PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19686040-3 2010 Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPLs) markers of "modified-self" type that are recognized by soluble and cell-associated receptors of innate immunity, including scavenger receptors, natural (germ line-encoded) antibodies, and C-reactive protein, thus directing removal of senescent and apoptotic cells or oxidized lipoproteins. Phospholipids 77-90 C-reactive protein Homo sapiens 287-305 21301856-0 2011 Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. Phospholipids 21-33 C-reactive protein Homo sapiens 84-102 20138585-2 2010 When CRP binds to membrane phospholipids or Fc receptors, it activates the complement system. Phospholipids 27-40 C-reactive protein Homo sapiens 5-8 23449275-7 2012 C-reactive protein showed positive correlations with phosphatidylcholine, phosphatidylserine, phosphatidylinositol and total phospholipids in membranes from control subjects. Phospholipids 125-138 C-reactive protein Homo sapiens 0-18 23449275-9 2012 Furthermore, the changed relationship between membrane phospholipids and C-reactive protein, which has been shown to correlate with infectious episodes and clinical relapse, could be an indication of immune cell dysfunction in patients with multiple sclerosis. Phospholipids 55-68 C-reactive protein Homo sapiens 73-91 17207978-7 2007 Also, through antigen-antibody binding evaluation, the anti-C-reactive protein antibody immobilized on the PMBN surface worked well and it was confirmed that denaturation of the antibody on the PMBN layers was hardly occurred in spite of 60 days storage at 4 degrees C. The antibody conjugated phospholipid polymer layer with well-ordered phosphorylcholine group could be outstanding functional membrane for biomedical diagnostic devices without non-specific binding and reduction of immunologic activity of immobilized antibody. Phospholipids 294-306 C-reactive protein Homo sapiens 60-78 20011043-5 2009 To do this we evaluated: 1) the oxidation products of phospholipids (oxPAPC) in peripheral blood mononuclear cells (PBMC); 2) their role in causing PBMC reactive oxygen species (ROS) generation and changes in GSH; 3) the expression of the transcription factor NF-E2-related factor 2 (Nrf2) and of related antioxidant genes (ARE); 4) the activation of NF-kB and C-reactive protein (CRP) values. Phospholipids 54-67 C-reactive protein Homo sapiens 361-379 20011043-5 2009 To do this we evaluated: 1) the oxidation products of phospholipids (oxPAPC) in peripheral blood mononuclear cells (PBMC); 2) their role in causing PBMC reactive oxygen species (ROS) generation and changes in GSH; 3) the expression of the transcription factor NF-E2-related factor 2 (Nrf2) and of related antioxidant genes (ARE); 4) the activation of NF-kB and C-reactive protein (CRP) values. Phospholipids 54-67 C-reactive protein Homo sapiens 381-384 19778286-1 2009 BACKGROUND: C-reactive protein (CRP) is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions. Phospholipids 53-66 C-reactive protein Homo sapiens 12-30 19778286-1 2009 BACKGROUND: C-reactive protein (CRP) is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions. Phospholipids 53-66 C-reactive protein Homo sapiens 32-35 19778286-4 2009 After 30 min of incubation at 37 degrees C, the CRP-phospholipids complexes were measured by turbidimetry (660 nm/700 nm) with a Cobas 6000 analyzer (Roche). Phospholipids 52-65 C-reactive protein Homo sapiens 48-51 12011986-2 2002 Here we show that CRP exists in different structural forms in solution and on phospholipid membranes. Phospholipids 78-90 C-reactive protein Homo sapiens 18-21 16962105-3 2006 At physiological concentrations of 1-7mug/ml, CRP strongly inhibited copper-mediated oxidation of LDL and phospholipid liposomes in a concentration-dependent manner. Phospholipids 106-118 C-reactive protein Homo sapiens 46-49 16643876-5 2006 Competition experiments with different phosphatemonoesters revealed that CRP and SAP as well as part of the IgM bound to the phospholipids head groups, SAP mainly to phosphorylethanolamine, CRP to phosphorylcholine and phosphorylethanolamine and to a lesser extent to phosphorylserine, and IgM to phosphorylcholine and phosphorylserine. Phospholipids 125-138 C-reactive protein Homo sapiens 73-76 16643876-8 2006 We conclude that CRP, SAP, and part of the IgM bind to the phospholipid head groups exposed on apoptotic cells. Phospholipids 59-71 C-reactive protein Homo sapiens 