone pseudogene 16 Homo sapiens 162-165 22290509-6 2013 The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression. trichostatin A 85-88 H3 histone pseudogene 16 Homo sapiens 136-139 23028803-7 2012 p21 and BIM, which were identified as target genes of miR-106b-93-25 cluster, increased in TSA treated tumor cells and were responsible for cell cycle arrest and apoptosis. trichostatin A 91-94 H3 histone pseudogene 16 Homo sapiens 0-3 23028803-8 2012 We further identified MYC as a regulator of miR-106b-93-25 cluster and demonstrated its down-regulation in the presence of TSA resulted in the reduction of miR-106b-93-25 cluster and up-regulation of p21 and BIM. trichostatin A 123-126 H3 histone pseudogene 16 Homo sapiens 200-203 19639184-3 2009 This MLH1-deficient subline selected for TSA resistance by stepwise exposures to increasing TSA concentrations exhibited failure in the accumulation of acetylated histones, in p21 induction, and in apoptosis activation. trichostatin A 92-95 H3 histone pseudogene 16 Homo sapiens 176-179 20450546-6 2010 The expression of p21 protein was significantly up-regulated and the expression of phosphorylation ERK was significantly down-regulated after A549 cells were treated with TSA. trichostatin A 171-174 H3 histone pseudogene 16 Homo sapiens 18-21 21858218-5 2011 p21, an important regulator of cell senescence, was induced ~3 fold in HCT116 PTTG1(-/-) cells upon doxorubicin or Trichostatin A treatment. trichostatin A 115-129 H3 histone pseudogene 16 Homo sapiens 0-3 21858218-8 2011 PTTG1 also regulated SW620 colon cancer cells response to doxorubicin and TSA mediated by p21. trichostatin A 74-77 H3 histone pseudogene 16 Homo sapiens 90-93 20952396-3 2010 We show here that induction of p21 by trichostatin A involves MAP kinase signaling. trichostatin A 38-52 H3 histone pseudogene 16 Homo sapiens 31-34 17376583-0 2008 Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. trichostatin A 31-45 H3 histone pseudogene 16 Homo sapiens 93-96 18949380-9 2008 Overall, the TsA-activated ERK pathway plays an important role in cell cycle arrest and apoptosis through the ERK-dependent induction of p21 in Ras-related human cancer cells. trichostatin A 13-16 H3 histone pseudogene 16 Homo sapiens 137-140 18949013-8 2009 After treatment with TSA, expression of the cell cycle kinase inhibitor p21 was upregulated and the cell cycle was arrested at G1. trichostatin A 21-24 H3 histone pseudogene 16 Homo sapiens 72-75 18645003-1 2008 Previous studies comparing the effects of two histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and CG-1521, have shown that these compounds selectively inhibit HDAC and induce differentially acetylated p53 isoforms and assembly of mutually exclusive transcriptional complexes on the p21 promoter. trichostatin A 85-99 H3 histone pseudogene 16 Homo sapiens 294-297 18645003-1 2008 Previous studies comparing the effects of two histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and CG-1521, have shown that these compounds selectively inhibit HDAC and induce differentially acetylated p53 isoforms and assembly of mutually exclusive transcriptional complexes on the p21 promoter. trichostatin A 101-104 H3 histone pseudogene 16 Homo sapiens 294-297 18645003-2 2008 To determine whether the differential transcriptional regulation seen in p21 gene is unique or whether it is representative of the genome-wide effects of these two HDAC inhibitors, we have used microarray and Ingenuity pathway analysis to compare the effects of TSA and CG-1521 on gene expression on LNCaP cells. trichostatin A 262-265 H3 histone pseudogene 16 Homo sapiens 73-76 17376583-1 2008 OBJECTIVE: Following our observation that histone deacetylase inhibitors (HDACIs) trichostatin A (TSA) and valproic acid (VPA) can suppress proliferation of endometrial stromal cells, we sought to determine whether TSA and VPA do so by inducing cell cycle arrest and p21 expression. trichostatin A 98-101 H3 histone pseudogene 16 Homo sapiens 267-270 16267097-2 2006 Competitive HDAC inhibitors disrupt the cell cycle and/or induce apoptosis via de-repression of genes such as P21 and BAX, and cancer cells appear to be more sensitive than non-transformed cells to trichostatin A and related HDAC inhibitory compounds. trichostatin A 198-212 H3 histone pseudogene 16 Homo sapiens 110-113 17849419-4 2008 RNAi-induced reduction of HDAC3 in SW480 cells increased their constitutive, butyrate-, TSA-, and TNF-alpha-induced expression of p21, but did not cause all the gene expression changes induced upon general histone deacetylase (HDAC) inhibition. trichostatin A 88-91 H3 histone pseudogene 16 Homo sapiens 130-133 17230511-9 2007 p21 induction is closely associated with FK228 or TSA but not 5-Aza, which is mediated via p53-independent pathway. trichostatin A 50-53 H3 histone pseudogene 16 Homo sapiens 0-3 16857700-3 2006 TSA caused a dose-dependent increase of G1-arrested cells at 24 h that correlated with increasing levels of p21 and apoptosis. trichostatin A 0-3 H3 histone pseudogene 16 Homo sapiens 108-111 16513842-6 2006 In addition, we found that doxorubicin inhibited AR expression, and p21 protein completely disappeared after simultaneous treatment with trichostatin A and doxorubicin. trichostatin A 