PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18048487-0	2008	Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads.	Phospholipids	83-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-47	
8634277-3	1996	Cytochrome P450 2B4 was reconstituted into unilamellar phospholipid proteoliposomes (molar protein to lipid ratio 1:90).	Phospholipids	55-67	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
9130383-2	1997	It was discovered that a long wave shift occurred in the fluorescence spectra of cytochrome P450, both in solution and within phospholipid vesicles.	Phospholipids	126-138	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-96	
8052309-7	1994	The polymer acts as a mimic of the phospholipid membrane in which cytochrome P-450 resides, acting as an interface between two immiscible phases and avoiding the need for solvents or phase-transfer agents.	Phospholipids	35-47	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-82	
8624504-0	1995	The comparative study of peroxidase activity and substrate binding properties of cytochrome P450 2B4 incorporated into phospholipid vesicles with the use of two different methods.	Phospholipids	119-131	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-96	
2496984-0	1989	On the role of phospholipids in the reconstituted cytochrome P-450 system.	Phospholipids	15-28	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-66	
1472505-6	1992	Coexistence of a mobile population with an average rotational relaxation time phi of 138-577 microseconds and immobile (phi > or = 20 ms) populations of cytochrome P-450 was observed in both phospholipid vesicles and microsomes.	Phospholipids	194-206	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	156-172	
1627548-9	1992	These results suggested that the stimulation of catalytic activity by phospholipids involved increased interaction between cytochrome P-450 and the reductase.	Phospholipids	70-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	123-139	
2344454-6	1990	Incubation of the immobilized cytochrome P-450 LM 2 with sonicated liposomes composed of various phospholipids did not result in oligomer dissociation and protein translocation from the matrix to the lipid phase, although the catalytic activity of the immobilized cytochrome significantly increased in the presence of liposomes.	Phospholipids	97-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46	
2515662-2	1989	The anaerobic NADPH-reduction of the isozymes cytochrome P-450 LM2 and LM4 was used as a functional tool to study the component interaction in reconstituted monooxygenase systems in dependence on different phospholipids.	Phospholipids	206-219	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62	
2590684-1	1989	Crosslinking of protein molecules with bifunctional reagents and subsequent electrophoresis of the modified proteins revealed the presence of cytochrome P-450 LM 2 oligomers in proteoliposome membranes obtained in different ways and differing in their phospholipid composition.	Phospholipids	252-264	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	142-158	
2496984-3	1989	The hypotheses proposed in the literature for the role of phospholipids in the reconstituted cytochrome P-450 system, mainly based on the comparison of systems without phospholipid and with Lau2GroPCho, were either validated or shown to be unlikely when tested by comparing reconstituted systems with different phosphatidylcholines.	Phospholipids	58-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109	
2496984-3	1989	The hypotheses proposed in the literature for the role of phospholipids in the reconstituted cytochrome P-450 system, mainly based on the comparison of systems without phospholipid and with Lau2GroPCho, were either validated or shown to be unlikely when tested by comparing reconstituted systems with different phosphatidylcholines.	Phospholipids	58-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109	
2496984-8	1989	Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450.	Phospholipids	128-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-216	
2496984-8	1989	Furthermore, the different effects of both phosphatidylcholines on the Km and V for pentoxyresorufin not only suggest a role of phospholipids in the binding of the substrate to the active site of the cytochrome P-450 molecule, but also on the efficiency of electron transfer from NADPH-cytochrome reductase to cytochrome P-450.	Phospholipids	128-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	310-326	
2495281-6	1989	Cytochrome P-450 reduction was also examined in both phospholipid-containing and soluble systems where the LM2 and reductase were not present as a preformed complex.	Phospholipids	53-65	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16	
2806064-0	1989	[Rotational diffusion of cytochrome P-450 in a model membrane of various phospholipid composition].	Phospholipids	73-85	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-41	
3890847-5	1985	The formation of the cytochrome P-450-reductase-complex necessary for oxygen activation by transfer of electrons is dependent on the charge of the phospholipids.	Phospholipids	147-160	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-37	
6435533-0	1984	The association of cytochrome P-450 and NADPH-cytochrome P-450 reductase in phospholipid membranes.	Phospholipids	76-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-35	
3987778-5	1985	There was a significant correlation (r (Pearson"s product moment correlation coefficient) = 0.91) between the hepatic phospholipid and cytochrome P-450 concentration.	Phospholipids	118-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-151	
3987778-7	1985	The positive correlation between hepatic phospholipids and drug-metabolizing enzymes could be interpreted as indicating that in human liver phospholipid and cytochrome P-450 synthesis share common regulators, or that phospholipids are necessary for the maximum rate of cytochrome P-450 synthesis.	Phospholipids	41-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-173	