17-20 15692104-0 2005 C-reactive protein and annexin A5 bind to distinct sites of negatively charged phospholipids present in oxidized low-density lipoprotein. Phospholipids 79-92 C-reactive protein Homo sapiens 0-18 15692104-1 2005 OBJECTIVE: To investigate binding of C-reactive protein (CRP) and annexin A5, 2 proteins with high affinity for negatively charged phospholipids, to oxidized low-density lipoprotein (LDL) and the consequences of these interactions for subsequent binding of oxidized LDL to monocyte/macrophage-like U937 cells. Phospholipids 131-144 C-reactive protein Homo sapiens 37-55 15692104-7 2005 CONCLUSIONS: These findings suggest that: (1) CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL; (2) CRP enhances binding of oxidized LDL to monocytic/macrophage-like cells via Fcgamma receptors; and (3) annexin A5 does not antagonize the CRP-induced enhanced binding of oxidized LDL to U937 cells. Phospholipids 142-155 C-reactive protein Homo sapiens 46-49 15692104-7 2005 CONCLUSIONS: These findings suggest that: (1) CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL; (2) CRP enhances binding of oxidized LDL to monocytic/macrophage-like cells via Fcgamma receptors; and (3) annexin A5 does not antagonize the CRP-induced enhanced binding of oxidized LDL to U937 cells. Phospholipids 142-155 C-reactive protein Homo sapiens 185-188 15692104-7 2005 CONCLUSIONS: These findings suggest that: (1) CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL; (2) CRP enhances binding of oxidized LDL to monocytic/macrophage-like cells via Fcgamma receptors; and (3) annexin A5 does not antagonize the CRP-induced enhanced binding of oxidized LDL to U937 cells. Phospholipids 142-155 C-reactive protein Homo sapiens 185-188 15078800-8 2004 CONCLUSIONS: The CRP-induced upregulation of inflammatory adhesion molecules in HUVECs was completely prevented by HDL via their oxidized phospholipid components. Phospholipids 138-150 C-reactive protein Homo sapiens 17-20 15829266-2 2005 These altered phospholipids include lysophosphotidylcholine (LPC) that is a ligand for CRP and is also antigenic for natural IgM antibodies. Phospholipids 14-27 C-reactive protein Homo sapiens 87-90 12244213-0 2002 C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Phospholipids 136-149 C-reactive protein Homo sapiens 0-18 12244213-7 2002 Reciprocally, CRP binds to PC, which can be competed for by OxLDL and OxPtC but not by native LDL, nonoxidized PtC, or by oxidized phospholipids without the PC headgroup. Phospholipids 131-144 C-reactive protein Homo sapiens 14-17 12244213-10 2002 We propose that, analogous to EO6 and scavenger receptors, CRP is a part of the innate immune response to oxidized PC-bearing phospholipids within OxLDL and on the plasma membranes of apoptotic cells. Phospholipids 126-139 C-reactive protein Homo sapiens 59-62 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phospholipids 94-107 C-reactive protein Homo sapiens 0-18 11878797-1 2002 Microparticles in the circulation activate the coagulation system and may activate the complement system via C-reactive protein upon conversion of membrane phospholipids by phospholipases. Phospholipids 156-169 C-reactive protein Homo sapiens 109-127 8906746-1 1996 C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Phospholipids 94-107 C-reactive protein Homo sapiens 20-23 7485521-2 1995 CRP was shown to detract from the ability of surfactant to rapidly adsorb to the air-water interface at a molar ratio of 0.03:1 (protein:phospholipid) (weight ratio, 0.5:1). Phospholipids 137-149 C-reactive protein Homo sapiens 0-3 34372961-8 2021 Both dietary and serum omega-3 PUFAs, mainly EPA and DPA, were negatively correlated with PCOS-related parameters, such as BMI, fasting insulin, total testosterone and high-sensitivity C-reactive protein (hs-CRP), but positively correlated with follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG). Phospholipids 23-36 C-reactive protein Homo sapiens 185-203 8144898-11 1994 CRP binding to complement-treated liposomes required phosphatidylcholine in addition to the MAC indicating that membrane phospholipids rather than the MAC proteins provide the binding sites for CRP. Phospholipids 121-134 C-reactive protein Homo sapiens 0-3 8144898-13 1994 These results support the hypothesis that CRP binding at sites of inflammation may be mediated by exposed phospholipids on damaged cell membranes. Phospholipids 106-119 C-reactive protein Homo sapiens 