PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2646038-4 1989 Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors. Phospholipids 82-95 insulin Homo sapiens 121-128 2667929-0 1989 Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance. Phospholipids 18-30 insulin Homo sapiens 52-59 2667929-0 1989 Potential role of phospholipid-signaling systems in insulin action and states of clinical insulin resistance. Phospholipids 18-30 insulin Homo sapiens 90-97 2602353-3 1989 In children with manifest DM the ratio of lipid, phospholipid and lipoprotein fractions was disturbed and depended upon a degree of compensation, a period of disease and a dose of insulin. Phospholipids 49-61 insulin Homo sapiens 180-187 2659084-4 1989 Insulin was also found to increase the incorporation of phosphate into phospholipids, but only if its concentration was at least 100-times higher than that of IGF-I. Phospholipids 71-84 insulin Homo sapiens 0-7 2646038-0 1989 Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men. Phospholipids 83-96 insulin Homo sapiens 0-7 2505889-0 1989 [Insulin-phospholipid interactions. Phospholipids 9-21 insulin Homo sapiens 1-8 3057893-0 1988 Phospholipid signaling systems in insulin action. Phospholipids 0-12 insulin Homo sapiens 34-41 3057893-4 1988 All three phospholipid effects of insulin also generate diacylglycerol, which activates protein kinase C, and this may contribute to insulin effects on glucose transport, ion and amino acid transport, protein synthesis, and gene expression (messenger RNA synthesis). Phospholipids 10-22 insulin Homo sapiens 34-41 3057893-4 1988 All three phospholipid effects of insulin also generate diacylglycerol, which activates protein kinase C, and this may contribute to insulin effects on glucose transport, ion and amino acid transport, protein synthesis, and gene expression (messenger RNA synthesis). Phospholipids 10-22 insulin Homo sapiens 133-140 3057893-6 1988 Moreover, the three phospholipid effects of insulin appear to be coordinated, and may function as an integrated cycle to ensure the continued synthesis of lipids, which are the sources of the signaling substances during insulin action. Phospholipids 20-32 insulin Homo sapiens 44-51 3057893-6 1988 Moreover, the three phospholipid effects of insulin appear to be coordinated, and may function as an integrated cycle to ensure the continued synthesis of lipids, which are the sources of the signaling substances during insulin action. Phospholipids 20-32 insulin Homo sapiens 220-227 2643754-2 1989 The relationship was evaluated between the proportions of individual fatty acids (FA) in serum phospholipids and (1) insulin secretion, determined by fasting and postglucose plasma insulin levels, and (2) in vivo insulin action, assessed as metabolic clearance rates of glucose during euglycemic clamp studies at two insulin concentrations of approximately 70 microU/mL (MCRglu70) and 500 microU/mL (MCRglu500). Phospholipids 95-108 insulin Homo sapiens 117-124 2505889-5 1989 The results clearly indicate the existence of two types of phospholipid-insulin interactions namely: adsorption and penetration. Phospholipids 59-71 insulin Homo sapiens 72-79 2533981-5 1989 We found a significant negative correlation between specific insulin binding and the proportion of n-6 essential FA in erythrocyte membrane phospholipids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05). Phospholipids 140-153 insulin Homo sapiens 61-68 2533981-10 1989 The data presented support the hypothesis that the FA pattern of membrane total phospholipids may modify the properties of insulin receptors. Phospholipids 80-93 insulin Homo sapiens 123-130 3286349-6 1988 This suggests that insulin regulation of specific mRNA levels may be mediated by insulin-induced changes in phospholipid metabolism and that diacylglycerol may play a pivotal role in insulin regulation of gene expression. Phospholipids 108-120 insulin Homo sapiens 19-26 3288620-1 1988 We have previously demonstrated that insulin stimulates glycerolipid synthesis and phospholipid hydrolysis in BC3H-1 myocytes, resulting in the generation of membrane diacylglycerol, a known cellular mediator. Phospholipids 83-95 insulin Homo sapiens 37-44 3286349-6 1988 This suggests that insulin regulation of specific mRNA levels may be mediated by insulin-induced changes in phospholipid metabolism and that diacylglycerol may play a pivotal role in insulin regulation of gene expression. Phospholipids 108-120 insulin Homo sapiens 81-88 3286349-6 1988 This suggests that insulin regulation of specific mRNA levels may be mediated by insulin-induced changes in phospholipid metabolism and that diacylglycerol may play a pivotal role in insulin regulation of gene expression. Phospholipids 108-120 insulin Homo sapiens 81-88 3279941-5 1988 After insulin therapy there was a decrease of very low density lipoprotein (VLDL) triglyceride (-60%, p less than 0.001) but an increase of HDL2 cholesterol (+21%, p less than 0.001); HDL2 phospholipids (+38%, p less than 0.001); HDL2 proteins (+23%, p less than 0.01); and HDL2 mass (127 +/- 11 vs. 158 +/- 12 mg/dl, p less than 0.001). Phospholipids 189-202 insulin Homo sapiens 6-13 3320694-4 1987 It is hypothesized that dietary enrichment with omega 3 fatty acids increases the incorporation of these fatty acids into the beta cell phospholipid membrane thus enhancing insulin secretion. Phospholipids 136-148 insulin Homo sapiens 173-180 3119405-7 1987 A significant positive correlation between insulin binding and cholesterol-phospholipid ratios was seen at all durations of treatment. Phospholipids 75-87 insulin Homo sapiens 43-50 2829843-0 1987 Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase. Phospholipids 0-12 insulin Homo sapiens 68-75 2829843-9 1987 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. Phospholipids 29-41 insulin Homo sapiens 57-64 3107122-2 1987 When [3H]arachidonate labeling of phospholipids was used as an indicator of phospholipase C activation, transient increases in [3H]diacylglycerol were observed between 0.5 and 10 minutes after the onset of insulin treatment. Phospholipids 34-47 insulin Homo sapiens 206-213 3107122-8 1987 Both phospholipid effects of insulin seem important for generating diacylglycerol and other phospholipid-derived intracellular signaling substances. Phospholipids 5-17 insulin Homo sapiens 29-36 3107122-8 1987 Both phospholipid effects of insulin seem important for generating diacylglycerol and other phospholipid-derived intracellular signaling substances. Phospholipids 92-104 insulin Homo sapiens 29-36 2996436-9 1985 Based on the localization of the enzyme activity in the insulin secretory granule fraction, it is proposed that phospholipid methylation plays a role in coupling the stimulus to the initial events in insulin secretion, leading to the exocytosis of insulin. Phospholipids 112-124 insulin Homo sapiens 56-63 3546313-8 1987 The early insulin-induced increases in membrane protein kinase C activity may be related to increased diacylglycerol generation from de novo phosphatidic acid synthesis, as there were rapid increases in [3H]glycerol incorporation into diacylglycerol, and transient increases in phospholipid hydrolysis, as there were transient rapid increases in [3H]diacylglycerol in cells prelabeled with [3H]arachidonate. Phospholipids 278-290 insulin Homo sapiens 10-17 3535899-9 1986 These findings indicate that the insulin secretagogue D-glucose induces phospholipid hydrolysis in islets and suggest that PC may be the major source of free arachidonate which accumulates in glucose-stimulated islets. Phospholipids 72-84 insulin Homo sapiens 33-40 3536905-0 1986 Fusion of negatively charged phospholipid vesicles by insulin. Phospholipids 29-41 insulin Homo sapiens 54-61 3517555-2 1986 [14C]acetate incorporation into total lipids, cholesterol, and phospholipids was significantly increased in familial hypercholesterolemic cells at insulin concentrations of 0.4 and 4 ng/mL, which had no effect in normal cells. Phospholipids 63-76 insulin Homo sapiens 147-154 4084539-1 1985 Purified human placental insulin receptors were incorporated into small unilamellar phospholipid vesicles by the addition of n-octyl beta-glucopyranoside solubilized phospholipids, followed by removal of the detergent on a Sephadex G-50 gel filtration column and extensive dialysis. Phospholipids 84-96 insulin Homo sapiens 25-32 4084539-1 1985 Purified human placental insulin receptors were incorporated into small unilamellar phospholipid vesicles by the addition of n-octyl beta-glucopyranoside solubilized phospholipids, followed by removal of the detergent on a Sephadex G-50 gel filtration column and extensive dialysis. Phospholipids 