PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30958996-0 2019 Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells. trichostatin A 45-59 tumor protein p53 Homo sapiens 112-115 30655814-8 2019 Furthermore, cell viability and apoptosis were revealed to depend on p53 during TSA treatment. trichostatin A 80-83 tumor protein p53 Homo sapiens 69-72 30318011-10 2019 CONCLUSION: The combination treatment of p53-null HL-60 cells with DNA-damaging agent CLB and HDACIs NaBu and TSA triggered additive to synergistic effects on apoptosis and upregulated BCL6 and p21 expression. trichostatin A 110-113 tumor protein p53 Homo sapiens 41-44 30655814-0 2019 Trichostatin A induces p53-dependent endoplasmic reticulum stress in human colon cancer cells. trichostatin A 0-14 tumor protein p53 Homo sapiens 23-26 30655814-10 2019 In conclusion, the current study revealed that TSA may induce ER stress via a p53-dependent mechanism in colon cancer cells. trichostatin A 47-50 tumor protein p53 Homo sapiens 78-81 29233643-0 2018 Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. trichostatin A 0-14 tumor protein p53 Homo sapiens 56-59 29735783-8 2018 CONCLUSION: We were able to demonstrate Wnt/ beta-catenin pathway modulation through E-cadherin up-regulation induced by 5aza-dC and TSA treatments, under an activation-pathway background, like CTNNB1 and TP53 mutations. trichostatin A 133-136 tumor protein p53 Homo sapiens 205-209 28884479-6 2018 Treatment with trichostatin A (TSA), a HDAC1 inhibitor, disrupted the interaction of p53-HDAC1-mSin3a complex with the nucleotides -365~-345 region, and enhanced the Aurora-A promoter activity and gene expression. trichostatin A 15-29 tumor protein p53 Homo sapiens 85-88 28884479-6 2018 Treatment with trichostatin A (TSA), a HDAC1 inhibitor, disrupted the interaction of p53-HDAC1-mSin3a complex with the nucleotides -365~-345 region, and enhanced the Aurora-A promoter activity and gene expression. trichostatin A 31-34 tumor protein p53 Homo sapiens 85-88 27716272-12 2016 Furthermore, siRNA assays were performed to analyse the role of p21 and p53 on TSA-mediated anti-lymphangiogenic effects. trichostatin A 79-82 tumor protein p53 Homo sapiens 72-75 27934110-6 2016 Next we evaluated the performance of the biosensor in HepG2 cells by treatment with ginkgolic acid, a drug that reduces p53 sumoylation, as well as trichostatin A, a potential inducer of p53 sumoylation by enhancement of its nuclear export. trichostatin A 148-162 tumor protein p53 Homo sapiens 187-190 28160167-6 2017 As underlying molecular events, we found that ERK1/2 was de-phosphorylated and that the c-Myc and mutant p53 protein levels were reduced after VPA and, to a lesser extent, after TSA treatment. trichostatin A 178-181 tumor protein p53 Homo sapiens 105-108 27877082-0 2016 Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. trichostatin A 30-44 tumor protein p53 Homo sapiens 98-101 27877082-6 2016 TSA significantly inhibited the growth of MG63 cells and promoted apoptosis in a dose-dependent manner through p53 signaling pathway activation. trichostatin A 0-3 tumor protein p53 Homo sapiens 111-114 25515622-8 2015 Investigation of Forkhead box O1 (FOXO1), superoxide dismutase 2 (SOD2), and p53 levels to determine intracellular signaling by TSA in oxidative stress-induced MSCs demonstrated that expression of phosphorylated-FOXO1 and phosphorylated-SOD2 decreased in H2 O2 -treated MSCs while levels of p53 increased. trichostatin A 128-131 tumor protein p53 Homo sapiens 291-294 26768552-0 2016 The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. trichostatin A 58-72 tumor protein p53 Homo sapiens 109-112 26768552-10 2016 The inhibitor of acetyltransferase, anacardic acid, diminished the enhancing effect of genistein on all TSA-induced histone/p53 acetylation and apoptosis. trichostatin A 104-107 tumor protein p53 Homo sapiens 124-127 26768552-13 2016 Taken together, these results suggest that the enhancing effects of genistein on TSA-induced apoptosis in lung cancer cells were p53-dependent and were associated with histone/non-histone protein acetylation. trichostatin A 81-84 tumor protein p53 Homo sapiens 129-132 25409339-4 2016 Simultaneous treatment of donor cells with TSA (50nM) and 5azadC (7.5nM) resulted in higher in vitro development to the blastocyst stage, reduction of the apoptotic index and the global level of H3K27 me3 and altered expression levels of HDAC1, P53, CASPASE3, CASPASE9 and DNMT3a in cloned blastocysts. trichostatin A 43-46 tumor protein p53 Homo sapiens 245-248 23745024-3 2013 Real time polymerase chain reaction and Western blotting were used to observe expression changes in p21, p53, Bax, Bcl-2, CDK2, and CyclinD1 in gastric cancer cells exposed to TSA. trichostatin A 176-179 tumor protein p53 Homo sapiens 105-108 25036040-10 2014 Trichostatin A and MS-275 (both