PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17709913-11 2007 The antioxidant normalized the hepatic handling of the Mrp2 substrates, rose bengal, and dinitrophenyl-S-glutathione, which was causally associated with restoration of Mrp2 expression. S-(2,4-dinitrophenyl)glutathione 89-116 ATP binding cassette subfamily C member 2 Rattus norvegicus 168-172 22925079-7 2013 P-GP and MRP2 function in brain were determined using the brain-to-plasma ratios of corresponding substrates (rhodamine 123 and vincristine for P-GP; sulfobromophthalein and dinitrophenyl-S-glutathione for MRP2). S-(2,4-dinitrophenyl)glutathione 174-201 ATP binding cassette subfamily C member 2 Rattus norvegicus 206-210 22453052-1 2012 The ability of the liver, small intestine, and kidney to synthesize and subsequently eliminate dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), was assessed in rats treated with glucagon-like peptide 2 (GLP-2, 12 mug/100 g b.wt. S-(2,4-dinitrophenyl)glutathione 95-122 ATP binding cassette subfamily C member 2 Rattus norvegicus 149-190 22453052-1 2012 The ability of the liver, small intestine, and kidney to synthesize and subsequently eliminate dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), was assessed in rats treated with glucagon-like peptide 2 (GLP-2, 12 mug/100 g b.wt. S-(2,4-dinitrophenyl)glutathione 95-122 ATP binding cassette subfamily C member 2 Rattus norvegicus 192-196 19766108-5 2009 The serosal to mucosal transport of dinitrophenyl S-glutathione, a model substrate of Mrp2 was evaluated in jejunal sac model. S-(2,4-dinitrophenyl)glutathione 36-63 ATP binding cassette subfamily C member 2 Rattus norvegicus 86-90 19782883-8 2009 We concluded that MRP2 transporter is related to glucose stimulated DNPSG secretion. S-(2,4-dinitrophenyl)glutathione 68-73 ATP binding cassette subfamily C member 2 Rattus norvegicus 18-22 19299525-3 2009 Mrp2 transport activity toward dinitrophenyl-S-glutathione (DNP-SG) was assessed in vitro in intestinal sacs. S-(2,4-dinitrophenyl)glutathione 31-58 ATP binding cassette subfamily C member 2 Rattus norvegicus 0-4 15590889-0 2005 Involvement of Mrp2 in hepatic and intestinal disposition of dinitrophenyl-S-glutathione in partially hepatectomized rats. S-(2,4-dinitrophenyl)glutathione 61-88 ATP binding cassette subfamily C member 2 Rattus norvegicus 15-19 16139386-4 2005 Impaired bile salt-independent bile flow in obese rats was associated with a 50% reduction of biliary secretion of the Mrp 2 model-substrates glutathione disulfide and S-(2,4-dinitrophenyl)glutathione. S-(2,4-dinitrophenyl)glutathione 168-200 ATP binding cassette subfamily C member 2 Rattus norvegicus 119-124 15590889-1 2005 The ability of the liver and small intestine for secretion of dinitrophenyl-S-glutathione (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), into bile and lumen, respectively, as well as expression of Mrp2 in both tissues, were assessed in 70-75% hepatectomized rats. S-(2,4-dinitrophenyl)glutathione 62-89 ATP binding cassette subfamily C member 2 Rattus norvegicus 159-163 15276087-4 2004 In vivo biliary excretion of dinitrophenyl-S-glutathione, a well known Mrp2 substrate, was slightly but significantly increased by APAP, agreeing well with upregulation of the transporter. S-(2,4-dinitrophenyl)glutathione 29-56 ATP binding cassette subfamily C member 2 Rattus norvegicus 71-75 15652244-12 2005 Enhanced activity and expression of Mrp2 was confirmed by analyzing the excretion rate of dinitrophenyl S-glutathione, an exogenous substrate of Mrp2, in isolated hepatocytes and by immunofluorescence microscopy, respectively. S-(2,4-dinitrophenyl)glutathione 90-117 ATP binding cassette subfamily C member 2 Rattus norvegicus 36-40 15652244-12 2005 Enhanced activity and expression of Mrp2 was confirmed by analyzing the excretion rate of dinitrophenyl S-glutathione, an exogenous substrate of Mrp2, in isolated hepatocytes and by immunofluorescence microscopy, respectively. S-(2,4-dinitrophenyl)glutathione 90-117 ATP binding cassette subfamily C member 2 Rattus norvegicus 145-149 