PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26108692-0 2015 Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. Lithium Chloride 0-16 midkine Mus musculus 84-87 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 109-125 midkine Mus musculus 14-17 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 127-131 midkine Mus musculus 14-17 26108692-7 2015 In this work, we demonstrate that LiCl, a well-tolerated agent in humans, has antileukemic activity in APL and that it has the potential to restore RA-induced transcriptional activation and differentiation in RA-resistant APL cells in an MEK/ERK-dependent manner. Lithium Chloride 34-38 midkine Mus musculus 238-241 23904208-0 2014 Lithium chloride induces TNFalpha in mouse macrophages via MEK-ERK-dependent pathway. Lithium Chloride 0-16 midkine Mus musculus 59-62