HDAC inhibitors) inhibited the downstream pathway of HDAC1 and caused cell growth arrest via activation of p53 and p21; the effects of digoxigenin were totally opposite. trichostatin A 0-14 tumor protein p53 Homo sapiens 139-142 24676336-12 2014 For the TSA+DAC group, higher levels of p53, p21, cyclin B1 and Chk1 were detected, concomitant with lower levels of CDK1, when compared to the control group. trichostatin A 8-11 tumor protein p53 Homo sapiens 40-43 23745024-7 2013 p21, p53 and Bax gene expression levels in AGS cells were increased with TSA treatment duration; Bcl-2, CDK2, and CyclinD1 gene expression levels were decreased with TSA treatment duration. trichostatin A 73-76 tumor protein p53 Homo sapiens 5-8 23359343-9 2012 CONCLUSION: Both epigenetic reagents (5-Aza-Cdr/TSA) and Ad-p53 can suppress cell proliferation on Hep-2 in vivo and in vitro and there may be some antagonistic mechanism between Ad-p53 and epigenetic reagents (5-Aza-Cdr/ TSA). trichostatin A 48-51 tumor protein p53 Homo sapiens 182-185 23758695-10 2013 Our data also suggested that inhibition of pAkt and activation of p53 pathway are the main molecular events involved in inhibitory effects of TSA. trichostatin A 142-145 tumor protein p53 Homo sapiens 66-69 22290509-11 2013 We conclude that p53 independent apoptosis induced by combining curcumin and TSA involves JNK activation. trichostatin A 77-80 tumor protein p53 Homo sapiens 17-20 23342112-0 2013 Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. trichostatin A 45-59 tumor protein p53 Homo sapiens 84-87 23342112-2 2013 We first showed that quercetin (5 microM) significantly increased the growth arrest and apoptosis in A549 cells (expressing wild-type p53) induced by 25 ng/mL of (82.5 nM) TSA at 48 h by about 25% and 101%, respectively. trichostatin A 172-175 tumor protein p53 Homo sapiens 134-137 23342112-4 2013 In addition, quercetin significantly increased TSA-induced p53 expression in A549 cells. trichostatin A 47-50 tumor protein p53 Homo sapiens 59-62 23342112-11 2013 These data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing TSA-induced apoptosis in A549 cells. trichostatin A 111-114 tumor protein p53 Homo sapiens 57-60 23474493-5 2013 CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. trichostatin A 93-96 tumor protein p53 Homo sapiens 43-46 23359343-9 2012 CONCLUSION: Both epigenetic reagents (5-Aza-Cdr/TSA) and Ad-p53 can suppress cell proliferation on Hep-2 in vivo and in vitro and there may be some antagonistic mechanism between Ad-p53 and epigenetic reagents (5-Aza-Cdr/ TSA). trichostatin A 222-225 tumor protein p53 Homo sapiens 60-63 23359343-9 2012 CONCLUSION: Both epigenetic reagents (5-Aza-Cdr/TSA) and Ad-p53 can suppress cell proliferation on Hep-2 in vivo and in vitro and there may be some antagonistic mechanism between Ad-p53 and epigenetic reagents (5-Aza-Cdr/ TSA). trichostatin A 222-225 tumor protein p53 Homo sapiens 182-185 22552631-0 2012 The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. trichostatin A 34-48 tumor protein p53 Homo sapiens 132-135 22552631-4 2012 Here, we report that, Trichostatin A (TSA), a pan-HDAC inhibitor, could induce G2/M cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (HT116 cells) and mutant p53 (HT29 cells), although HCT116 cells had more apoptotic cells than HT29 cells. trichostatin A 22-36 tumor protein p53 Homo sapiens 192-195 22552631-4 2012 Here, we report that, Trichostatin A (TSA), a pan-HDAC inhibitor, could induce G2/M cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (HT116 cells) and mutant p53 (HT29 cells), although HCT116 cells had more apoptotic cells than HT29 cells. trichostatin A 22-36 tumor protein p53 Homo sapiens 221-224 22552631-4 2012 Here, we report that, Trichostatin A (TSA), a pan-HDAC inhibitor, could induce G2/M cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (HT116 cells) and mutant p53 (HT29 cells), although HCT116 cells had more apoptotic cells than HT29 cells. trichostatin A 38-41 tumor protein p53 Homo sapiens 192-195 22552631-4 2012 Here, we report that, Trichostatin A (TSA), a pan-HDAC inhibitor, could induce G2/M cell cycle arrest and apoptosis in both colorectal cancer cell lines with wild-type p53 (HT116 cells) and mutant p53 (HT29 cells), although HCT116 cells had more apoptotic cells than HT29 cells. trichostatin A 38-41 tumor protein p53 Homo sapiens 221-224 22552631-8 2012 These data suggest that TSA induces G2/M cell cycle arrest and Bax-dependent apoptosis in colorectal cancer cells (HCT116 cells and HT29 cells) by both p53-dependent and -independent mechanisms. trichostatin A 36-39 tumor protein p53 Homo sapiens 176-179 22552631-9 2012 However, cells with normal p53 function are more sensitive to TSA-induced apoptosis. trichostatin A 74-77 tumor protein p53 Homo sapiens 27-30 21468663-9 2011 Moreover, the pretreatment with