PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 interleukin 1 beta Homo sapiens 45-53 24470226-8 2014 CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways. Lithium Chloride 12-16 interleukin 1 beta Homo sapiens 147-155 17988365-6 2007 In vitro exposure of monocytes to LiCl did not have the same effects as lithium treatment: the procedure decreased IL-1beta production and had minimal effects on IL-6 production. Lithium Chloride 34-38 interleukin 1 beta Homo sapiens 115-123 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 14-30 interleukin 1 beta Homo sapiens 247-264 26593276-5 2016 We found that lithium chloride (LiCl), a widely used GSK3 inhibitor and the mainstay treatment for bipolar disorder, reinforced the LPS adaptive response by enhancing both downregulation of pro-inflammatory genes (inducible nitric oxide synthase, interleukin 1beta, interleukin 6, tumor necrosis factor alpha), and upregulation of genes typically associated to anti-inflammatory functions (interleukin 10 and MRC1). Lithium Chloride 32-36 interleukin 1 beta Homo sapiens 247-264 25746333-9 2015 We also found that lower viral replication after LiCl treatment was associated with the reduced mRNA levels of pro-inflammatory IL-8, IL-6, IL-1 beta, tumor necrosis factor alpha and decreased NF-kappaB nuclear translocation. Lithium Chloride 49-53 interleukin 1 beta Homo sapiens 140-149 31573051-13 2019 In addition, the results demonstrated that IL-21 treatment reduced the expression levels of proteins associated with the Wnt/beta-catenin signaling, whereas activation of Wnt/beta-catenin signaling with the LiCl agonist upregulated PD-L1, IL-1beta and TNF-alpha expression. Lithium Chloride 207-211 interleukin 1 beta Homo sapiens 239-247 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 interleukin 1 beta Homo sapiens 51-59