PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16300803-5	2006	Interestingly, however, acute LiCl treatment significantly reduced the phosphorylation of cAMP related element binding protein (CREB), a major intracellular target of trkB, in the HC.	Lithium Chloride	30-34	cAMP responsive element binding protein 1	Mus musculus	90-126	
25451297-0	2015	Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways.	Lithium Chloride	0-16	cAMP responsive element binding protein 1	Mus musculus	100-104	
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium Chloride	259-275	cAMP responsive element binding protein 1	Mus musculus	21-50	
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium Chloride	277-281	cAMP responsive element binding protein 1	Mus musculus	21-50	
17043650-6	2007	LiCl, an inhibitor of GSK3beta, abolished inhibitory effect of PTEN on cyclin D2 expression, and TCF members could directly bind to the promoter of cyclin D2 and regulate its transcription in a CREB-dependent manner.	Lithium Chloride	0-4	cAMP responsive element binding protein 1	Mus musculus	194-198	
25451297-9	2015	Therefore, the use of LiCl to balance between beta-catenin and CREB effectors could be considered as an efficient remyelinating strategy.	Lithium Chloride	22-26	cAMP responsive element binding protein 1	Mus musculus	63-67	
16300803-5	2006	Interestingly, however, acute LiCl treatment significantly reduced the phosphorylation of cAMP related element binding protein (CREB), a major intracellular target of trkB, in the HC.	Lithium Chloride	30-34	cAMP responsive element binding protein 1	Mus musculus	128-132	
16300803-9	2006	The activation of CREB is, however, significantly reduced in the HC after acute LiCl treatment.	Lithium Chloride	80-84	cAMP responsive element binding protein 1	Mus musculus	18-22	
28366776-0	2017	Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.	Lithium Chloride	141-157	cAMP responsive element binding protein 1	Mus musculus	28-32	
28366776-5	2017	Moreover, the combined application of AST and LiCl had synergistic therapeutic effects compared to LiCl and AST treatment alone, the expression of p-GSK3beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application.	Lithium Chloride	46-50	cAMP responsive element binding protein 1	Mus musculus	161-165