166-179 insulin Homo sapiens 25-32 4084539-5 1985 Sucrose gradient centrifugation of insulin receptors incorporated at various protein to phospholipid mole ratios demonstrated that the insulin receptors were inserted into the phospholipid bilayer structure in a concentration-dependent manner. Phospholipids 88-100 insulin Homo sapiens 135-142 4084539-5 1985 Sucrose gradient centrifugation of insulin receptors incorporated at various protein to phospholipid mole ratios demonstrated that the insulin receptors were inserted into the phospholipid bilayer structure in a concentration-dependent manner. Phospholipids 176-188 insulin Homo sapiens 35-42 4084539-5 1985 Sucrose gradient centrifugation of insulin receptors incorporated at various protein to phospholipid mole ratios demonstrated that the insulin receptors were inserted into the phospholipid bilayer structure in a concentration-dependent manner. Phospholipids 176-188 insulin Homo sapiens 135-142 4084539-10 1985 It is concluded that when purified insulin receptors are incorporated into a phospholipid bilayer, they insert into the vesicles primarily in the same orientation as occurs in the plasma membrane of intact cells and retain insulin binding as well as insulin-stimulated beta-subunit autophosphorylating activities. Phospholipids 77-89 insulin Homo sapiens 35-42 4084539-10 1985 It is concluded that when purified insulin receptors are incorporated into a phospholipid bilayer, they insert into the vesicles primarily in the same orientation as occurs in the plasma membrane of intact cells and retain insulin binding as well as insulin-stimulated beta-subunit autophosphorylating activities. Phospholipids 77-89 insulin Homo sapiens 223-230 4084539-10 1985 It is concluded that when purified insulin receptors are incorporated into a phospholipid bilayer, they insert into the vesicles primarily in the same orientation as occurs in the plasma membrane of intact cells and retain insulin binding as well as insulin-stimulated beta-subunit autophosphorylating activities. Phospholipids 77-89 insulin Homo sapiens 223-230 3724452-6 1986 Prior to treatment, for all subjects there was a significant inverse correlation between insulin tracer binding and membrane cholesterol/phospholipid ratios (r = .484, n = 34, P less than 0.005). Phospholipids 137-149 insulin Homo sapiens 89-96 2996436-9 1985 Based on the localization of the enzyme activity in the insulin secretory granule fraction, it is proposed that phospholipid methylation plays a role in coupling the stimulus to the initial events in insulin secretion, leading to the exocytosis of insulin. Phospholipids 112-124 insulin Homo sapiens 200-207 6373768-3 1984 Insulin-induced increases in phospholipids were significant within 5 min and near-maximal at 15-30 min. Phospholipids 29-42 insulin Homo sapiens 0-7 3890958-8 1985 Both the methyl group incorporation into membrane phospholipids and the effect on insulin binding were dependent on the S-adenosyl-L-methionine concentration used and were partially suppressed in the presence of S-adenosyl-L-homocysteine, a specific competitive inhibitor of the methyltransferases activity. Phospholipids 50-63 insulin Homo sapiens 82-89 6373768-8 1984 These findings suggest that: (a) insulin provokes rapid increases in de novo synthesis of phosphatidic acid and its derivatives, e.g. phosphoinositides and diacylglycerol; (b) protein synthesis inhibitors diminish phospholipid levels in insulin-treated (but not control) tissues by increasing phospholipid degradation (?phospholipase(s) activation); and (c) changes in phospholipids and diacylglycerol may be important for changes in pyruvate dehydrogenase and other enzymatic activities during treatment with insulin and/or protein synthesis inhibitors. Phospholipids 214-226 insulin Homo sapiens 33-40 6373768-8 1984 These findings suggest that: (a) insulin provokes rapid increases in de novo synthesis of phosphatidic acid and its derivatives, e.g. phosphoinositides and diacylglycerol; (b) protein synthesis inhibitors diminish phospholipid levels in insulin-treated (but not control) tissues by increasing phospholipid degradation (?phospholipase(s) activation); and (c) changes in phospholipids and diacylglycerol may be important for changes in pyruvate dehydrogenase and other enzymatic activities during treatment with insulin and/or protein synthesis inhibitors. Phospholipids 293-305 insulin Homo sapiens 33-40 6373768-8 1984 These findings suggest that: (a) insulin provokes rapid increases in de novo synthesis of phosphatidic acid and its derivatives, e.g. phosphoinositides and diacylglycerol; (b) protein synthesis inhibitors diminish phospholipid levels in insulin-treated (but not control) tissues by increasing phospholipid degradation (?phospholipase(s) activation); and (c) changes in phospholipids and diacylglycerol may be important for changes in pyruvate dehydrogenase and other enzymatic activities during treatment with insulin and/or protein synthesis inhibitors. Phospholipids 369-382 insulin Homo sapiens 33-40 6197974-5 1983 64.10(-4) mole of insulin per mole of phospholipid; the integrity of these vesicles is not modified as confirmed by spin resonance analysis. Phospholipids 38-50 insulin Homo sapiens 18-25 6355085-9 1983 EGF also suppressed stimulation of lipogenesis by insulin, measured as incorporation of [1-14C]acetate into triglycerides and phospholipids. Phospholipids 126-139 insulin Homo sapiens 50-57 6373768-5 1984 These insulin effects (as per prolonged pulse-chase experiments) were due to increase phospholipid synthesis rather than decreased phospholipid degradation. Phospholipids 86-98 insulin Homo sapiens 6-13 6373768-5 1984 These insulin effects (as per prolonged pulse-chase experiments) were due to increase phospholipid synthesis rather than decreased phospholipid degradation. Phospholipids 131-143 insulin Homo sapiens 6-13 6373768-6 1984 Cycloheximide (and puromycin) pretreatment prevented insulin-induced increases in phospholipids and rapidly reversed ongoing insulin effects on phospholipids and pyruvate dehydrogenase activity. Phospholipids 82-95 insulin Homo sapiens 53-60 6373768-6 1984 Cycloheximide (and puromycin) pretreatment prevented insulin-induced increases in phospholipids and rapidly reversed ongoing insulin effects on phospholipids and pyruvate dehydrogenase activity. Phospholipids 144-157 insulin Homo sapiens 53-60 6373768-6 1984 Cycloheximide (and puromycin) pretreatment prevented insulin-induced increases in phospholipids and rapidly reversed ongoing insulin effects on phospholipids and pyruvate dehydrogenase activity. Phospholipids 144-157 insulin Homo sapiens 125-132 6341537-5 1983 For phospholipids, both the nonpolar and polar regions influenced the degree of interaction with insulin. Phospholipids 4-17 insulin Homo sapiens 97-104 7005057-1 1980 The effect of insulin secretion on the turnover of phospholipids in the pancreatic beta-cell was determined by following the fate, during secretion, of phospholipids prelabelled with 3H-glycerol. Phospholipids 51-64 insulin Homo sapiens 14-21 6367855-4 1983 [32Pi] incorporation into phospholipids is also stimulated by insulin. Phospholipids 26-39 insulin Homo sapiens 62-69 7005057-2 1980 The secretion of insulin in response to glucose (20mM) plus isobutyl-methylxanthine (0.5mM) was associated with a calcium dependent increase in the turnover of the major classes of phospholipids and an increase production of 1:2 diacylglycerol and triacylglycerol. Phospholipids 181-194 insulin Homo sapiens 17-24 7005057-5 1980 The results of this study suggest that there are marked changes in the phospholipid composition of the beta-cell during insulin secretion. Phospholipids 71-83 insulin Homo sapiens 120-127 582421-0 1978 Insulin effect on the biosynthesis of lung phospholipids and their fatty acid composition. Phospholipids 43-56 insulin Homo sapiens 0-7 857812-6 1977 Exposure of arterial tissue to insulin results in proliferation of smooth muscle cells, inhibition of lipolysis, and synthesis of cholesterol, phospholipid and triglyceride. Phospholipids 143-155 insulin Homo sapiens 31-38 165982-3 1975 The participation of membrane phospholipids in the binding of insulin and the role of sialic acid residues in the transmission of the insulin binding signal are discussed. Phospholipids 30-43 insulin Homo sapiens 62-69 5158903-7 1971 Formation of insulin-phospholipid complex was confirmed by paper chromatography. Phospholipids 21-33 insulin Homo sapiens 13-20 5158903-9 1971 The two-phase system was adapted to act as a simple functional system with which to investigate possible effects of insulin on the structural and functional properties of phospholipid