trichostatin A (TSA, a histone deacetylase inhibitor) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting ERK phosphorylation, reactivating caspases and PARP, and inducing translocation of p53 and Bid to cytoplasm. trichostatin A 32-46 tumor protein p53 Homo sapiens 268-271 21468663-9 2011 Moreover, the pretreatment with trichostatin A (TSA, a histone deacetylase inhibitor) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting ERK phosphorylation, reactivating caspases and PARP, and inducing translocation of p53 and Bid to cytoplasm. trichostatin A 48-51 tumor protein p53 Homo sapiens 268-271 21468663-9 2011 Moreover, the pretreatment with trichostatin A (TSA, a histone deacetylase inhibitor) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting ERK phosphorylation, reactivating caspases and PARP, and inducing translocation of p53 and Bid to cytoplasm. trichostatin A 89-92 tumor protein p53 Homo sapiens 268-271 21519790-0 2011 Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. trichostatin A 50-64 tumor protein p53 Homo sapiens 115-118 21519790-11 2011 We found that VPA and TSA induce apoptosis, upregulate p21/Waf1/CIP1, repress TMPRSS2-ERG expression and affect acetylation status of p53 in VCaP cells. trichostatin A 22-25 tumor protein p53 Homo sapiens 134-137 22493143-0 2012 Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. trichostatin A 29-32 tumor protein p53 Homo sapiens 22-25 22493143-5 2012 An activation of p53 (TP53) transcriptional activity in Dox- or Dox+TSA-treated cells was revealed by the increased expression levels of p53 mRNA/protein as well as p53-driven luciferase activities. trichostatin A 68-71 tumor protein p53 Homo sapiens 17-20 22493143-5 2012 An activation of p53 (TP53) transcriptional activity in Dox- or Dox+TSA-treated cells was revealed by the increased expression levels of p53 mRNA/protein as well as p53-driven luciferase activities. trichostatin A 68-71 tumor protein p53 Homo sapiens 22-26 22493143-5 2012 An activation of p53 (TP53) transcriptional activity in Dox- or Dox+TSA-treated cells was revealed by the increased expression levels of p53 mRNA/protein as well as p53-driven luciferase activities. trichostatin A 68-71 tumor protein p53 Homo sapiens 137-140 22493143-5 2012 An activation of p53 (TP53) transcriptional activity in Dox- or Dox+TSA-treated cells was revealed by the increased expression levels of p53 mRNA/protein as well as p53-driven luciferase activities. trichostatin A 68-71 tumor protein p53 Homo sapiens 137-140 22270849-0 2012 P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. trichostatin A 61-75 tumor protein p53 Homo sapiens 0-3 22270849-0 2012 P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. trichostatin A 77-80 tumor protein p53 Homo sapiens 0-3 22270849-8 2012 Characterizing the chromatin modulation around the p21(WAF1) promoter after TSA treatment using chromatin immunoprecipitation, we found (1) a release of HDAC1, (2) an increase of acetylated H4 binding, and (3) enhanced recruitment of p53. trichostatin A 76-79 tumor protein p53 Homo sapiens 234-237 22270849-12 2012 Furthermore, TSA-treated p53-mutant cell line U138 failed to show an induction in p21(WAF1), showed a deficient G2/M checkpoint, and underwent mitotic catastrophe. trichostatin A 13-16 tumor protein p53 Homo sapiens 25-28 22214764-8 2012 Functionally, the cytoplasmic accumulation of ZBP-89 by p53(G245D) significantly abrogated the induction of p21 caused by sodium butyrate (NaB) treatment and protected cells from TSA-induced death. trichostatin A 179-182 tumor protein p53 Homo sapiens 56-59 21376104-0 2011 p53 in trichostatin A induced C6 glioma cell death. trichostatin A 7-21 tumor protein p53 Homo sapiens 0-3 21376104-5 2011 RESULTS: TSA activated p38 mitogen-activated protein kinase (p38MAPK), leading to p53 phosphorylation and activation. trichostatin A 9-12 tumor protein p53 Homo sapiens 82-85 21376104-10 2011 CONCLUSIONS: TSA may cause C6 cell apoptosis through activating p38MAPK-p53 cascade resulting in Bax expression and survivin suppression. trichostatin A 13-16 tumor protein p53 Homo sapiens 72-75 21376104-12 2011 GENERAL SIGNIFICANCE: TSA-induced p53 activation may occur through p53 modification by phosphorylation or by acetylation via IKK inactivation. trichostatin A 22-25 tumor protein p53 Homo sapiens 34-37 21376104-12 2011 GENERAL SIGNIFICANCE: TSA-induced p53 activation may occur through p53 modification by phosphorylation or by acetylation via IKK inactivation. trichostatin A 22-25 tumor protein p53 Homo sapiens 67-70 20640432-8 2010 In addition, percentage of cells expressing p53 and p504S expression was higher in TSA than those of HP and SSA/SSP. trichostatin A 83-86 tumor protein p53 Homo sapiens 44-47 21346816-6 2011 Culture of PBMC with TSA resulted in increased expression of p53 in HC but not in MS patients. trichostatin