PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30576919-9 2019 The expression of transcription factor KLF4, a modulator of VSMC phenotype, and its downstream targets - VCAM1, CCL2, and MMP2 - were significantly reduced in the lesions of Noxa1SMC-/-/Apoe-/- versus Apoe-/- mice as well as in oxidized phospholipids treated Noxa1SMC-/- versus wild-type VSMC. Phospholipids 237-250 apolipoprotein E Mus musculus 186-190 31246210-0 2019 Eicosapentaenoic acid in the form of phospholipids exerts superior anti-atherosclerosis effects to its triglyceride form in ApoE-/- mice. Phospholipids 37-50 apolipoprotein E Mus musculus 124-128 28900205-9 2017 Together, these data suggest that ApoE proteins regulate brain phospholipid homeostasis in response to TBI and that the ApoE4 isoform is dysfunctional in this process. Phospholipids 63-75 apolipoprotein E Mus musculus 34-38 28333036-1 2017 This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer"s disease (AD). Phospholipids 85-98 apolipoprotein E Mus musculus 52-68 28333036-1 2017 This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer"s disease (AD). Phospholipids 85-98 apolipoprotein E Mus musculus 70-74 28333036-1 2017 This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer"s disease (AD). Phospholipids 100-102 apolipoprotein E Mus musculus 52-68 28333036-1 2017 This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer"s disease (AD). Phospholipids 100-102 apolipoprotein E Mus musculus 70-74 25505264-7 2015 The present findings clarify the novel roles of the LDL receptor and apoE in the clearance of S1P, a multifunctional bioactive phospholipid. Phospholipids 127-139 apolipoprotein E Mus musculus 69-73 28241068-1 2017 ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). Phospholipids 69-81 apolipoprotein E Mus musculus 103-119 28241068-1 2017 ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). Phospholipids 69-81 apolipoprotein E Mus musculus 121-125 26175148-3 2016 This effect is dependent upon lipidation of ApoE by ABCA1-mediated transfer of phospholipids and cholesterol. Phospholipids 79-92 apolipoprotein E Mus musculus 44-48 17038631-7 2007 Moreover, PLTP-/- --> apoE-/- mice have significantly higher plasma cholesterol (98%, P<0.001) and phospholipid (107%, P<0.001) than that of WT --> apoE-/- mice, thus increasing atherosclerotic lesions in the aortic arch and root (403%, P<0.001), as well as the entire aorta (298%, P<0.001). Phospholipids 105-117 apolipoprotein E Mus musculus 25-29 23601809-1 2013 Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. Phospholipids 91-104 apolipoprotein E Mus musculus 0-16 23601809-1 2013 Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. Phospholipids 91-104 apolipoprotein E Mus musculus 18-22 20543142-3 2010 Pltp KO/Apoe KO mice that were fed a coconut oil-enriched high-fat diet (COD) for 7 weeks had higher plasma free cholesterol (149%), phospholipids (15%), and sphingomyelin (54%) than Apoe KO controls. Phospholipids 133-146 apolipoprotein E Mus musculus 8-12 19956623-5 2009 Relative to apoE KO, PDZK1/apoE double KO (dKO) mice showed increased plasma lipids (33% increase in total cholesterol; 49 % increase in unesterified cholesterol; and 36% increase in phospholipids) and a 26% increase in aortic root lesions. Phospholipids 183-196 apolipoprotein E Mus musculus 27-31 18667621-1 2008 Apolipoprotein E (apoE) is a key transporter of the cholesterol and phospholipids required for membrane synthesis and nerve growth. Phospholipids 68-81 apolipoprotein E Mus musculus 0-16 18667621-1 2008 Apolipoprotein E (apoE) is a key transporter of the cholesterol and phospholipids required for membrane synthesis and nerve growth. Phospholipids 68-81 apolipoprotein E Mus musculus 18-22 20164599-2 2010 ApoE is the major apolipoprotein in the central nervous system and plays a key role in neurobiology by mediating the transport of cholesterol, phospholipids, and sulfatides. Phospholipids 143-156 apolipoprotein E Mus musculus 0-4 20164599-2 2010 ApoE is the major apolipoprotein in the central nervous system and plays a key role in neurobiology by mediating the transport of cholesterol, phospholipids, and sulfatides. Phospholipids 143-156 apolipoprotein E Mus musculus 18-32 19608875-8 2009 These oxidized phospholipid-induced Cx43 post-translational changes in VSMCs were consistent with those identified in ApoE(-/-) mice. Phospholipids 15-27 apolipoprotein E Mus musculus 118-122 19472365-8 2009 ABCA1 catalyses the ATP-dependent transport of cholesterol and phospholipids from the plasma membrane to lipid-free apolipoproteins including apoE. Phospholipids 63-76 apolipoprotein E Mus musculus 142-146 16254198-4 2006 First, adenoviral-mediated expression of apoE in dermal fibroblasts isolated from ABCA1(-/-) mice significantly increased both sterol and phospholipid efflux. Phospholipids 138-150 apolipoprotein E Mus musculus 41-45 11893784-8 2002 ApoE(-/-) and LDLr(-/-) mice, but not controls, had elevated plasma bioactive oxidized phospholipids on the Western diet. Phospholipids 87-100 apolipoprotein E Mus musculus 0-4 15890642-7 2005 The mutant mouse apoE more rapidly remodeled phospholipid than T61R mouse apoE, which supports the hypothesis that a destabilized conformation promotes apoE4 lipid binding. Phospholipids 45-57 apolipoprotein E Mus musculus 17-21 15364338-0 2004 Rapid reversal of endothelial dysfunction in hypercholesterolemic apolipoprotein E-null mice by recombinant