micelles in chloroform, by using the distribution of [(14)C]glucose between the two phases as a monitor of phospholipid-insulin interactions. Phospholipids 171-183 insulin Homo sapiens 116-123 5158903-13 1971 The significance of these results and the molecular requirements for the formation of insulin-phospholipid complexes in chloroform are discussed. Phospholipids 94-106 insulin Homo sapiens 86-93 33129101-0 2021 Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. Phospholipids 97-110 insulin Homo sapiens 114-121 5158903-0 1971 The interaction of insulin with phospholipids. Phospholipids 32-45 insulin Homo sapiens 19-26 5158903-2 1971 A simple two-phase chloroform-aqueous buffer system was used to investigate the interaction of insulin with phospholipids and other amphipathic substances. Phospholipids 108-121 insulin Homo sapiens 95-102 5492824-0 1970 Interaction of insulin with phospholipid in a membrane model. Phospholipids 28-40 insulin Homo sapiens 15-22 33129101-4 2021 Amyloidogenesis of insulin is significantly affected by DDM in a time-and dose-dependent manner, but only slightly affected by either of phospholipids. Phospholipids 137-150 insulin Homo sapiens 19-26 31101783-10 2019 The complex of essential phospholipids as additional component for diet showed an effective decrease in the severity of hepatic steatosis in combination with the reduction of insulin resistance, as well as the restoration of normal pathogenetic functional links between HDL and endothelial lipase in patients with NAFLD on background of hypertension. Phospholipids 25-38 insulin Homo sapiens 175-182 32597266-0 2020 Factors affecting the buccal delivery of deformable nanovesicles based on insulin-phospholipid complex: an in vivo investigation. Phospholipids 82-94 insulin Homo sapiens 74-81 31118622-2 2019 Methods: Insulin-phospholipid complex (IPC) was firstly prepared by an anhydrous co-solvent lyophilization method, and then encapsulated into the oil phase of nanoemulsion to obtain the IPC-based nanoemulsion (IPC-NE). Phospholipids 17-29 insulin Homo sapiens 9-16 31841777-1 2020 A fifteen-components model membrane that reflected the 80 % of phospholipids present in Insulin Secretory Granules was obtained and thermodynamic exploitation was performed, through micro-DSC, in order to assess the synergic contributions to the stability of a mixed complex system very close to real membranes. Phospholipids 63-76 insulin Homo sapiens 88-95 30616110-0 2019 Injectable and biodegradable phospholipid-based phase separation gel for sustained delivery of insulin. Phospholipids 29-41 insulin Homo sapiens 95-102 30402908-0 2019 The relationship between phospholipids and insulin resistance: From clinical to experimental studies. Phospholipids 25-38 insulin Homo sapiens 43-50 32694809-4 2019 ELOVL6 promotes an increase in phospholipid oleic acid, which modifies plasma membrane fluidity and enhances insulin signalling. Phospholipids 31-43 insulin Homo sapiens 109-116 29202465-1 2018 The incorporation of excess saturated free fatty acids (SFAs) into membrane phospholipids within the ER promotes ER stress, insulin resistance, and hepatic gluconeogenesis. Phospholipids 76-89 insulin Homo sapiens 124-131 30519017-0 2018 Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin. Phospholipids 55-67 insulin Homo sapiens 47-54 30519017-0 2018 Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin. Phospholipids 55-67 insulin Homo sapiens 109-116 30519017-4 2018 Materials and methods: Insulin-phospholipid complex combined with deformable nanovesicles (IPC-DNVs) were prepared, using deformable nanovesicles based on insulin (INS-DNVs) and conventional nanovesicles based on insulin-phospholipid complex (IPC-NVs) as references. Phospholipids 31-43 insulin Homo sapiens 23-30 30519017-4 2018 Materials and methods: Insulin-phospholipid complex combined with deformable nanovesicles (IPC-DNVs) were prepared, using deformable nanovesicles based on insulin (INS-DNVs) and conventional nanovesicles based on insulin-phospholipid complex (IPC-NVs) as references. Phospholipids 31-43 insulin Homo sapiens 155-162 30519017-4 2018 Materials and methods: Insulin-phospholipid complex combined with deformable nanovesicles (IPC-DNVs) were prepared, using deformable nanovesicles based on insulin (INS-DNVs) and conventional nanovesicles based on insulin-phospholipid complex (IPC-NVs) as references. Phospholipids 31-43 insulin Homo sapiens 213-220 30519017-4 2018 Materials and methods: Insulin-phospholipid complex combined with deformable nanovesicles (IPC-DNVs) were prepared, using deformable nanovesicles based on insulin (INS-DNVs) and conventional nanovesicles based on insulin-phospholipid complex (IPC-NVs) as references. Phospholipids 221-233 insulin Homo sapiens 23-30 30519017-13 2018 Our results and proposed mechanisms could be an important reference to understand other nanocarriers based on protein (peptide)-phospholipid complexes that penetrate the mucosa and provide a theoretical basis for the future development of buccal delivery systems for insulin. Phospholipids 128-140 insulin Homo sapiens 267-274 30228895-5 2018 Results: Increasing tissue triglyceride/phospholipid ratio was associated with increasing body mass index, fasting plasma insulin level and homeostasis model assessment as an index of insulin resistance (HOMA-IR), and also decreasing serum adiponectin level. Phospholipids 40-52 insulin Homo sapiens 122-129 30228895-5 2018 Results: Increasing tissue triglyceride/phospholipid ratio was associated with increasing body mass index, fasting plasma insulin level and homeostasis model assessment as an index of insulin resistance (HOMA-IR), and also decreasing serum adiponectin level. Phospholipids 40-52 insulin Homo sapiens 184-191 30196139-2 2018 After transformation of model protein insulin to insulin-phospholipid complex, it was dissolved together with lipid excipients in organic solvent, which was spray-dried to form solid lipid MP. Phospholipids 57-69 insulin Homo sapiens 49-56 28486917-4 2018 Vesicular phospholipid gel technique was used to encapsulate the insulin into liposomes. Phospholipids 10-22 insulin Homo sapiens 65-72 28740130-0 2017 Obesity, adipokines, and C-peptide are associated with distinct plasma phospholipid profiles in adult males, an untargeted lipidomic approach. Phospholipids 71-83 insulin Homo sapiens 25-34 29683102-5 2018 Insulin was used as the model protein; insulin-phospholipid (PL) was prepared to increase drug lipophilicity and compatibility with lipid excipients. Phospholipids 47-59 insulin Homo sapiens 39-46 29065430-5 2017 Thus, short-term recovery of insulin sensitivity after biliopancreatic diversion may, beside gut hormonal adaptation, mechanical factors, shifts in the gut microbiome, and changes in bile acid and phospholipid metabolism, additionally be attributed to a metabolic recovery of skeletal muscle cells, reflected by normalization of the cellular lipidomic profile. Phospholipids 197-209 insulin Homo sapiens 29-36 26709969-0 2016 Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults. Phospholipids 35-48 insulin Homo sapiens 66-73 26869380-4 2017 We evaluated effects of GDM and its treatment (diet or insulin) on phospholipid species, fatty acid profile in women, cord blood and placental fatty acid carriers. Phospholipids 67-79 insulin Homo sapiens 55-62 26648072-9 2017 In general, studies in humans found positive associations between higher trans-16:1n-7 proportion in plasma phospholipids and improved insulin sensitivity or decreased the onset of T2DM. Phospholipids 108-121 insulin Homo sapiens 135-142 26624532-9 2016 The interactions of Insulin with two major membrane phospholipids induces composition-dependent and long-range changes of the surface organization that ought to be considered in the context of the information-transducing capabilities of the hormone for cell functioning. Phospholipids 52-65 insulin Homo sapiens 20-27 26512026-0 2016 Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Phospholipids 16-28 insulin Homo sapiens 50-57 26512026-7 2016 In CEPT1-deficient muscles, an altered SR phospholipid milieu decreased sarco/endoplasmic reticulum Ca(2+) ATPase-dependent calcium uptake, activating calcium-signaling pathways known to improve insulin sensitivity. Phospholipids 42-54 insulin Homo sapiens 195-202 25195702-0 2014 Interaction of insulin with anionic phospholipid (DPPG) vesicles. Phospholipids 36-48 insulin Homo sapiens 15-22 25957702-8 2015 Er-Lips of ergosterol/phospholipids ratios of 1:4 or 1:6 exerts more pronounced protective ability of insulin in simulated gastrointestinal fluids and hypoglycemic effects in rats than other formulations. Phospholipids 22-35 insulin