42-45 34372961-8 2021 Both dietary and serum omega-3 PUFAs, mainly EPA and DPA, were negatively correlated with PCOS-related parameters, such as BMI, fasting insulin, total testosterone and high-sensitivity C-reactive protein (hs-CRP), but positively correlated with follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG). Phospholipids 23-36 C-reactive protein Homo sapiens 208-211 34234508-10 2021 Conclusion: We found that metabolites in phospholipid groups had strong associations with multiple inflammatory biomarkers, especially CRP, SAA and IL-8. Phospholipids 41-53 C-reactive protein Homo sapiens 135-138 35217714-0 2022 Sex-dependent relationship of C-reactive protein levels with HDL-cholesterol and HDL-phospholipid concentrations in children. Phospholipids 85-97 C-reactive protein Homo sapiens 30-48 35217714-9 2022 In summary, high hs-CRP levels were associated with lower plasma HDL-cholesterol and HDL-phospholipid concentrations in male adolescents irrespective of adipokines, while in females, HDL-related parameters are not associated with hs-CRP concentrations. Phospholipids 89-101 C-reactive protein Homo sapiens 20-23 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phospholipids 70-83 C-reactive protein Homo sapiens 0-18 7086355-1 1982 C-reactive protein (CRP), the classical acute-phase protein, can bind phospholipids by virtue of its specific, calcium-dependent reactivity with phosphorylcholine residues. Phospholipids 70-83 C-reactive protein Homo sapiens 20-23 7086355-2 1982 However, analysis of acute-phase serum by gel filtration and by density gradient ultracentrifugation showed that the CRP was in a free, uncomplexed form, despite the coexistent presence of the various classes of serum lipoproteins, all of which contain phospholipids. Phospholipids 253-266 C-reactive protein Homo sapiens 117-120 7046574-0 1982 C-reactive protein binding specificities: artificial and natural phospholipid bilayers. Phospholipids 65-77 C-reactive protein Homo sapiens 0-18 471064-4 1979 A number of observations suggest that at least some of the biological activities of CRP depend on its interaction with phospholipids of cell membranes. Phospholipids 119-132 C-reactive protein Homo sapiens 84-87 7462634-13 1981 These findings indicate that CRP binding to membranes and subsequent C activation can occur through cationic molecules as well as phospholipids. Phospholipids 130-143 C-reactive protein Homo sapiens 29-32 29172154-0 2018 Specific binding of human C-reactive protein towards supported monolayers of binary and engineered phospholipids. Phospholipids 99-112 C-reactive protein Homo sapiens 26-44 29143304-0 2018 Inter-individual variability in phospholipid-dependent interference of C-reactive protein on activated partial thromboplastin time. Phospholipids 32-44 C-reactive protein Homo sapiens 71-89 29756266-4 2018 In addition, the self-made platelet lysate (phospholipid) was added to correct the APTT prolonged by C-reactive protein (150 mg/L) on STA-R Evolution (activator: silica) system. Phospholipids 44-56 C-reactive protein Homo sapiens 101-119 29756266-10 2018 The increasing in C-reactive protein results in a false prolongation of the APTT (activator: silica), and it is most likely that C-reactive protein interferes the coagulable factor binding of phospholipid. Phospholipids 192-204 C-reactive protein Homo sapiens 18-36 29756266-10 2018 The increasing in C-reactive protein results in a false prolongation of the APTT (activator: silica), and it is most likely that C-reactive protein interferes the coagulable factor binding of phospholipid. Phospholipids 192-204 C-reactive protein Homo sapiens 129-147 30823404-4 2019 For instance, higher levels of oxidized phospholipids on apo B-100 lipoproteins (OxPL/apoB) predicted cardiovascular events independent of traditional risk factors, C-reactive protein (hsCRP), and the Framingham Risk Score (FRS). Phospholipids 40-53 C-reactive protein Homo sapiens 165-183 29172154-2 2018 We have shown previously the calcium-independent adsorption of CRP toward 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and lysophosphatidylcholine (LPC) on supported phospholipid monolayers. Phospholipids 177-189 C-reactive protein Homo sapiens 63-66 29172154-3 2018 Here, we extended our study to other phospholipids and additives to elucidate the pattern recognition of CRP using a surface plasmon resonance biosensor. Phospholipids 37-50 C-reactive protein Homo sapiens 105-108 29172154-8 