PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17883398-2 2007 LiCl increased inhibitory Ser9-phosphorylation of GSK-3beta at 6 h, decreasing (125)I-insulin binding at 24 h. SB216763-induced (125)I-insulin binding reduction (IC(50) = 3 micromol/L) was preceded by beta-catenin level increase by SB216763 (EC(50) = 11 micromol/L), a hallmark of GSK-3 inhibition. Lithium Chloride 0-4 glycogen synthase kinase 3 beta Bos taurus 50-59 26200352-7 2015 Inhibition of GSK3alpha and GSK3beta with LiCl or SB216763 induced an increase in IL-12p40 mRNA and protein. Lithium Chloride 42-46 glycogen synthase kinase 3 beta Bos taurus 28-36 19470708-8 2009 Administration of inhibitors of GSK3 activity (lithium chloride or 2"Z,3"E -6-bromoindirubin-3"-oxime) rapidly increased phospho-Ser(9)-GSK3B, and led to transient decrease of phospho-MAPK3/MAPK1 and to durable enhancing of phospho-MAPK14 in granulosa primary cell culture. Lithium Chloride 47-63 glycogen synthase kinase 3 beta Bos taurus 136-141 18395711-4 2008 LiCl- or SB216763-induced Akt1 decrease, as well as increases of Ser9-phosphorylated glycogen synthase kinase-3beta and beta-catenin were restored to the control levels of nontreated cells after the washout of LiCl (20 mM for 24 h)- or SB216763 (30 microM for 24 h)-treated cells. Lithium Chloride 210-214 glycogen synthase kinase 3 beta Bos taurus 85-115 16870161-1 2006 In cultured bovine adrenal chromaffin cells, 12-h treatment with 1-20 mM LiCl, an inhibitor of glycogen synthase kinase-3 (GSK-3), increased Ser(9) phosphorylation of GSK-3beta by approximately 44%, while decreasing insulin receptor substrate-1 (IRS-1) and IRS-2 protein levels by approximately 38 and approximately 62% in a concentration-dependent manner. Lithium Chloride 73-77 glycogen synthase kinase 3 beta Bos taurus 167-176