Homo sapiens 102-109 25762724-0 2015 Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation. Phospholipids 20-33 insulin Homo sapiens 37-44 25762724-9 2015 The results indicate that ISG phospholipids are in a dynamic state and are consistent with the idea that changes in ISG phospholipids facilitate fusion of ISG with the plasma membrane-enhancing glucose-stimulated insulin exocytosis. Phospholipids 30-43 insulin Homo sapiens 213-220 25762724-9 2015 The results indicate that ISG phospholipids are in a dynamic state and are consistent with the idea that changes in ISG phospholipids facilitate fusion of ISG with the plasma membrane-enhancing glucose-stimulated insulin exocytosis. Phospholipids 120-133 insulin Homo sapiens 213-220 25455781-2 2014 The SNEDDS preconcentrates, loaded with insulin-phospholipid complex at different levels (0, 2.5 and 10% w/w), were readily dispersed in water to form nanoemulsions of 35 nm and vesicles of 300 nm. Phospholipids 48-60 insulin Homo sapiens 40-47 25455781-3 2014 The association efficiency of non-complexed insulin in the dispersed SNEDDS was 18.6%, and was increased to 73.1% for insulin-phospholipid complex (at 10% loading level). Phospholipids 126-138 insulin Homo sapiens 44-51 25455781-3 2014 The association efficiency of non-complexed insulin in the dispersed SNEDDS was 18.6%, and was increased to 73.1% for insulin-phospholipid complex (at 10% loading level). Phospholipids 126-138 insulin Homo sapiens 118-125 25455781-8 2014 This study shows the effectiveness of combining SNEDDS (loaded with insulin-phospholipid complex) with enteric-coated capsules for enhancing the oral absorption and efficacy of insulin. Phospholipids 76-88 insulin Homo sapiens 68-75 25455781-8 2014 This study shows the effectiveness of combining SNEDDS (loaded with insulin-phospholipid complex) with enteric-coated capsules for enhancing the oral absorption and efficacy of insulin. Phospholipids 76-88 insulin Homo sapiens 177-184 24740208-8 2014 Phospholipid trans-16:1n-7 was also positively associated with hepatic and systemic insulin sensitivity. Phospholipids 0-12 insulin Homo sapiens 84-91 24927647-1 2014 AIMS: To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Phospholipids 52-64 insulin Homo sapiens 121-128 24927647-1 2014 AIMS: To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Phospholipids 65-100 insulin Homo sapiens 121-128 24927647-1 2014 AIMS: To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Phospholipids 102-115 insulin Homo sapiens 121-128 24927647-8 2014 CONCLUSIONS: Serum phospholipid omega-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance. Phospholipids 19-31 insulin Homo sapiens 147-154 24748573-0 2014 Association between plasma phospholipids and insulin-related variables with special reference to statistical validity. Phospholipids 27-40 insulin Homo sapiens 45-52 24153346-2 2014 OBJECTIVE: We determined whether certain phospholipid species and fatty acids that are associated with full-fat dairy consumption may also be linked to diminished insulin resistance. Phospholipids 41-53 insulin Homo sapiens 163-170 24153346-11 2014 CONCLUSION: Variables of insulin resistance were lower at higher concentrations of specific plasma phospholipids that were also indicators of full-fat dairy consumption. Phospholipids 99-112 insulin Homo sapiens 25-32 22112760-0 2012 A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Phospholipids 59-71 insulin Homo sapiens 28-35 23901139-9 2013 These findings reveal a phospholipid-dependent mechanism that suppresses insulin signaling downstream of its receptor. Phospholipids 24-36 insulin Homo sapiens 73-80 23775014-0 2013 Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Phospholipids 59-72 insulin Homo sapiens 101-108 23775014-15 2013 CONCLUSION: We demonstrated that the insulin-sensitizing effect of a vegetarian diet might be related to the increased proportion of LA in serum phospholipids. Phospholipids 145-158 insulin Homo sapiens 37-44 22975396-0 2012 The interaction of insulin, glucose, and insulin-glucose mixtures with a phospholipid monolayer. Phospholipids 73-85 insulin Homo sapiens 19-26 22975396-1 2012 We determined how glucose or insulin interacts with a phospholipid monolayer at the air/water interface and explained these mechanisms from a physico-chemical point of view. Phospholipids 54-66 insulin Homo sapiens 29-36 22975396-4 2012 Glucose adsorbed to the underside of the DPPC monolayer, while insulin was able to penetrate through the monolayer when the phospholipid molecules were not densely packed. Phospholipids 124-136 insulin Homo sapiens 63-70 22698081-2 2012 Important outcomes of the reviewed studies appear to support the hypotheses that the flexibility of a membrane determined by the ratio of (poly)unsaturated to saturated fatty acyl chains of its phospholipids influences the effectiveness of glucose transport by insulin-independent glucose transporters (GLUTs) and the insulin-dependent GLUT4, and from the prediabetic stage on a shift from unsaturated towards saturated fatty acyl chains of membrane phospholipids directly induces a decrease in glucose effectiveness and insulin sensitivity. Phospholipids 194-207 insulin Homo sapiens 261-268 22698081-2 2012 Important outcomes of the reviewed studies appear to support the hypotheses that the flexibility of a membrane determined by the ratio of (poly)unsaturated to saturated fatty acyl chains of its phospholipids influences the effectiveness of glucose transport by insulin-independent glucose transporters (GLUTs) and the insulin-dependent GLUT4, and from the prediabetic stage on a shift from unsaturated towards saturated fatty acyl chains of membrane phospholipids directly induces a decrease in glucose effectiveness and insulin sensitivity. Phospholipids 194-207 insulin Homo sapiens 318-325 22833363-0 2012 The preparation of a complex of insulin-phospholipids and their interaction mechanism. Phospholipids 40-53 insulin Homo sapiens 32-39 22833363-3 2012 In this paper, we developed a novel technique to fabricate the insulin-phospholipids complex by a solvent evaporation method with the aim of improving the lipophilicity of insulin. Phospholipids 71-84 insulin Homo sapiens 63-70 22833363-3 2012 In this paper, we developed a novel technique to fabricate the insulin-phospholipids complex by a solvent evaporation method with the aim of improving the lipophilicity of insulin. Phospholipids 71-84 insulin Homo sapiens 172-179 22833363-4 2012 A systematic study on the preparation conditions of the insulin-phospholipids complex is reported in the present work. Phospholipids 64-77 insulin Homo sapiens 56-63 22833363-6 2012 The associated efficiency of the phospholipids and insulin can be up to 100% when their mass ratio is 7.5 : 1 or more, and the solubility of the complex is improved more than 40 000 times compared with that of insulin alone in the n-octyl alcohol. Phospholipids 33-46 insulin Homo sapiens 210-217 22833363-8 2012 The stability results showed that the complex was stable for 1 year at -20 C. The interaction mechanism of this formation is that the peptide bonds of insulin interact with the water-soluble head of phospholipids, forming a reverse micelle-like structure. Phospholipids 200-213 insulin Homo sapiens 152-159 24253370-7 2013 This is the first report to reveal compositional changes in phospholipid molecular species in chronic exercise and high-fat-diet-induced insulin-resistant models. Phospholipids 60-72 insulin Homo sapiens 137-144 22112760-1 2012 The application of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) for sustained and controlled delivery of hydrophilic insulin was made possible by preparing insulin phospholipid complex loaded biodegradable PHBHHx nanoparticles (INS-PLC-NPs). Phospholipids 170-182 insulin Homo sapiens 123-130 22414059-5 2012 In addition, ROS activate UCP2 via peroxidation of the mitochondrial membrane phospholipids, which results in proton leak leading to reduced ATP synthesis and content in beta-cells - critical parameters in the regulation of glucose-stimulated insulin secretion. Phospholipids 78-91 insulin Homo sapiens 243-250 21513558-0 2011 Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study. Phospholipids 97-109 insulin Homo sapiens 52-59 22848213-0 2012 pH-Dependent Interaction between C-Peptide and Phospholipid Bicelles. Phospholipids 47-59 insulin Homo sapiens 33-42 22848213-2 2012 In this paper, we investigate the interaction between C-peptide and phospholipid bicelles, by circular dichroism and nuclear magnetic resonance spectroscopy, and in particular the pH dependence of this interaction. Phospholipids 68-80 insulin Homo sapiens 54-63 22848213-4 2012 Furthermore, it is