137-151 H3 histone pseudogene 16 Homo sapiens 68-71 16513842-11 2006 The synergistic effect of simultaneous treatment with trichostatin A and doxorubicin is mediated via inhibition of AR expression, induction of protease activity, increased expression of p53, and proteolysis of p21. trichostatin A 54-68 H3 histone pseudogene 16 Homo sapiens 210-213 15746940-4 2005 TSA stabilizes the acetylation of p53 at Lys382, elevating p21 levels and inducing cell cycle arrest, but does not induce Bax translocation or apoptosis. trichostatin A 0-3 H3 histone pseudogene 16 Homo sapiens 59-62 15477762-6 2004 Whereas inhibition of HDACs by valproic acid or trichostatin A increases p21 expression, selective interference with HDAC2 by siRNA transfection or reconstitution of wildtype APC does not affect p21 expression. trichostatin A 48-62 H3 histone pseudogene 16 Homo sapiens 73-76 15632825-3 2005 This study aimed to evaluate the effect of calphostin C (a protein kinase C inhibitor) on trichostatin A (a histone deacetylase inhibitor)-mediated upregulation of nuclear factor kappaB and p21 promotor transcriptional activity, as well as induction of apoptosis in lung and esophageal cancer cells. trichostatin A 90-104 H3 histone pseudogene 16 Homo sapiens 190-193 15632825-9 2005 RESULTS: Exposure of lung or esophageal cancer cells to trichostatin A resulted in a dose- and cell-dependent 2-fold to greater than 20-fold increase of nuclear factor kappaB and p21 transcriptional activity. trichostatin A 56-70 H3 histone pseudogene 16 Homo sapiens 179-182 15632825-10 2005 Treatment with trichostatin A and calphostin C led to a 50% to 90% decrease of trichostatin A- mediated upregulation of nuclear factor kappaB and p21 activation. trichostatin A 15-29 H3 histone pseudogene 16 Homo sapiens 146-149 15632825-10 2005 Treatment with trichostatin A and calphostin C led to a 50% to 90% decrease of trichostatin A- mediated upregulation of nuclear factor kappaB and p21 activation. trichostatin A 79-93 H3 histone pseudogene 16 Homo sapiens 146-149 15632825-11 2005 Inhibition of nuclear factor kappaB activity resulted in significant reduction (30% to >99%) of trichostatin A- mediated activation of not only nuclear factor kappaB transcription but also p21 promotor activity. trichostatin A 99-113 H3 histone pseudogene 16 Homo sapiens 192-195 15632825-13 2005 CONCLUSION: Inhibition of protein kinase C abrogates trichostatin A-mediated upregulation of nuclear factor kappaB transcriptional activity and p21 expression that is associated with profound induction of apoptosis in lung or esophageal cancer cells. trichostatin A 53-67 H3 histone pseudogene 16 Homo sapiens 144-147 12481415-2 2002 Here we show that the HDIs sodium butyrate (Bu), trichostatin A (TSA) and depsipeptide (FR901228) all induced p21, but only TSA and FR901228 caused mitotic arrest (in addition to arrest in G1 and G2). trichostatin A 49-63 H3 histone pseudogene 16 Homo sapiens 110-113 15015635-7 2003 These results indicate that the expression of HDAC1 is regulated by hypoxia and the effect of TSA is closely related to the expression of P21 under hypoxia condition. trichostatin A 94-97 H3 histone pseudogene 16 Homo sapiens 138-141 12406558-5 2002 Cyclohexamide and TSA super-induced the expression of GADD45alpha and beta, but not p21(cip/waf). trichostatin A 18-21 H3 histone pseudogene 16 Homo sapiens 84-87 14526425-9 2003 Both sodium butyrate and trichostatin A could stimulate p21 expression of K562 cells at mRNA and protein levels. trichostatin A 25-39 H3 histone pseudogene 16 Homo sapiens 56-59 14526425-10 2003 It may be concluded that sodium butyrate and trichostatin A could promote the proliferation/differentiation of the K562 cells, which might be contributed to the induced expression of cyclin D3 and p21 proteins. trichostatin A 45-59 H3 histone pseudogene 16 Homo sapiens 197-200 12508652-13 2002 TSA acts as an anti-tumor agent could be through co-operation between p21 and p27 in growth inhibition, irrespective of endogenous p53 status. trichostatin A 0-3 H3 histone pseudogene 16 Homo sapiens 70-73 12481415-2 2002 Here we show that the HDIs sodium butyrate (Bu), trichostatin A (TSA) and depsipeptide (FR901228) all induced p21, but only TSA and FR901228 caused mitotic arrest (in addition to arrest in G1 and G2). trichostatin A 65-68 H3 histone pseudogene 16 Homo sapiens 110-113 12067978-4 2002 Induction of the Sp1-regulated p21 gene by Trichostatin A (TSA) was blocked by ET-743 at concentrations that had minimal effect on uninduced (constitutive) expression. trichostatin A 43-57 H3 histone pseudogene 16 Homo sapiens 31-34 12067978-4 2002 Induction of the Sp1-regulated p21 gene by Trichostatin A (TSA) was blocked by ET-743 at concentrations that had minimal effect on uninduced (constitutive) expression. trichostatin A 59-62 H3 histone pseudogene 16 Homo sapiens 31-34 10716680-0 2000 Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. trichostatin A 13-27 H3 histone pseudogene 16 Homo sapiens 138-141 10716680-12 2000 Butyrate and trichostatin A stimulated p21 expression both at the mRNA and protein levels, whereas their effects on the expression of cyclin dependent kinases were slightly different. trichostatin A 13-27 H3 histone pseudogene 16 Homo sapiens 39-42