apolipoprotein A-I(Milano)-phospholipid complex. Phospholipids 135-147 apolipoprotein E Mus musculus 66-82 11893784-2 2002 ApoE(-/-) mice had reduced (28%) LCAT activity and elevated lysophosphatidylcholine and bioactive oxidized phospholipids (1-palmitoyl-2-oxovaleryl-sn-glycero-3-phosphocholine and 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine) compared with controls on the chow diet. Phospholipids 107-120 apolipoprotein E Mus musculus 0-4 14504179-0 2003 Oral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis in apolipoprotein E-null mice. Phospholipids 15-27 apolipoprotein E Mus musculus 171-187 12093886-8 2002 Lipid analysis of HDL particles from BAC(+)ApoE(-/-) mice revealed an increase in phospholipid levels, which was correlated significantly with their ability to enhance cholesterol efflux. Phospholipids 82-94 apolipoprotein E Mus musculus 43-47 11893773-4 2002 We show that in apoE-expressing cells, a 4-fold increase in SR-BI expression leads to reduction of sterol and phospholipid efflux. Phospholipids 110-122 apolipoprotein E Mus musculus 16-20 11902115-3 2002 Apolipoprotein E (apoE) is a major apolipoprotein in the CNS, mediating the transport of cholesterol, phospholipids and their fatty acids, particularly in reparative mechanisms during neuronal injury. Phospholipids 102-115 apolipoprotein E Mus musculus 0-16 11719520-3 2002 ApoE-/- LCAT-/- mice fed the atherogenic diet, compared with apoE-/- mice, had higher concentrations of plasma FC, EC, apoB lipoprotein cholesterol, and phospholipid, and significantly more aortic FC (149 +/- 62 versus 109 +/- 33 mg/g) and EC (101 +/- 23 versus 69 +/- 20 mg/g) than did the apoE-/- mice. Phospholipids 153-165 apolipoprotein E Mus musculus 0-4 11902115-4 2002 This study was performed to determine whether deficiency in the apoE gene contributes to an alteration of the phospholipids in synaptic plasma membranes. Phospholipids 110-123 apolipoprotein E Mus musculus 64-68 11902115-3 2002 Apolipoprotein E (apoE) is a major apolipoprotein in the CNS, mediating the transport of cholesterol, phospholipids and their fatty acids, particularly in reparative mechanisms during neuronal injury. Phospholipids 102-115 apolipoprotein E Mus musculus 18-22 9884341-8 1999 These data suggest that oxidized phospholipid epitopes, present either as lipids or as lipid-protein adducts, represent one class of ligands involved in the recognition of OxLDL by macrophages, and that apoE-deficient mice have IgM autoantibodies that can bind to these neoepitopes and inhibit OxLDL uptake. Phospholipids 33-45 apolipoprotein E Mus musculus 203-207 11742879-3 2001 Macrophages are relatively unique among cells because they express apoprotein E (apoE) as a major protein product, and this endogenous expression of apoE increases sterol and phospholipid efflux from macrophages. Phospholipids 175-187 apolipoprotein E Mus musculus 67-79 11742879-3 2001 Macrophages are relatively unique among cells because they express apoprotein E (apoE) as a major protein product, and this endogenous expression of apoE increases sterol and phospholipid efflux from macrophages. Phospholipids 175-187 apolipoprotein E Mus musculus 81-85 11742879-3 2001 Macrophages are relatively unique among cells because they express apoprotein E (apoE) as a major protein product, and this endogenous expression of apoE increases sterol and phospholipid efflux from macrophages. Phospholipids 175-187 apolipoprotein E Mus musculus 149-153 10533050-3 1999 In the present study we examined the possibility that the neuronal derangements of apoE-deficient mice are related to impairments in their phospholipid metabolism. Phospholipids 139-151 apolipoprotein E Mus musculus 83-87 10533050-10 1999 These findings show that apoE deficiency results in specific and intracellular compartment-dependent changes in phospholipid metabolism, which may play an important role in mediating the neuronal effects of apoE. Phospholipids 112-124 apolipoprotein E Mus musculus 25-29 10533050-10 1999 These findings show that apoE deficiency results in specific and intracellular compartment-dependent changes in phospholipid metabolism, which may play an important role in mediating the neuronal effects of apoE. Phospholipids 112-124 apolipoprotein E Mus musculus 207-211 10101254-3 1999 It was found that brain phospholipid levels in apolipoprotein E deficient mice are lower than those of the controls (55+/-15% of control, P<0. Phospholipids 24-36 apolipoprotein E Mus musculus 47-63 34099706-0 2021 Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer"s disease. Phospholipids 0-13 apolipoprotein E Mus musculus 17-21 35321401-1 2022 Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. Phospholipids 99-112 apolipoprotein E Mus musculus 6-22 35321401-1 2022 Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. Phospholipids 99-112 apolipoprotein E Mus musculus 24-28 33691599-6 2021 There was significantly higher abundance of some lipid metabolites in the plasma of ovariectomized HFD-fed ApoE-/- mice than in non-ovariectomized ones, including cholesterol esters, triglycerides, phospholipids, and other types of lipids (free fatty acids, acylcarnitine, sphingomyelins, and ceramides). Phospholipids 198-211 apolipoprotein E Mus musculus 107-111 32949768-4 2020 The age-related decrease in the phospholipid content was more pronounced in ApoE/LDLR-/- mice. Phospholipids 32-44 apolipoprotein E Mus musculus 76-80