demonstrated that C-peptide associates with neutral phospholipid bicelles as well as acidic phospholipid bicelles at this low pH. Phospholipids 71-83 insulin Homo sapiens 37-46 22848213-4 2012 Furthermore, it is demonstrated that C-peptide associates with neutral phospholipid bicelles as well as acidic phospholipid bicelles at this low pH. Phospholipids 111-123 insulin Homo sapiens 37-46 21413848-2 2011 The conversion of dihomogamma linolenic acid (DGLA) into arachidonic acid (AA) in human plasma phospholipids has been shown to be regulated by insulin, suggesting a role for insulin in fatty acid desaturase 1 regulation. Phospholipids 95-108 insulin Homo sapiens 143-150 21413848-2 2011 The conversion of dihomogamma linolenic acid (DGLA) into arachidonic acid (AA) in human plasma phospholipids has been shown to be regulated by insulin, suggesting a role for insulin in fatty acid desaturase 1 regulation. Phospholipids 95-108 insulin Homo sapiens 174-181 21386858-9 2011 CONCLUSIONS: We postulate that membrane phospholipids fatty acids have an indirect role in determining insulin concentration but insulin has a major role in determining membrane fatty acid composition. Phospholipids 40-53 insulin Homo sapiens 103-110 21513558-1 2011 BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. Phospholipids 155-167 insulin Homo sapiens 105-112 21822379-4 2011 The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH. Phospholipids 182-194 insulin Homo sapiens 65-72 21097841-7 2011 Insulin treatment promoted an increase in levels of the signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) in plasmalemmal caveolae. Phospholipids 66-78 insulin Homo sapiens 0-7 21822379-4 2011 The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH. Phospholipids 230-242 insulin Homo sapiens 65-72 19817800-1 2009 Insulin secretion is regulated by a series of complex events generated by various intracellular signals including Ca(2+), ATP, cAMP and phospholipid-derived signals. Phospholipids 136-148 insulin Homo sapiens 0-7 19542908-6 2009 Insulin resistance was independently associated with SNP 276G>T (p = 0.002) and n - 6/n - 3 LCPUFA (p = 0.042) in plasma phospholipids, and interaction was found between SNP 276G>T and n - 6/n - 3 LCPUFA (p = 0.046). Phospholipids 121-134 insulin Homo sapiens 0-7 18578691-1 2008 BACKGROUND: Long-chain polyunsaturated fatty acid (LCPUFA) especially the n-3-FA of skeletal muscle phospholipids may facilitate insulin action, whereas saturated and trans-FA act oppositely. Phospholipids 100-113 insulin Homo sapiens 129-136 15748617-0 2005 Long-chain omega6 polyunsaturated fatty acids in erythrocyte phospholipids are associated with insulin resistance in non-obese type 2 diabetics. Phospholipids 61-74 insulin Homo sapiens 95-102 17662254-0 2008 Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic beta cell. Phospholipids 58-70 insulin Homo sapiens 116-123 17718790-4 2007 Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Phospholipids 0-12 insulin Homo sapiens 172-179 17204958-2 2007 AIM: To examine the association between fatty acid composition of adipose tissue and skeletal muscle phospholipids with insulin resistance markers in a healthy pediatric population. Phospholipids 101-114 insulin Homo sapiens 120-127 16179727-11 2005 Previous reviews from our laboratory that have appeared in the Proceedings have provided essentials on phospholipid-signaling mechanisms used by insulin to activate several protein kinases that seem to be important in mediating the metabolic effects of insulin. Phospholipids 103-115 insulin Homo sapiens 145-152 16179727-11 2005 Previous reviews from our laboratory that have appeared in the Proceedings have provided essentials on phospholipid-signaling mechanisms used by insulin to activate several protein kinases that seem to be important in mediating the metabolic effects of insulin. Phospholipids 103-115 insulin Homo sapiens 253-260 18166446-6 2008 Phospholipids provide a controlled release of the encapsulated protein (insulin), which was successfully associated to the system (68%). Phospholipids 0-13 insulin Homo sapiens 72-79 17095403-10 2006 CONCLUSION: The combination of increased saturated/polyunsaturated fatty acids, increased saturated nature, and increased cholesterol/phospholipid can contribute to decreased membrane fluidity, resulting in insulin resistance. Phospholipids 134-146 insulin Homo sapiens 207-214 16430716-2 2006 OBJECTIVE: Cross-sectional studies suggest that the fatty acid (FA) composition of phospholipids in skeletal muscle cell membrane may modulate insulin sensitivity in humans. Phospholipids 83-96 insulin Homo sapiens 143-150 15748617-2 2005 We evaluated whether there was an association between insulin resistance and long-chain omega6 polyunsaturated fatty acids in erythrocyte phospholipids of type 2 diabetics. Phospholipids 138-151 insulin Homo sapiens 54-61 12899657-0 2003 Involvement of phospholipids in the mechanism of insulin action in HEPG2 cells. Phospholipids 15-28 insulin Homo sapiens 49-56 15256315-0 2004 Fatty acid composition of erythrocyte phospholipids is related to insulin levels, secretion and resistance in obese type 2 diabetics on Metformin. Phospholipids 38-51 insulin Homo sapiens 66-73 15256315-3 2004 METHODS: In 23 diabetics, the fractions of the different fatty acids in erythrocyte phospholipids were correlated with insulin levels, secretion, sensitivity, resistance and insulinemic response following a standardised breakfast. Phospholipids 84-97 insulin Homo sapiens 119-126 15256315-4 2004 RESULTS: Fasting insulin levels and insulin resistance correlated positively with the fraction of alpha-linolenic and dihomo-gamma-linolenic acid and with the ratios of stearic to palmitic and dihomo-gamma-linolenic to linoleic acid and negatively with the fraction of palmitic acid in erythrocyte phospholipids. Phospholipids 298-311 insulin Homo sapiens 17-24 15256315-4 2004 RESULTS: Fasting insulin levels and insulin resistance correlated positively with the fraction of alpha-linolenic and dihomo-gamma-linolenic acid and with the ratios of stearic to palmitic and dihomo-gamma-linolenic to linoleic acid and negatively with the fraction of palmitic acid in erythrocyte phospholipids. Phospholipids 298-311 insulin Homo sapiens 36-43 14713277-13 2004 CONCLUSION: There is an association between the intake of oleic acid, the composition of oleic acid in plasma phospholipids and peripheral insulin action. Phospholipids 110-123 insulin Homo sapiens 139-146 14568435-0 2003 Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device. Phospholipids 15-27 insulin Homo sapiens 76-83 14684393-9 2004 The proportion of dihomo-gamma-linolenic acid (20:3n-6) in serum phospholipids was inversely related to insulin sensitivity both before (r = -0.48, P < 0.001) and after (r = -0.46, P < 0.001) weight loss, but it did not change significantly in either group. Phospholipids 65-78 insulin Homo sapiens 104-111 12100989-10 2002 Furthermore, while in the presence of the phospholipid, almost all the transported insulin was detected in the receiver compartment; in the absence of added lipids, only about half the insulin transported was in the receiver compartment and an almost equal amount of insulin remained in the epidermis. Phospholipids 42-54 insulin Homo sapiens 83-90 11897789-4 2002 Because the Shc PTB domain can interact with phospholipids, we postulated that PI 3-kinase might be a necessary intermediary step facilitating insulin-stimulated phosphorylation of Shc. Phospholipids 45-58 insulin Homo sapiens 143-150 11897789-7 2002 All three growth factors cause localization of Shc to the plasma membrane, but only the effect of insulin was inhibited by wortmannin, supporting the view that PI 3-kinase-generated phospholipids mediate insulin-stimulated Shc phosphorylation. Phospholipids 182-195 insulin Homo sapiens 204-211 11500316-4 2001 During muscle contraction, when total palmitate uptake was increased, insulin further enhanced uptake (+21%, P < 0.05) and esterification of fatty acids (FA) to PL (+73%, P < 0.05), DG (+19%, P < 0.05), and TG (+161%, P < 0.01). Phospholipids 164-166 insulin Homo sapiens 70-77 11588141-5 2001 These phospholipid-derived messengers, particularly diacylglycerol, activate PKC, thereby increasing the efficiency of free cytosolic Ca(2+) concentration ([Ca(2+)](c)) on exocytosis of insulin granules. Phospholipids 6-18 insulin Homo sapiens 186-193 11914740-0 2002 Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids. Phospholipids 170-183 insulin Homo sapiens 18-25 11914740-6 2002 RESULTS: Cord plasma phospholipid gamma-linolenic acid and dihomo- gamma-linolenic acid concentrations were negatively related to insulin