PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16870161-1	2006	In cultured bovine adrenal chromaffin cells, 12-h treatment with 1-20 mM LiCl, an inhibitor of glycogen synthase kinase-3 (GSK-3), increased Ser(9) phosphorylation of GSK-3beta by approximately 44%, while decreasing insulin receptor substrate-1 (IRS-1) and IRS-2 protein levels by approximately 38 and approximately 62% in a concentration-dependent manner.	Lithium Chloride	73-77	insulin receptor substrate 2	Bos taurus	257-262	
16870161-4	2006	Either clasto-lactacystin beta-lactone or lactacystin (an inhibitor of proteasome) prevented LiCl- or SB216763-induced decreases of IRS-1 and IRS-2 levels by approximately 100 and approximately 69%, respectively.	Lithium Chloride	93-97	insulin receptor substrate 2	Bos taurus	142-147	
16870161-6	2006	LiCl or SB216763 lowered IRS-2 mRNA level, with no effect on IRS-1 mRNA level.	Lithium Chloride	0-4	insulin receptor substrate 2	Bos taurus	25-30