14976346-7 2004 Expression of multidrug resistance-associated protein 2 (Mrp2), the main, multispecific transporter involved in the canalicular excretion of organic anions, was also decreased (-40%), which was associated with a significant decrease in the cumulative biliary excretion of the Mrp2 substrate, dinitrophenyl-S-glutathione (-50%). S-(2,4-dinitrophenyl)glutathione 292-319 ATP binding cassette subfamily C member 2 Rattus norvegicus 14-55 14976346-7 2004 Expression of multidrug resistance-associated protein 2 (Mrp2), the main, multispecific transporter involved in the canalicular excretion of organic anions, was also decreased (-40%), which was associated with a significant decrease in the cumulative biliary excretion of the Mrp2 substrate, dinitrophenyl-S-glutathione (-50%). S-(2,4-dinitrophenyl)glutathione 292-319 ATP binding cassette subfamily C member 2 Rattus norvegicus 57-61 7768511-5 1995 The appearance of intracellular cMOAT activity coincides with the disappearance of 70% of cMOAT activity from the plasma membrane as measured by the transport activity of the cells for the organic anion dinitrophenyl-glutathione (GS-DNP). S-(2,4-dinitrophenyl)glutathione 230-236 ATP binding cassette subfamily C member 2 Rattus norvegicus 32-37 9756510-5 1998 This ATP-dependent uptake was saturable with a Michaelis constant (Km) value of 126 microM, which was comparable with its inhibitor constant (Ki) value of 121 microM for the ATP-dependent uptake of a typical cMOAT substrate, 2,4-dinitrophenyl-S-glutathione (DNP-SG). S-(2,4-dinitrophenyl)glutathione 258-264 ATP binding cassette subfamily C member 2 Rattus norvegicus 208-213 12029626-6 2002 The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval. S-(2,4-dinitrophenyl)glutathione 69-96 ATP binding cassette subfamily C member 2 Rattus norvegicus 53-57 12029626-6 2002 The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval. S-(2,4-dinitrophenyl)glutathione 69-96 ATP binding cassette subfamily C member 2 Rattus norvegicus 151-155 12029626-6 2002 The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval. S-(2,4-dinitrophenyl)glutathione 98-104 ATP binding cassette subfamily C member 2 Rattus norvegicus 53-57 12029626-6 2002 The biliary concentration and excretion of the model Mrp2 substrate, dinitrophenyl-S-glutathione (DNP-SG), was impaired in parallel with the extent of Mrp2 retrieval. S-(2,4-dinitrophenyl)glutathione 98-104 ATP binding cassette subfamily C member 2 Rattus norvegicus 151-155 10101137-5 1999 Similarly, there was also much lower inhibition of the ATP-dependent uptake of S-(2,4-dinitrophenyl)-glutathione, a substrate of cMOAT, by the above compounds. S-(2,4-dinitrophenyl)glutathione 79-112 ATP binding cassette subfamily C member 2 Rattus norvegicus 129-134 9321514-9 1997 ATP-dependent uptake of 2, 4-dinitrophenyl glutathione, a typical substrate for the canalicular multispecific organic anion transporter (cMOAT), was inhibited by pravastatin in a concentration-dependent manner and the resultant inhibitory constant of pravastatin (170 microM) was comparable with the KM value of ATP-dependent pravastatin uptake itself. S-(2,4-dinitrophenyl)glutathione 24-54 ATP binding cassette subfamily C member 2 Rattus norvegicus 84-135 9321514-9 1997 ATP-dependent uptake of 2, 4-dinitrophenyl glutathione, a typical substrate for the canalicular multispecific organic anion transporter (cMOAT), was inhibited by pravastatin in a concentration-dependent manner and the resultant inhibitory constant of pravastatin (170 microM) was comparable with the KM value of ATP-dependent pravastatin uptake itself. S-(2,4-dinitrophenyl)glutathione 24-54 ATP binding cassette subfamily C member 2 Rattus norvegicus 137-142 7768511-5 1995 The appearance of intracellular cMOAT activity coincides with the disappearance of 70% of cMOAT activity from the plasma membrane as measured by the transport activity of the cells for the organic anion dinitrophenyl-glutathione (GS-DNP). S-(2,4-dinitrophenyl)glutathione 230-236 ATP binding cassette subfamily C member 2 Rattus norvegicus 90-95