concentrations and calculated insulin resistance (homeostasis model assessment) at seven years of age. Phospholipids 21-33 insulin Homo sapiens 130-137 11914740-6 2002 RESULTS: Cord plasma phospholipid gamma-linolenic acid and dihomo- gamma-linolenic acid concentrations were negatively related to insulin concentrations and calculated insulin resistance (homeostasis model assessment) at seven years of age. Phospholipids 21-33 insulin Homo sapiens 168-175 11124961-5 2001 Of the fatty acids examined, arachidonic acid (AA) had the greatest positive effects, significantly increasing basal and insulin-stimulated glucose uptake by 1.8- and 2-fold, respectively, with effects being maximal at 4 h at which time membrane phospholipid content of AA was markedly increased. Phospholipids 246-258 insulin Homo sapiens 121-128 11292539-2 2001 In this work, we investigated the enhancement of insulin absorption in the presence of phospholipids and lung lavage fluid in vivo and in vitro. Phospholipids 87-100 insulin Homo sapiens 49-56 11292539-6 2001 A significantly higher blood glucose decrease was observed with a DPPC-insulin physical mixture compared to liposome, suggesting a possible effect of the phospholipid chain physical state on the insulin in-vivo absorption. Phospholipids 154-166 insulin Homo sapiens 71-78 11292539-6 2001 A significantly higher blood glucose decrease was observed with a DPPC-insulin physical mixture compared to liposome, suggesting a possible effect of the phospholipid chain physical state on the insulin in-vivo absorption. Phospholipids 154-166 insulin Homo sapiens 195-202 11368419-0 2001 Insulin-sensitive phospholipid signaling systems and glucose transport. Phospholipids 18-30 insulin Homo sapiens 0-7 11368419-2 2001 Insulin provokes rapid changes in phospholipid metabolism and thereby generates biologically active lipids that serve as intracellular signaling factors that regulate glucose transport and glycogen synthesis. Phospholipids 34-46 insulin Homo sapiens 0-7 11126212-3 2000 OBJECTIVES: (1) To study the distribution of phospholipid classes in the plasma membrane and their association with insulin resistance markers in the adipocyte, an insulin-sensitive cell in obese women. Phospholipids 45-57 insulin Homo sapiens 116-123 11172480-12 2001 Furthermore, enhancement of dihomo-gamma-linolenic and myristic acids in serum CE and PL, presumably markers for dietary intake, predicted insulin resistance. Phospholipids 86-88 insulin Homo sapiens 139-146 11126212-3 2000 OBJECTIVES: (1) To study the distribution of phospholipid classes in the plasma membrane and their association with insulin resistance markers in the adipocyte, an insulin-sensitive cell in obese women. Phospholipids 45-57 insulin Homo sapiens 164-171 11016898-1 2000 Recent studies suggest that insulin sensitivity is related to the fatty acid composition of phospholipids in skeletal muscle (SM) membranes. Phospholipids 92-105 insulin Homo sapiens 28-35 11149279-7 2000 As one important aspect if skeletal muscle has a high capacity for lipid oxidation, then more saturated fatty acids are oxidised and more unsaturated fatty acids are built in the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Phospholipids 179-191 insulin Homo sapiens 262-269 10787432-3 2000 Insulin stimulation of fatty acid incorporation into triglyceride (TG) was also less pronounced in hepatocytes from the FO-fed group than in those from the OO-fed group but there was no difference in the stimulatory effect of insulin on fatty acid incorporation into phospholipid (PL) in these two groups. Phospholipids 267-279 insulin Homo sapiens 0-7 10893319-7 2000 Diabetes-induced changes in PLA(2) activity, lysophospholipid production, and alterations in phospholipid composition were all reversed by insulin treatment of diabetic animals. Phospholipids 49-61 insulin Homo sapiens 139-146 10832054-3 2000 However, the membrane"s physiochemical properties, as determined by phospholipid composition, have been related to insulin action in animal and human studies and CR has been reported to alter membrane lipid content. Phospholipids 68-80 insulin Homo sapiens 115-122 10787432-3 2000 Insulin stimulation of fatty acid incorporation into triglyceride (TG) was also less pronounced in hepatocytes from the FO-fed group than in those from the OO-fed group but there was no difference in the stimulatory effect of insulin on fatty acid incorporation into phospholipid (PL) in these two groups. Phospholipids 281-283 insulin Homo sapiens 0-7 9439543-8 1997 Our results indicate that the beneficial effect of EPA-E on insulin resistance in OLETF rats is likely to be dependent on modification of the phospholipid components of the skeletal muscle membrane. Phospholipids 142-154 insulin Homo sapiens 60-67 10501653-7 1999 Although all the elements within the type II diabetes phenotype have not been fully defined, it has been proposed that defects in insulin transmembrane signaling through malfunction of inositol-containing phospholipid metabolism and absenteeism of the generation of phospholipid-derived second messengers may be associated with the appearance of the type II diabetic phenotype. Phospholipids 205-217 insulin Homo sapiens 130-137 10501653-7 1999 Although all the elements within the type II diabetes phenotype have not been fully defined, it has been proposed that defects in insulin transmembrane signaling through malfunction of inositol-containing phospholipid metabolism and absenteeism of the generation of phospholipid-derived second messengers may be associated with the appearance of the type II diabetic phenotype. Phospholipids 266-278 insulin Homo sapiens 130-137 10513036-7 1999 The different factors that may impair insulin action and alter glucose uptake in skeletal muscle are: lower blood flow to muscle, produced by either decreased vasodilation or by increased sympathetic nerve activity; augmented diffusion distance from capillaries to muscle due to a decrease in capillary number or to enlarged muscle cells; decrease of insulin receptors; change in the fatty acid profile of major membrane structural phospholipids; decrease in glucose transporters (GLUT 4) and/or hexokinase; impairment in metabolic routes of glucose in muscle as reduction in glycogen synthase. Phospholipids 432-445 insulin Homo sapiens 38-45 10776058-7 2000 An important aspect is that when skeletal muscle has a high capacity for lipid oxidation more saturated fatty acids are oxidized and more unsaturated fatty acids are built into the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Phospholipids 181-193 insulin Homo sapiens 264-271 10690951-4 2000 However, it has been more difficult to determine if changes in insulin sensitivity are associated with changes in the skeletal muscle membrane fatty acid composition of PL in man. Phospholipids 169-171 insulin Homo sapiens 63-70 9891043-13 1999 In summary, our results show that expression of SHIP inhibits insulin-induced GLUT4 translocation, growth factor-induced membrane ruffling, and DNA synthesis, indicating that PtdIns 3,4,5-P3 is the key phospholipid product mediating these biological actions. Phospholipids 202-214 insulin Homo sapiens 62-69 9755086-1 1998 The fatty acid composition of skeletal muscle membrane phospholipids (PL) is known to influence insulin responsiveness in humans. Phospholipids 55-68 insulin Homo sapiens 96-103 9755086-1 1998 The fatty acid composition of skeletal muscle membrane phospholipids (PL) is known to influence insulin responsiveness in humans. Phospholipids 70-72 insulin Homo sapiens 96-103 9530125-7 1998 We conclude that regular low-intensity exercise influences the fatty acid composition of the phospholipids in skeletal muscle, which hypothetically may contribute to changes of the skeletal muscle membrane fluidity and influence the peripheral insulin sensitivity. Phospholipids 93-106 insulin Homo sapiens 244-251 9781321-2 1998 Insulin sensitivity relates to the fatty acid composition of the skeletal muscle phospholipids and the intramuscular triglyceride content. Phospholipids 81-94 insulin Homo sapiens 0-7 9440487-2 1998 Low levels of DHA and other LCPUFAs in skeletal muscle membrane phospholipid are associated with insulin resistance and obesity in adults. Phospholipids 64-76 insulin Homo sapiens 97-104 9440487-12 1998 Early changes in skeletal muscle membrane phospholipid FA saturation may play a role in the subsequent development of diseases associated with insulin resistance. Phospholipids 42-54 insulin Homo sapiens 143-150 8954133-0 1996 Stimulation of phospholipid synthesis in HeLa cells by epidermal growth factor and insulin: activation of choline kinase and glycerophosphate acyltransferase. Phospholipids 