A 21-24 tumor protein p53 Homo sapiens 61-64 20931131-9 2011 The effect of this compound was dramatically increased when used in combination with chemotherapeutic drug and/or the HDAC inhibitor Trichostatin A, confirming a proposed synergistic mechanism of p53 deacetylation by SIRT1 and Type I/II HDACs. trichostatin A 133-147 tumor protein p53 Homo sapiens 196-199 20868669-4 2010 Trichostatin A induced nuclear damage, decreased Bid and Bcl-2 protein levels, increased in Bax levels, induced cytochrome c release, activated caspase-8, -9 and -3, and increased tumor suppressor p53 levels. trichostatin A 0-14 tumor protein p53 Homo sapiens 197-200 20811720-5 2010 In this study, we investigated the effect of trichostatin A or TSA (an HDAC inhibitor), and epoxomycin (a proteasome inhibitor) on MYCN and p53 expression in MYCN-amplified neuroblastoma cells. trichostatin A 63-66 tumor protein p53 Homo sapiens 140-143 20811720-9 2010 Furthermore, Epoxomycin as a single agent and its combination with TSA enhance p53 expression in the MYCN-amplified neuroblastoma cell lines. trichostatin A 67-70 tumor protein p53 Homo sapiens 79-82 20811720-5 2010 In this study, we investigated the effect of trichostatin A or TSA (an HDAC inhibitor), and epoxomycin (a proteasome inhibitor) on MYCN and p53 expression in MYCN-amplified neuroblastoma cells. trichostatin A 45-59 tumor protein p53 Homo sapiens 140-143 19513516-0 2009 Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. trichostatin A 0-14 tumor protein p53 Homo sapiens 40-43 19889954-8 2010 Mechanistically, SAHA inhibited and TSA delayed p53 phosphorylation, acetylation, and activation during cisplatin incubation. trichostatin A 36-39 tumor protein p53 Homo sapiens 48-51 20505264-6 2010 We also observed that TSA-mediated radiosensitization was clearly influenced by p53 and ATM status of cells tested. trichostatin A 22-25 tumor protein p53 Homo sapiens 80-83 20962589-6 2010 Downregulation of PLK1 expression by p53 is relieved by the histone deacetylase inhibitor, trichostatin A, and involves recruitment of histone deacetylase to the vicinity of p53RE2, further supporting a transcriptional repression mechanism. trichostatin A 91-105 tumor protein p53 Homo sapiens 37-40 20375332-9 2010 TSA induced caspase-mediated apoptotic pathways; caspase induction was accompanied by a decrease in endogenous DeltaNp63alpha and p53. trichostatin A 0-3 tumor protein p53 Homo sapiens 130-133 20681406-13 2010 The data suggest that ING1 contributes to TSA-induced apoptosis in GBM cells with deficient p53 and p14(ARF)/p16(INK4a) functions, possibly by regulating FADD/caspase 3 signaling. trichostatin A 42-45 tumor protein p53 Homo sapiens 92-95 18097557-2 2008 Trichostatin A (TSA), ITF2357 and suberoylanilide hydroxamic acid (SAHA), which were very effective agents, caused apoptotic effects after a lag phase of 12-16 h. In order to elucidate the mechanism of HDACIs action in HepG2 cells we have studied the effects of TSA, ITF2357 and SAHA on acetylation of p53 and histones H2A, H2B, H3 and H4. trichostatin A 0-14 tumor protein p53 Homo sapiens 302-305 18949380-5 2008 In addition, TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells. trichostatin A 13-16 tumor protein p53 Homo sapiens 122-125 18708766-4 2008 DP, TSA and SAHA inhibited Aurora A, Aurora B and survivin expression with kinetics that were remarkably similar within individual cell lines, and appeared to coincide with p53 expression status. trichostatin A 4-7 tumor protein p53 Homo sapiens 173-176 18645003-1 2008 Previous studies comparing the effects of two histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and CG-1521, have shown that these compounds selectively inhibit HDAC and induce differentially acetylated p53 isoforms and assembly of mutually exclusive transcriptional complexes on the p21 promoter. trichostatin A 85-99 tumor protein p53 Homo sapiens 213-216 18645003-1 2008 Previous studies comparing the effects of two histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and CG-1521, have shown that these compounds selectively inhibit HDAC and induce differentially acetylated p53 isoforms and assembly of mutually exclusive transcriptional complexes on the p21 promoter. trichostatin A 101-104 tumor protein p53 Homo sapiens 213-216 18566213-7 2008 Pretreatment of resistant A2780 CIS cells with the histone deacetylase inhibitor trichostatin A overcomes apoptosis resistance to CDDP by restoring both p73 and Bax but not p53 expression. trichostatin A 81-95 tumor protein p53 Homo sapiens 173-176 18483381-4 2008 RESULTS: In this report, we show that the HDIs trichostatin A, sodium butyrate, and low nanomolar doses of LAQ824 combined with the glycolysis inhibitor 2-deoxy-d-glucose induce strong apoptosis in cancer cell lines of brain, breast, and cervix in a p53-independent manner. trichostatin A 47-61 