2018 Calcium-dependent CRP binding was observed only at pH 5.5 on supported monolayers of engineered phospholipids with inverted headgroups relative to POPC. Phospholipids 96-109 C-reactive protein Homo sapiens 18-21 29172154-9 2018 The complement 1q (C1q) protein recognized the active form of CRP on the supported phospholipid monolayers. Phospholipids 83-95 C-reactive protein Homo sapiens 62-65 29172154-10 2018 The discovery of CRP recognition with these phospholipids aids our understanding of the activation dynamics of CRP with phospholipid-based biomaterials when used during the acute phase. Phospholipids 44-57 C-reactive protein Homo sapiens 17-20 29172154-10 2018 The discovery of CRP recognition with these phospholipids aids our understanding of the activation dynamics of CRP with phospholipid-based biomaterials when used during the acute phase. Phospholipids 44-57 C-reactive protein Homo sapiens 111-114 29172154-10 2018 The discovery of CRP recognition with these phospholipids aids our understanding of the activation dynamics of CRP with phospholipid-based biomaterials when used during the acute phase. Phospholipids 44-56 C-reactive protein Homo sapiens 17-20 29172154-10 2018 The discovery of CRP recognition with these phospholipids aids our understanding of the activation dynamics of CRP with phospholipid-based biomaterials when used during the acute phase. Phospholipids 44-56 C-reactive protein Homo sapiens 111-114 27815167-0 2017 Calcium-independent binding of human C-reactive protein to lysophosphatidylcholine in supported planar phospholipid monolayers. Phospholipids 103-115 C-reactive protein Homo sapiens 37-55 27797973-5 2017 Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype. Phospholipids 25-38 C-reactive protein Homo sapiens 82-100 27965017-1 2017 Because of the recent discovery of multiple c-reactive protein (crp)-like genes in zebrafish (Danio rerio) with predicted heterogeneous phospholipid-binding amino acid sequences and heterogeneous transcript expression levels in viral survivors and adaptive-deficient mutants, zebrafish constitute an attractive new model for exploring the evolution of these protein"s functions, including their possible participation in fish trained immunity. Phospholipids 136-148 C-reactive protein Homo sapiens 44-62 27815167-2 2017 Here, we measured the binding kinetics of CRP to supported phospholipid monolayers deposited on an alkanethiol self-assembled monolayer on a planar gold substrate using surface plasmon resonance. Phospholipids 59-71 C-reactive protein Homo sapiens 42-45 27815167-10 2017 This paper reports the novel calcium-independent interaction of CRP to bioactive phospholipid lysophosphatidylcholine (LPC) in supported phospholipids monolayers as determined using SPR. Phospholipids 81-93 C-reactive protein Homo sapiens 64-67 27815167-10 2017 This paper reports the novel calcium-independent interaction of CRP to bioactive phospholipid lysophosphatidylcholine (LPC) in supported phospholipids monolayers as determined using SPR. Phospholipids 137-150 C-reactive protein Homo sapiens 64-67 23894199-8 2013 CRP is able to compete with phospholipid-containing liposomes for the binding to histones. Phospholipids 28-40 C-reactive protein Homo sapiens 0-3 24399680-2 2014 Since CRP is able to bind phospholipids (mainly phosphocholine) in the presence of calcium ions, we explored the possibilities of developing a high-sensitive affordable nephelometric CRP assay based on diluted soy oil emulsions. Phospholipids 26-39 C-reactive protein Homo sapiens 6-9 24399680-4 2014 After 12 min of incubation at 37 C, the CRP-phospholipid complexes were measured by nephelometry (840 nm) using a BN II nephelometer (Siemens). Phospholipids 44-56 C-reactive protein Homo sapiens 40-43 23114023-1 2012 UNLABELLED: RATIONALE: C-reactive protein (CRP) and lysophosphatidylcholine (LPC) are phosphorylcholine-(PC)-containing oxidized phospholipids (oxPLs) found in oxidized LDL (oxLDL), which trigger pro-atherogenic activities of macrophages during the process of atherosclerosis. Phospholipids 130-143 C-reactive protein Homo sapiens 24-42 23114023-1 2012 UNLABELLED: RATIONALE: C-reactive protein (CRP) and lysophosphatidylcholine (LPC) are phosphorylcholine-(PC)-containing oxidized phospholipids (oxPLs) found in oxidized LDL (oxLDL), which trigger pro-atherogenic activities of macrophages during the process of atherosclerosis. Phospholipids 130-143 C-reactive protein Homo sapiens 44-47