15-27 insulin Homo sapiens 83-90 9430382-11 1997 The n-6 PUFAs are a bit of a worry: while arachidonic acid levels in muscle phospholipid has linked positively to insulin action in our studies, linoleic is negative. Phospholipids 76-88 insulin Homo sapiens 114-121 8954133-2 1996 A single addition of EGF or insulin was not enough to stimulate proliferation, but still sufficient to efficiently restore the phospholipid content to the level of serum-grown cells. Phospholipids 127-139 insulin Homo sapiens 28-35 8954133-3 1996 Both EGF and insulin stimulated the synthesis of major phospholipids in HeLa cells. Phospholipids 55-68 insulin Homo sapiens 13-20 8954133-8 1996 The present results provide evidence that one of the roles of EGF and insulin during cell growth is to stimulate the synthesis of phospholipids. Phospholipids 130-143 insulin Homo sapiens 70-77 8914923-4 1996 Insulin also reduced [3H]oleic acid uptake up to 35%, depending on insulin concentration and decreased the amount of fatty acid esterified into the phospholipids and neutral lipids by 28 and 70%, respectively. Phospholipids 148-161 insulin Homo sapiens 0-7 8820818-0 1996 Insulin-sensitive phospholipid signaling systems and glucose transport: an update. Phospholipids 18-30 insulin Homo sapiens 0-7 8692021-10 1996 Insulin concentrations in fasting plasma were directly related to CETP levels and to the weight-percentage of UC in HDL3, and inversely to the weight-percentage of phospholipids in LDL (all P < .05). Phospholipids 164-177 insulin Homo sapiens 0-7 8770926-0 1996 Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes. Phospholipids 104-116 insulin Homo sapiens 0-7 8770926-1 1996 Previous studies have provided conflicting findings on whether insulin activates certain, potentially important, phospholipid signaling systems in skeletal muscle preparations. Phospholipids 113-125 insulin Homo sapiens 63-70 8770926-3 1996 Presently, we examined insulin effects on phospholipid signaling systems, diacylglycerol (DAG) production, and PKC translocation/activation in L6 myotubes. Phospholipids 42-54 insulin Homo sapiens 23-30 8675650-1 1995 The cellular basis of insulin resistance is still unknown; however, relationships have been demonstrated between insulin action in muscle and the fatty acid profile of the major membrane structural lipid (phospholipid). Phospholipids 205-217 insulin Homo sapiens 113-120 8596494-4 1996 Fasting insulin was strongly and positively associated with the saturated fatty acid percentage in plasma phospholipids, moderately and inversely associated with the monounsaturated percentage, and not appreciably associated with the polyunsaturated percentage. Phospholipids 106-119 insulin Homo sapiens 8-15 8609827-0 1996 Intraperitoneal insulin infusion improves the depletion in choline-containing phospholipids of lipoprotein B particles in type I diabetic patients. Phospholipids 78-91 insulin Homo sapiens 16-23 8609827-1 1996 Insulin-dependent diabetes mellitus (IDDM) is characterized by altered composition of atherogenic lipoproteins, especially a depletion in choline-containing phospholipids (PL) of apolipoprotein (apo) B lipoproteins (LpB). Phospholipids 157-170 insulin Homo sapiens 0-7 8729130-2 1996 This paper reviews the range of evidence in humans and experimental animals demonstrating close associations between insulin action and two major aspects of muscle morphology: fatty acid composition of the major structural lipid (phospholipid) in muscle cell membranes and relative proportions of major muscle fiber types. Phospholipids 230-242 insulin Homo sapiens 117-124 8729130-3 1996 Work in vitro and in vivo in both rats and humans has shown that incorporation of more unsaturated fatty acids into muscle membrane phospholipid is associated with improved insulin action. Phospholipids 132-144 insulin Homo sapiens 173-180 8729130-7 1996 In relation to fiber type, the more highly oxidative, insulin-sensitive type 1 and type 2a fibers have a higher percentage of unsaturated fatty acids, particularly n-3, in their membrane phospholipid, compared to the insulin-resistant, glycolytic, type 2b fibers. Phospholipids 187-199 insulin Homo sapiens 54-61 8643029-0 1995 Effect of 3-amino-1-propanol, indomethacin and 4-bromophenacyl bromide on the hormone binding of insulin pretreated Tetrahymena: influence of phospholipid metabolism disturbances on hormonal imprinting. Phospholipids 142-154 insulin Homo sapiens 97-104 7851683-0 1994 Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Phospholipids 97-110 insulin Homo sapiens 0-7 7851683-7 1994 Thus, more than 51% of the variation of the insulin sensitivity was explained by an equation containing body mass index, serum triglyceride concentration and the content of palmitic acid in the skeletal muscle phospholipids. Phospholipids 210-223 insulin Homo sapiens 44-51 7851683-8 1994 It is concluded that the fatty acid composition in serum and of the phospholipids of skeletal muscle may influence insulin action in elderly men. Phospholipids 68-81 insulin Homo sapiens 115-122 8001841-3 1994 Recent findings that C20-C22 in muscle membrane phospholipids are inversely related to insulin resistance, whereas linoleic acid is positively related to insulin resistance, suggest that diet may influence the development of insulin resistance in obesity, insulin-dependent diabetes mellitus (IDDM), hypertension, and coronary artery disease (including asymptomatic atherosclerosis and microvascular angina). Phospholipids 48-61 insulin Homo sapiens 87-94 8031124-4 1994 Sodium orthovanadate was also found to activate phospholipid signaling pathways that were previously reported to be activated by insulin, viz., inositol-lipid synthesis/turnover; phosphatidylcholine hydrolysis; and de novo phospholipid synthesis by activation of glycerol-3-PO4 acyltransferase. Phospholipids 48-60 insulin Homo sapiens 129-136 8031124-4 1994 Sodium orthovanadate was also found to activate phospholipid signaling pathways that were previously reported to be activated by insulin, viz., inositol-lipid synthesis/turnover; phosphatidylcholine hydrolysis; and de novo phospholipid synthesis by activation of glycerol-3-PO4 acyltransferase. Phospholipids 223-235 insulin Homo sapiens 129-136 8031124-5 1994 Our findings suggest that vanadate mimics insulin in the activation of specific phospholipid/DAG/PKC signaling pathways. Phospholipids 80-92 insulin Homo sapiens 42-49 7939369-7 1994 In both groups combined, the recorded changes in serum triglyceride and serum insulin levels were negatively correlated with the change in serum phospholipid n-3 fatty acids (r = -0.35, p = 0.008 and r = -0.32, p = 0.016, respectively). Phospholipids 145-157 insulin Homo sapiens 78-85 7949236-8 1994 We have also demonstrated that insulin enhances the 86Rb uptake and stimulates the Na, K-ATPase activity in HPMC but on the other hand is capable of reducing the phospholipids secretion from HPMC. Phospholipids 162-175 insulin Homo sapiens 31-38 8418404-0 1993 The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. Phospholipids 91-104 insulin Homo sapiens 21-28 8356081-0 1993 Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor. Phospholipids 65-78 insulin Homo sapiens 0-7 8356081-2 1993 After phase separation, treatment with insulin for 15 min caused a 2.2-fold increase in the specific radioactivity of chiro-[3H]inositol-containing phospholipids in contrast to a 1.2-fold increase in the specific radioactivity of myo-[3H]inositol-containing phospholipids. Phospholipids 148-161 insulin Homo sapiens 39-46 8356081-2 1993 After phase separation, treatment with insulin for 15 min caused a 2.2-fold increase in the specific radioactivity of chiro-[3H]inositol-containing phospholipids in contrast to a 1.2-fold increase in the specific radioactivity of myo-[3H]inositol-containing phospholipids. Phospholipids 258-271 insulin Homo sapiens 39-46 8356081-4 1993 Further detailed analysis of individual [3H]inositol-containing phospholipids demonstrated marked increases in specific activity of the chiro-[3H]inositol phospholipids after 15 min of incubation with insulin: phosphatidylinositol 4-phosphate and 4,5-bisphosphate, 4.2-fold; lysophosphatidylinositol, 1.5-fold; phosphatidylinositol, 3.2-fold. Phospholipids 64-77 insulin Homo sapiens 201-208 8356081-5 1993 In contrast, myo-[3H]inositol-containing phospholipids demonstrated relatively small increases (1.1- to 1.4-fold) after 5 min of incubation with insulin. Phospholipids 41-54 insulin Homo sapiens 145-152 8356081-6 1993 These findings indicate that insulin stimulates de novo synthesis of chiro-inositol-containing phospholipids at the inositol phospholipid level. Phospholipids 95-108 insulin Homo sapiens 