PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17202837-5 2006 Catalytic activation of caspase-9 and decreased expression of anti-apoptotic Bcl-2 and Bcl-XL proteins were observed in TSA-treated cells. trichostatin A 120-123 BCL2 like 1 Homo sapiens 87-93 18071312-4 2008 Co-treatment, but not single treatment, with VP16 and TSA induced apoptosis in a caspase-dependent manner accompanied by a crucial decrease in Bcl-xL expression allowing Bax activation and subsequent initiation of the apoptosis inducing factor (AIF)-dependent death pathway. trichostatin A 54-57 BCL2 like 1 Homo sapiens 143-149 16435155-6 2006 TSA treatment repressed the transcription and downregulated the expression of the antiapoptotic Bcl-2 proteins; Bcl-2 and Bcl-XL. trichostatin A 0-3 BCL2 like 1 Homo sapiens 122-128 16904634-4 2006 Combining TSA with PS-341 effectively inactivated NFkappaB signaling, downregulated the predominant endogenous anti-apoptotic factor Bcl-XL overexpression, and disrupted MAP kinase pathway. trichostatin A 10-13 BCL2 like 1 Homo sapiens 133-139 16167063-6 2006 In addition, trichostatin A reduced the expression of Bcl-X(L) and cFLIP resulting in increased sensitivity to recombinant TRAIL. trichostatin A 13-27 BCL2 like 1 Homo sapiens 54-62 16009488-4 2006 The expression levels of Mcl-1 and Bcl-XL but not those of Bcl-2, Bax, and Bak were suppressed by TSA or SK-7041 treatment. trichostatin A 98-101 BCL2 like 1 Homo sapiens 35-41 16009488-5 2006 SK-7041 or TSA induced apoptosis and G2-M cell cycle arrest by up-regulating p21 and down-regulating cyclin B1, Mcl-1, and Bcl-XL. trichostatin A 11-14 BCL2 like 1 Homo sapiens 123-129 11154071-4 2000 The obtained data suggest that TSA induces pro-apoptotic genes like ID1, ID2, ID3, and down-regulates anti-apoptotic genes like Hsp27 and Bcl-xL, thereby shifting the cellular equilibrium from life to death. trichostatin A 31-34 BCL2 like 1 Homo sapiens 138-144 15781649-8 2005 The knockdown of the predominant Bcl-XL overexpression significantly reduces the viability of pancreatic cancer cells to TNFalpha- and TRAIL-mediated apoptosis by sublethal-dose single and combined antitumor drugs, including geldanamycin, PS-341, Trichostatin A, and doxorubicine. trichostatin A 247-261 BCL2 like 1 Homo sapiens 33-39 10746741-0 2000 Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. trichostatin A 0-14 BCL2 like 1 Homo sapiens 53-59 30334455-6 2018 TSA treatment leads to decreased expression of CYCLIN D1, CDK4, CDK6 and BCL-XL, but increased P21 expression. trichostatin A 0-3 BCL2 like 1 Homo sapiens 73-79 25959059-3 2015 Here we show that TSA, a deacetylase inhibitor, reduced the ratio of Bcl-x splice variants Bcl-xL/xS in MDA-MB-231 breast cancer cells. trichostatin A 18-21 BCL2 like 1 Homo sapiens 69-74 25959059-3 2015 Here we show that TSA, a deacetylase inhibitor, reduced the ratio of Bcl-x splice variants Bcl-xL/xS in MDA-MB-231 breast cancer cells. trichostatin A 18-21 BCL2 like 1 Homo sapiens 91-97 22552631-6 2012 Additionally, TSA induces expression of the pro-apoptotic protein Bax and decreases the expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL in both cell lines. trichostatin A 26-29 BCL2 like 1 Homo sapiens 164-170 34903991-6 2021 The result indicated that zebularine and TSA changed the expression level of the Bax, Bak, Bim Bcl-2, Bcl-xL, Mcl-1, DR4, DR5, FAS, FAS-L, TRAIL, DNA methyltransferase 1, 3a, and 3b, histone deacetylase inhibitors 1, 2, and 3 by which induced cell apoptosis and inhibit cell growth in all three cell lines. trichostatin A 41-44 BCL2 like 1 Homo sapiens 102-108