tumor protein p53 Homo sapiens 250-253 18644983-7 2008 In addition, our data suggest that trichostatin A-induced p21(WAF1/Cip1) protein expression might be mediated through a p53-independent and HDAC deacetylase-independent pathway. trichostatin A 35-49 tumor protein p53 Homo sapiens 120-123 18419600-0 2008 Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. trichostatin A 0-14 tumor protein p53 Homo sapiens 22-25 18097557-2 2008 Trichostatin A (TSA), ITF2357 and suberoylanilide hydroxamic acid (SAHA), which were very effective agents, caused apoptotic effects after a lag phase of 12-16 h. In order to elucidate the mechanism of HDACIs action in HepG2 cells we have studied the effects of TSA, ITF2357 and SAHA on acetylation of p53 and histones H2A, H2B, H3 and H4. trichostatin A 16-19 tumor protein p53 Homo sapiens 302-305 16426753-8 2006 Trichostatin (TSA), a p53 inhibitor, can block the effects of tolbutamide, lending further support for a role of p53 in mediating this process. trichostatin A 0-12 tumor protein p53 Homo sapiens 22-25 17230511-9 2007 p21 induction is closely associated with FK228 or TSA but not 5-Aza, which is mediated via p53-independent pathway. trichostatin A 50-53 tumor protein p53 Homo sapiens 91-94 17172643-1 2007 Trichostatin A (TSA), a specific inhibitor of histone deacetylases (HDACs), induces acetylation of various non-histone proteins such as p53 and alpha-tubulin. trichostatin A 0-14 tumor protein p53 Homo sapiens 136-139 17172643-1 2007 Trichostatin A (TSA), a specific inhibitor of histone deacetylases (HDACs), induces acetylation of various non-histone proteins such as p53 and alpha-tubulin. trichostatin A 16-19 tumor protein p53 Homo sapiens 136-139 17344317-7 2007 However, treatment with the histone deacetylase inhibitor trichostatin-A resulted in relief of mutant p53-mediated suppression, suggesting that mutant p53 may induce hypo-acetylation of target gene promoters leading to the suppressive effects. trichostatin A 58-72 tumor protein p53 Homo sapiens 102-105 17344317-7 2007 However, treatment with the histone deacetylase inhibitor trichostatin-A resulted in relief of mutant p53-mediated suppression, suggesting that mutant p53 may induce hypo-acetylation of target gene promoters leading to the suppressive effects. trichostatin A 58-72 tumor protein p53 Homo sapiens 151-154 16865256-6 2006 TSA increases the expression of p21, p53, DAPK-1 and the DAPK-2 gene in both OCUM-8 and MKN-74 cells. trichostatin A 0-3 tumor protein p53 Homo sapiens 37-40 16865256-8 2006 The up-regulation of p53, p21, DAPK-1 and DAPK-2 might be associated with the synergistic effect of TSA. trichostatin A 100-103 tumor protein p53 Homo sapiens 21-24 16847267-7 2006 In addition, combined trichostatin A/ET treatment in melanoma cells expressing high MAGE-A levels reestablishes p53 response and reverts the chemoresistance. trichostatin A 22-36 tumor protein p53 Homo sapiens 112-115 16474844-9 2006 Trichostatin A abolished the inhibitory effect of wt p53, suggesting the involvement of histone deacetylation in negative regulation of the heparanase promoter. trichostatin A 0-14 tumor protein p53 Homo sapiens 53-56 17669439-6 2007 Elevated expressions of p53 and p21 with a decrease in cyclin-D level supported the observation on cell cycle arrest following TSA treatment. trichostatin A 127-130 tumor protein p53 Homo sapiens 24-27 21162257-4 2007 In contrast, tolbutamide (100 micromol/L), the K(ATP) channels antagonist, significantly rose p53 expression and the hypoxia-induced apoptosis, which could be reversed by p53 inhibitor TSA. trichostatin A 185-188 tumor protein p53 Homo sapiens 94-97 21162257-4 2007 In contrast, tolbutamide (100 micromol/L), the K(ATP) channels antagonist, significantly rose p53 expression and the hypoxia-induced apoptosis, which could be reversed by p53 inhibitor TSA. trichostatin A 185-188 tumor protein p53 Homo sapiens 171-174 17121856-3 2007 This study investigates the action of two HDAC inhibitors, CG-1521 and trichostatin A, which stabilize Ac-Lys-373 p53 and Ac-Lys-382 p53, respectively, in LNCaP prostate cancer cells. trichostatin A 71-85 tumor protein p53 Homo sapiens 114-117 17121856-3 2007 This study investigates the action of two HDAC inhibitors, CG-1521 and trichostatin A, which stabilize Ac-Lys-373 p53 and Ac-Lys-382 p53, respectively, in LNCaP prostate cancer cells. trichostatin A 71-85 tumor protein p53 Homo sapiens 133-136 16426753-8 2006 Trichostatin (TSA), a p53 inhibitor, can block the effects of tolbutamide, lending further support for a role of p53 in mediating this process. trichostatin A 0-12 tumor protein p53 Homo sapiens 113-116 16426753-8 2006 Trichostatin (TSA), a p53 inhibitor, can block the effects of tolbutamide, lending further support for a role of p53 in mediating this process. trichostatin A 14-17 tumor protein p53 Homo sapiens 