29-36 8386623-3 1993 The incorporation of lectin-purified insulin receptors was assessed by cosedimentation of 125I-insulin binding and [32P]phospholipids in a sucrose gradient. Phospholipids 120-133 insulin Homo sapiens 37-44 8386623-6 1993 Mixtures of phosphatidylcholine/phosphatidylserine or phospholipids/phosphatidylserine, in ratios of 1-4, increased the insulin-induced tyrosine kinase activation in a dose-dependent manner. Phospholipids 54-67 insulin Homo sapiens 120-127 8432406-2 1993 Insulin secretagogues also induce phospholipid hydrolysis and accumulation of phospholipid-derived mediators in islets, including the lipid messengers DAG, nonesterified arachidonic acid, and arachidonate 12-LO products. Phospholipids 34-46 insulin Homo sapiens 0-7 8432406-2 1993 Insulin secretagogues also induce phospholipid hydrolysis and accumulation of phospholipid-derived mediators in islets, including the lipid messengers DAG, nonesterified arachidonic acid, and arachidonate 12-LO products. Phospholipids 78-90 insulin Homo sapiens 0-7 8033575-9 1994 The addition of the growth factors hEGF and insulin to Optisol alters corneal metabolic activity during storage in a manner indicative of conserving corneal phospholipids. Phospholipids 157-170 insulin Homo sapiens 44-51 8257685-2 1993 Hydrolysis of membrane phospholipids also occurs in glucose-stimulated islets, resulting in accumulation of nonesterified arachidonate, which facilitates Ca2+ entry and the rise in beta-cell [Ca2+] that triggers insulin secretion. Phospholipids 23-36 insulin Homo sapiens 212-219 24234896-8 1993 Thus, the observed changes in scattered light could be interpreted in terms of the insulin association to the liposomal surface in the case of phospholipid peroxidation and/or acidic pH. Phospholipids 143-155 insulin Homo sapiens 83-90 8418404-2 1993 Skeletal muscle is a major site of insulin action, and insulin sensitivity may be related to the fatty-acid composition of the phospholipids within the muscle membranes involved in the action of insulin. Phospholipids 127-140 insulin Homo sapiens 55-62 8418404-2 1993 Skeletal muscle is a major site of insulin action, and insulin sensitivity may be related to the fatty-acid composition of the phospholipids within the muscle membranes involved in the action of insulin. Phospholipids 127-140 insulin Homo sapiens 55-62 8418404-3 1993 METHODS: We determined the relation between the fatty-acid composition of skeletal-muscle phospholipids and insulin sensitivity in two groups of subjects. Phospholipids 90-103 insulin Homo sapiens 108-115 8418404-8 1993 CONCLUSIONS: Decreased insulin sensitivity is associated with decreased concentrations of polyunsaturated fatty acids in skeletal-muscle phospholipids, raising the possibility that changes in the fatty-acid composition of muscles modulate the action of insulin. Phospholipids 137-150 insulin Homo sapiens 23-30 1600703-1 1992 The pharmacokinetics of intranasal insulin containing a medium-chain phospholipid (didecanoyl-L-alpha-phosphatidylcholine) as absorption enhancer, was studied in normal volunteers by measuring plasma glucose, insulin, C-peptide, and glucagon. Phospholipids 69-81 insulin Homo sapiens 35-42 1404494-13 1992 When cholesterol:phospholipid liposomes were added in the presence of insulin virtually all of the secreted apoE was found associated with the VLDL to IDL size particles. Phospholipids 17-29 insulin Homo sapiens 70-77 1736892-12 1992 The method of insertion of isolated insulin receptors using the natural detergent, lysophospholipid, may be a method for insertion of receptors into intact cells, where the lysophospholipid, as in the plasma-membrane vesicles, will be acylated to phospholipid. Phospholipids 87-99 insulin Homo sapiens 36-43 1903207-2 1991 The purpose of this experiment was to determine if other known stimulators of H+ excretion [insulin, deoxycorticosterone acetate (DOCA), epinephrine, parathyroid hormone, and CO2] might also stimulate PL turnover in the toad urinary bladder. Phospholipids 201-203 insulin Homo sapiens 92-99 1316358-5 1992 Further studies on the chemical structures of phospholipids and their hydrolysis products involved in insulin action will be required to sort out the underlying mechanisms of insulin action via non-tyrosine kinase dependent pathways. Phospholipids 46-59 insulin Homo sapiens 102-109 1316358-5 1992 Further studies on the chemical structures of phospholipids and their hydrolysis products involved in insulin action will be required to sort out the underlying mechanisms of insulin action via non-tyrosine kinase dependent pathways. Phospholipids 46-59 insulin Homo sapiens 175-182 1650954-3 1991 The levels of these phospholipids were unchanged at the earliest time examined, but at 30 min insulin caused an increase in the content of all phospholipids tested. Phospholipids 143-156 insulin Homo sapiens 94-101 1650954-6 1991 First, insulin causes a rapid but transient hydrolysis of phosphoinositides by a phospholipase C-dependent mechanism, followed by subsequent resynthesis; thereafter, insulin increases de novo phospholipid synthesis. Phospholipids 192-204 insulin Homo sapiens 7-14 1845144-1 1991 There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Phospholipids 61-73 insulin Homo sapiens 36-43 2404758-5 1990 The diacylglycerols also stimulated tyrosine kinase activity of the partially purified U-937 and IM-9 insulin receptors 2.5-3.5-fold when measured by phosphorylation of an exogenous substrate, poly(Glu80Tyr20) in the absence of any added insulin, calcium or phospholipid. Phospholipids 258-270 insulin Homo sapiens 102-109 1903207-10 1991 We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC. Phospholipids 127-129 insulin Homo sapiens 17-24 2176832-0 1990 Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Phospholipids 103-115 insulin Homo sapiens 0-7 2132531-1 1990 The findings reported herein indicate that insulin rapidly perturbs phospholipid metabolism and consequent intracellular signalling, in its target tissues by two fully separable mechanisms. Phospholipids 68-80 insulin Homo sapiens 43-50 33760621-0 2021 Visceral Adipose Tissue Phospholipid Signature of Insulin Sensitivity and Obesity. Phospholipids 24-36 insulin Homo sapiens 50-57 34549877-0 2021 Plasma Phospholipids with Long-Chain Polyunsaturated Fatty Acids and Dihydroceramides at the Crossroads of Iron Stores and Insulin Resistance. Phospholipids 7-20 insulin Homo sapiens 123-130 34925073-0 2021 The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans. Phospholipids 60-73 insulin Homo sapiens 4-11 34684619-0 2021 Phospholipid Derivatives of Cinnamic Acid Restore Insulin Sensitivity in Insulin Resistance in 3T3-L1 Adipocytes. Phospholipids 0-12 insulin Homo sapiens 50-57 34684619-0 2021 Phospholipid Derivatives of Cinnamic Acid Restore Insulin Sensitivity in Insulin Resistance in 3T3-L1 Adipocytes. Phospholipids 0-12 insulin Homo sapiens 73-80 34684619-4 2021 In the present study, we analyzed the effect of phospholipid derivatives of selected natural aromatic acids on insulin action and their potential use to overcome insulin resistance. Phospholipids 48-60 insulin Homo sapiens 111-118 34684619-4 2021 In the present study, we analyzed the effect of phospholipid derivatives of selected natural aromatic acids on insulin action and their potential use to overcome insulin resistance. Phospholipids 48-60 insulin Homo sapiens 162-169 35562924-8 2022 According to our data, the retromer-mediated retrograde transport, the ethanolamine metabolism, and, consequently, the endocannabinoid signaling and phospholipid metabolism were characteristic of both conditions and can be relevant pathways to understanding and treating insulin resistance. Phospholipids 149-161 insulin Homo sapiens 271-278 34372961-8 2021 Both dietary and serum omega-3 PUFAs, mainly EPA and DPA, were negatively correlated with PCOS-related parameters, such as BMI, fasting insulin, total testosterone and high-sensitivity C-reactive protein (hs-CRP), but positively correlated with follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG). Phospholipids 23-36 insulin Homo sapiens 136-143 35580189-0 2022 Unsaturation in the Fatty Acids of Phospholipids Drastically Alters the Structure and Toxicity of Insulin Aggregates Grown in Their Presence. Phospholipids 35-48 insulin Homo sapiens 98-105 35022422-7 2022 The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist-hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. Phospholipids 21-34 insulin Homo sapiens 250-257 35022422-7 2022 The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist-hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. Phospholipids 21-34 insulin Homo sapiens 273-280