PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23013422-5 2013 In addition, TSA significantly upregulated the levels of phospho-Smad2/3, Smad4, and nuclear factor I-C, while the specific inhibitor of Smad3 inhibits TSA enhancing mineralization differentiation of hDPSCs. trichostatin A 152-155 SMAD family member 3 Homo sapiens 137-142 20553909-6 2010 Our results show, for the first time, that TSA inhibits TGF-beta1-induced ERK activation and overrides pro-apoptotic signals like Smad3 and p38 in human RPTECs. trichostatin A 43-46 SMAD family member 3 Homo sapiens 130-135 18466073-9 2008 Further studies using deletion constructs and trichostatin A treatment showed that the full-length smad3 was necessary, and the suppression involved recruitment of histone deacetylase to the promoter. trichostatin A 46-60 SMAD family member 3 Homo sapiens 99-104 16876108-5 2006 We also found that TSA, a HDAC inhibitor that stimulates histone acetylation of the SM22alpha locus, further enhances the transactivational activity of Smad2, Smad3 and Smad4, and relieves the inhibitory effect of Smad6, Smad7, and the dominant negative mutants of Smads. trichostatin A 19-22 SMAD family member 3 Homo sapiens 159-164 12226080-5 2002 The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR. trichostatin A 106-120 SMAD family member 3 Homo sapiens 17-22 12226080-5 2002 The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR. trichostatin A 106-120 SMAD family member 3 Homo sapiens 152-157 12226080-5 2002 The influence of Smad3/Smad4 on the AR transactivation may involve the acetylation since the treatment of trichostatin A or sodium butyrate can reverse Smad3/Smad4-repressed AR transactivation and Smad3/Smad4 complex can also decrease the acetylation level of AR. trichostatin A 106-120 SMAD family member 3 Homo sapiens 152-157