22-25 16426753-8 2006 Trichostatin (TSA), a p53 inhibitor, can block the effects of tolbutamide, lending further support for a role of p53 in mediating this process. trichostatin A 14-17 tumor protein p53 Homo sapiens 113-116 16513842-11 2006 The synergistic effect of simultaneous treatment with trichostatin A and doxorubicin is mediated via inhibition of AR expression, induction of protease activity, increased expression of p53, and proteolysis of p21. trichostatin A 54-68 tumor protein p53 Homo sapiens 186-189 16467109-6 2006 Interestingly, radiosensitization by TSA in cell lines expressing p53 was more pronounced than in isogenic lines lacking p53. trichostatin A 37-40 tumor protein p53 Homo sapiens 66-69 16467109-7 2006 Radiosensitization of cells expressing p53 by TSA was reduced by pifithrin-alpha, a small-molecule inhibitor of p53. trichostatin A 46-49 tumor protein p53 Homo sapiens 39-42 16467109-7 2006 Radiosensitization of cells expressing p53 by TSA was reduced by pifithrin-alpha, a small-molecule inhibitor of p53. trichostatin A 46-49 tumor protein p53 Homo sapiens 112-115 16354677-6 2006 EX-527 and TSA acted synergistically to increase acetyl-p53 levels, confirming that p53 acetylation is regulated by both SIRT1 and HDACs. trichostatin A 11-14 tumor protein p53 Homo sapiens 84-87 16177181-5 2005 TSA-induced toxicity stimulates apoptosis and cell cycle checkpoint responses independent of p53, but does not increase phosphorylated histone H2AX (-H2AX) as compared with a clastogenic agent, camptothecin, indicating that the quantity of DSBs is not the primary cause of TSA-induced cell death. trichostatin A 0-3 tumor protein p53 Homo sapiens 93-96 16354677-5 2006 Acetyl-p53 was also increased by the histone deacetylase (HDAC) class I/II inhibitor trichostatin A (TSA). trichostatin A 85-99 tumor protein p53 Homo sapiens 7-10 16354677-5 2006 Acetyl-p53 was also increased by the histone deacetylase (HDAC) class I/II inhibitor trichostatin A (TSA). trichostatin A 101-104 tumor protein p53 Homo sapiens 7-10 16354677-6 2006 EX-527 and TSA acted synergistically to increase acetyl-p53 levels, confirming that p53 acetylation is regulated by both SIRT1 and HDACs. trichostatin A 11-14 tumor protein p53 Homo sapiens 56-59 15827334-9 2005 Western immunoblot analysis indicated trichostatin A triggers apoptosis in resistant ovarian cancer cells via p53-independent activation of the intrinsic "mitochondrial" pathway, commensurate with induction of the Bcl-2-related protein Bad. trichostatin A 38-52 tumor protein p53 Homo sapiens 110-113 15892716-4 2005 We have studied the cellular effects of trichostatin A (TSA), a HDAC inhibitor, in a panel of melanoma cell lines and its mechanism of action in relation to p53. trichostatin A 40-54 tumor protein p53 Homo sapiens 157-160 15892716-5 2005 TSA stabilized wild-type p53, but p53 protein accumulation was overridden by simultaneous downregulation of p53 mRNA leading to a decrease in p53 protein. trichostatin A 0-3 tumor protein p53 Homo sapiens 25-28 15746940-4 2005 TSA stabilizes the acetylation of p53 at Lys382, elevating p21 levels and inducing cell cycle arrest, but does not induce Bax translocation or apoptosis. trichostatin A 0-3 tumor protein p53 Homo sapiens 34-37 16103091-2 2005 We show that histone deacetylase inhibitors such as FR901228 and trichostatin A completely depleted mutant p53 in cancer cell lines. trichostatin A 65-79 tumor protein p53 Homo sapiens 107-110 15892716-7 2005 Inhibiting p53 function by a dominant negative p53 (p53(175His)) confirmed that the HDAC inhibitor induced apoptosis was independent of wild-type p53, even though TSA slightly activated p53 in a reporter assay. trichostatin A 163-166 tumor protein p53 Homo sapiens 11-14 15878336-9 2005 Moreover, TSA sensitization to UV-induced apoptosis is p53 dependent. trichostatin A 10-13 tumor protein p53 Homo sapiens 55-58 15179185-3 2004 TSA significantly induced protein expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in a dose-dependent manner in all cell lines including those not expressing p21(WAF1/CIP1) constitutively, whereas the levels of both wild-type and mutated p53 protein were reduced. trichostatin A 0-3 tumor protein p53 Homo sapiens 257-260 15674351-11 2005 While RA alone had no effect on p53-NRD activity, cotreatment with RA and the histone deacetylase inhibitor trichostatin-A (TSA) completely relieved p53-NRD-mediated repression. trichostatin A 108-122 tumor protein p53 Homo sapiens 149-152 15674351-11 2005 While RA alone had no effect on p53-NRD activity, cotreatment with RA and the histone deacetylase inhibitor trichostatin-A (TSA) completely relieved p53-NRD-mediated repression. trichostatin A 124-127 tumor protein p53 Homo sapiens 149-152 15967108-6 2005 Significantly, p53-mediated SAK repression was largely reversed in a dose-dependent manner by