3987778-7	1985	The positive correlation between hepatic phospholipids and drug-metabolizing enzymes could be interpreted as indicating that in human liver phospholipid and cytochrome P-450 synthesis share common regulators, or that phospholipids are necessary for the maximum rate of cytochrome P-450 synthesis.	Phospholipids	41-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	269-285	
3987778-7	1985	The positive correlation between hepatic phospholipids and drug-metabolizing enzymes could be interpreted as indicating that in human liver phospholipid and cytochrome P-450 synthesis share common regulators, or that phospholipids are necessary for the maximum rate of cytochrome P-450 synthesis.	Phospholipids	41-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-173	
3987778-7	1985	The positive correlation between hepatic phospholipids and drug-metabolizing enzymes could be interpreted as indicating that in human liver phospholipid and cytochrome P-450 synthesis share common regulators, or that phospholipids are necessary for the maximum rate of cytochrome P-450 synthesis.	Phospholipids	41-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	269-285	
6508804-4	1984	In a non-membraneous reconstituted system containing NADPH cytochrome P-450 reductase, a NADPH regenerating system and phospholipids, P-450[buf] exhibited an almost complete substrate stereoselectivity for (+)-isomer 1"-hydroxylation.	Phospholipids	119-132	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-75	
6435533-1	1984	NADPH-cytochrome P-450 reductase and two purified isozymes of cytochrome P-450 have been incorporated into phospholipid vesicles by a cholate dialysis technique.	Phospholipids	107-119	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-22	
6285973-2	1982	The rate of transfer of spin-labeled phospholipid from donor vesicles of sonicated 1-acyl-2-(10-doxylstearoyl)-sn-glycero-3-phosphocholine to other vesicle was determined as a function of content of cytochrome P-450 and the phosphatidylcholine/phosphatidylethanolamine ratio in the acceptor vesicles.	Phospholipids	37-49	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	199-215	
6691964-0	1984	Lateral diffusion of cytochrome P-450 in phospholipid bilayers.	Phospholipids	41-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-37	
6412745-0	1983	Possible association of NADPH-cytochrome P-450 reductase and cytochrome P-450 in reconstituted phospholipid vesicles.	Phospholipids	95-107	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	30-46	
6407834-0	1983	Reduction of cytochrome P-450 LM2 by NADPH in reconstituted phospholipid vesicles is dependent on membrane charge.	Phospholipids	60-72	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	13-29	
6407834-1	1983	The kinetics of the reduction of cytochrome P-450 LM2 mediated by NADPH-cytochrome P-450 reductase in reconstituted phospholipid vesicles was examined.	Phospholipids	116-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-49	
6429140-1	1984	Phospholipid has been reported to be necessary for optimal catalytic activity of a number of mammalian cytochrome P-450 (P-450) systems.	Phospholipids	0-12	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-119	
109441-1	1979	The interaction between cytochrome P-450 and NADPH-cytochrome c reductase during catalysis has been investigated with a reconstituted monooxygenase system composed of the two purified enzyme components and synthetic phospholipid.	Phospholipids	216-228	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-40	
6802841-1	1982	A protein-protein association of cytochrome P-450 LM2 with NADPH-cytochrome P-450 reductase, with cytochrome b5, and with both proteins was demonstrated in reconstituted phospholipid vesicles by magnetic circular dichroism difference spectra.	Phospholipids	170-182	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-49	
6802829-7	1982	The function of cytochrome b5 was interpreted in terms of a model in which inhibition of cytochrome P-450-mediated reactions results from changes in phospholipid-protein interactions and activation occurs via facilitation of electron transfer between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane.	Phospholipids	149-161	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-105	
6264953-0	1981	Phospholipid interactions with cytochrome P-450 in reconstituted vesicles.	Phospholipids	0-12	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-47	
6086112-0	1980	[Effect of phospholipids on the activity of highly-purified liver microsome cytochrome P-450 in a reaction of aniline and naphthalene hydroxylation by hydroperoxides].	Phospholipids	11-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-92	
6086112-1	1980	The effect of different phospholipids on the functional activity of highly purified cytochrome P-450 used as a co-substrate of cumene hydroperoxide was examined.	Phospholipids	24-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-100	
7288293-2	1981	When these cytochrome P-450 species were reconstituted in phospholipid-cholesterol vesicles together with NADPH-cytochrome P-450 reductase, high cholesterol 7 alpha-hydroxylase activity was obtained in the presence of NADPH.	Phospholipids	58-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	11-27	
7236798-5	1980	Cytochrome P-450 incorporated into the artificial membranes of phosphatidyl choline and microsomal phospholipid has almost identical secondary structure as does the soluble one.	Phospholipids	99-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-16	
12746-11	1976	5. at least two different phospholipid-dependent hydrophobic zones are assumed to exist in the microsomal membrane, both coupled with cytochrome P-450.	Phospholipids	26-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	134-150	
824157-3	1976	The phospholipid facilitates the transfer of electrons from NADPH-cytochrome c reductase to cytochrome P-450 but itself is not an electron carrier.	Phospholipids	4-16	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108	
4364009-0	1974	Phospholipids of adrenal cortex mitochondria and the steroid hydroxylases: the lipid-environment of cytochrome P-450.	Phospholipids	0-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	100-116	
26627649-0	2015	Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.	Phospholipids	106-118	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	76-91