PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20553909-6	2010	Our results show, for the first time, that TSA inhibits TGF-beta1-induced ERK activation and overrides pro-apoptotic signals like Smad3 and p38 in human RPTECs.	trichostatin A	43-46	SMAD family member 3	Homo sapiens	130-135	
23013422-5	2013	In addition, TSA significantly upregulated the levels of phospho-Smad2/3, Smad4, and nuclear factor I-C, while the specific inhibitor of Smad3 inhibits TSA enhancing mineralization differentiation of hDPSCs.	trichostatin A	152-155	SMAD family member 3	Homo sapiens	137-142	
16876108-5	2006	We also found that TSA, a HDAC inhibitor that stimulates histone acetylation of the SM22alpha locus, further enhances the transactivational activity of Smad2, Smad3 and Smad4, and relieves the inhibitory effect of Smad6, Smad7, and the dominant negative mutants of Smads.	trichostatin A	19-22	SMAD family member 3	Homo sapiens	159-164	
18466073-9	2008	Further studies using deletion constructs and trichostatin A treatment showed that the full-length smad3 was necessary, and the suppression involved recruitment of histone deacetylase to the promoter.	trichostatin A	46-60	SMAD family member 3	Homo sapiens	99-104	
12226080-5	2002	The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR.	trichostatin A	106-120	SMAD family member 3	Homo sapiens	17-22	
12226080-5	2002	The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR.	trichostatin A	106-120	SMAD family member 3	Homo sapiens	152-157	
12226080-5	2002	The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR.	trichostatin A	106-120	SMAD family member 3	Homo sapiens	152-157