Trichostatin A, a potent histone deacetylase (HDAC) inhibitor, suggesting an involvement of HDAC transcription repressors in SAK repression by p53. trichostatin A 94-108 tumor protein p53 Homo sapiens 15-18 15967108-6 2005 Significantly, p53-mediated SAK repression was largely reversed in a dose-dependent manner by Trichostatin A, a potent histone deacetylase (HDAC) inhibitor, suggesting an involvement of HDAC transcription repressors in SAK repression by p53. trichostatin A 94-108 tumor protein p53 Homo sapiens 237-240 15674334-6 2005 The camptothecin or etoposide-dependent p53-mediated repression was attenuated by trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs). trichostatin A 82-96 tumor protein p53 Homo sapiens 40-43 15674334-6 2005 The camptothecin or etoposide-dependent p53-mediated repression was attenuated by trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs). trichostatin A 98-101 tumor protein p53 Homo sapiens 40-43 14612526-7 2003 Moreover, pretreatment with TSA also increased VP-16-induced apoptosis in a p53-dependent and -independent manner. trichostatin A 28-31 tumor protein p53 Homo sapiens 76-79 14695212-2 2003 We, in the present study, first confirmed that some substantial extent of apoptotic cell death was seen when p53-deficient cells (KATO-III) were transfected with wild-type p53 and treated with sodium butyrate (SB) or trichostatin A. trichostatin A 217-231 tumor protein p53 Homo sapiens 109-112 12876282-9 2003 Trichostatin A, a histone deacetylase inhibitor, relieved the p53 transrepression activity on MAD1. trichostatin A 0-14 tumor protein p53 Homo sapiens 62-65 14583461-8 2003 The most striking p53-related effects are at K9, which is underacetylated in p53-/- cells under normal conditions of growth but which shows a dramatic increase in acetylation after combined treatment with UV plus TSA. trichostatin A 213-216 tumor protein p53 Homo sapiens 18-21 14583461-8 2003 The most striking p53-related effects are at K9, which is underacetylated in p53-/- cells under normal conditions of growth but which shows a dramatic increase in acetylation after combined treatment with UV plus TSA. trichostatin A 213-216 tumor protein p53 Homo sapiens 77-80 21432092-8 2003 Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a downstream target gene of p53, in a p53-independent manner. trichostatin A 78-92 tumor protein p53 Homo sapiens 207-210 21432092-8 2003 Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a downstream target gene of p53, in a p53-independent manner. trichostatin A 78-92 tumor protein p53 Homo sapiens 217-220 21432092-8 2003 Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a downstream target gene of p53, in a p53-independent manner. trichostatin A 94-97 tumor protein p53 Homo sapiens 207-210 21432092-8 2003 Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a downstream target gene of p53, in a p53-independent manner. trichostatin A 94-97 tumor protein p53 Homo sapiens 217-220 14586402-4 2003 We show here that it is also induced by a typical HDAC inhibitor, trichostatin A (TSA), through its promoter, in a p53-independent manner. trichostatin A 66-80 tumor protein p53 Homo sapiens 115-118 14586402-4 2003 We show here that it is also induced by a typical HDAC inhibitor, trichostatin A (TSA), through its promoter, in a p53-independent manner. trichostatin A 82-85 tumor protein p53 Homo sapiens 115-118 14502645-2 2003 Accordingly, HDAC inhibitors such as trichostatin A (TSA) have potential utility in pancreatic cancer, as most of these tumors possess mutations in p53, which in fact is the main cause of chemoresistance to 5-fluorouracil. trichostatin A 37-51 tumor protein p53 Homo sapiens 148-151 14502645-2 2003 Accordingly, HDAC inhibitors such as trichostatin A (TSA) have potential utility in pancreatic cancer, as most of these tumors possess mutations in p53, which in fact is the main cause of chemoresistance to 5-fluorouracil. trichostatin A 53-56 tumor protein p53 Homo sapiens 148-151 14502645-6 2003 The expression of p21(WAF1/CIP1) normally induced at the transcriptional level by p53 was also strongly activated by TSA. trichostatin A 117-120 tumor protein p53 Homo sapiens 82-85 12716906-5 2003 Treating human umbilical vein endothelial cells with trichostatin A (TSA), an HDAC inhibitor, abolished the flow-induced p53 deacetylation at Lys-320 and Lys-373. trichostatin A 53-67 tumor protein p53 Homo sapiens 121-124 12954772-8 2003 Treatment with trichostatin A, which is an inhibitor of histone deacetylase, or PML over-expression relieved Daxx-mediated transcriptional repression of p53. trichostatin A 15-29 tumor protein p53 Homo sapiens 153-156 12716906-5 2003 Treating human umbilical vein endothelial cells with trichostatin A (TSA), an HDAC inhibitor, abolished the flow-induced p53 deacetylation at Lys-320 and Lys-373. trichostatin A 69-72 tumor protein p53 Homo sapiens 121-124 12716906-6 2003 To investigate the role of the HDAC-deacetylated p53 in the flow activation of p21Waf1, we found that TSA inhibited the activation at both the mRNA and protein levels. trichostatin A 102-105 tumor protein p53 Homo sapiens 49-52 12716906-7 2003 Deletion and mutation analyses of the p21Waf1 promoter revealed that flow activated p21Waf1 through p53 and TSA abrogated this p53-dependent activation. trichostatin A 108-111 tumor protein p53 Homo sapiens 127-130 12556448-9 2003 We also demonstrate that the susceptibility to TSA- and SAHA-induced cell death is regulated by p53. trichostatin A 47-50 tumor protein p53 Homo sapiens 96-99 12508652-4 2002 MATERIALS AND METHODS: A p53 mutant human glioma cell line T98G and a p53 wild type human neuroblastoma cell line SKNSH were exposed to TSA. trichostatin A 136-139 tumor protein p53 Homo sapiens 70-73 12556448-0 2003 Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). trichostatin A 101-115 tumor protein p53 Homo sapiens 27-30 12556448-0 2003 Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). trichostatin A 117-120 tumor protein p53 Homo sapiens 27-30 12508652-7 2002 Expression patterns of accumulation of highly acetylated histone H3, H4; p53 and cell cycle-associated p21waf, p27 which were induced by TSA were determined by using Western blot analysis. trichostatin A 137-140 tumor protein p53 Homo sapiens 73-76 12200149-1 2002 We determined the molecular mechanisms by which trichostatin A (TSA) induced insulin-like growth factor-binding protein 3 (IGFBP-3) gene expression in Hep3B cells, a p53-mutant human hepatocellular carcinoma (HCC) cell line. trichostatin A 48-62 tumor protein p53 Homo sapiens 166-169 12200149-1 2002 We determined the molecular mechanisms by which trichostatin A (TSA) induced insulin-like growth factor-binding protein 3 (IGFBP-3) gene expression in Hep3B cells, a p53-mutant human hepatocellular carcinoma (HCC) cell line. trichostatin A 64-67 tumor protein p53 Homo sapiens 166-169 11791186-5 2002 The inhibitory effect of wild type p53 was undetectable in the presence of trichostatin A, suggesting the involvement of histone deacetylation in negative regulation of PSA promoter activity. trichostatin A 75-89 tumor protein p53 Homo sapiens 35-38 11818510-6 2002 Competition for coactivator CREB binding protein could not entirely account for the repression but trichostatin A, an inhibitor of histone deacetylase activity, could reverse p53-mediated repression of HNF4alpha1. trichostatin A 99-113 tumor protein p53 Homo sapiens 175-178 11818510-7 2002 In contrast, p53-mediated repression of transcriptional activation of the same promoter by another transcriptional activator, CCAAT/enhancer-binding protein-alpha, could not be reversed by the addition of trichostatin A. trichostatin A 205-219 tumor protein p53 Homo sapiens 13-16 10667218-6 1999 This finding indicates that TSA activates the p21/WAF1/Cip1 promoter through the Sp1 sites in a p53-independent manner. trichostatin A 28-31 tumor protein p53 Homo sapiens 96-99 11283670-4 2001 A specific HDAC inhibitor, trichostatin A (TSA), upregulated p53 and von Hippel-Lindau expression and downregulated hypoxia-inducible factor-1alpha and vascular endothelial growth factor. trichostatin A 27-41 tumor protein p53 Homo sapiens 61-64 11283670-4 2001 A specific HDAC inhibitor, trichostatin A (TSA), upregulated p53 and von Hippel-Lindau expression and downregulated hypoxia-inducible factor-1alpha and vascular endothelial growth factor. trichostatin A 43-46 tumor protein p53 Homo sapiens 61-64 10521394-4 1999 We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin. trichostatin A 15-29 tumor protein p53 Homo sapiens 108-111 10521394-4 1999 We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin. trichostatin A 31-34 tumor protein p53 Homo sapiens 108-111 11313951-7 2001 Treatment of K562 cells with the histone deacetylase inhibitor, trichostatin A, resulted in an increase in bcl-2 promoter activity whether p53 was present or not. trichostatin A 64-78 tumor protein p53 Homo sapiens 139-142 11093826-4 2000 TSA enhanced the protein expression of p21(WAF1), CREB-binding protein, cyclinE, cyclin A, Bak and Bax, while it reduced the expression of E2F-1, E2F-4, HDAC1, p53 and hyperphosphorylated form of Rb. trichostatin A 0-3 tumor protein p53 Homo sapiens 160-163 9405248-7 1997 These findings indicate that TSA induces the WAF1/Cip1 promoter through the typical Sp1 sites, in a p53-independent fashion. trichostatin A 29-32 tumor protein p53 Homo sapiens 100-103 21380726-4 2011 Trichostatin A induced nuclear damage, decrease in Bid and Bcl-2 protein levels, increase in Bax levels, cytochrome c release, activation of caspases (8, 9, and 3) and increase in tumor suppressor p53 levels. trichostatin A 0-14 tumor protein p53 Homo sapiens 197-200