PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26108692-0 2015 Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent. Lithium Chloride 0-16 mitogen-activated protein kinase 1 Mus musculus 88-91 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 109-125 mitogen-activated protein kinase 1 Mus musculus 18-21 26108692-2 2015 To target the MEK/ERK pathway, we identified glycogen synthase kinase-3beta (GSK-3beta) inhibitors including lithium chloride (LiCl) as activators of this pathway in APL cells. Lithium Chloride 127-131 mitogen-activated protein kinase 1 Mus musculus 18-21 26108692-7 2015 In this work, we demonstrate that LiCl, a well-tolerated agent in humans, has antileukemic activity in APL and that it has the potential to restore RA-induced transcriptional activation and differentiation in RA-resistant APL cells in an MEK/ERK-dependent manner. Lithium Chloride 34-38 mitogen-activated protein kinase 1 Mus musculus 242-245 23904208-0 2014 Lithium chloride induces TNFalpha in mouse macrophages via MEK-ERK-dependent pathway. Lithium Chloride 0-16 mitogen-activated protein kinase 1 Mus musculus 63-66 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. Lithium Chloride 259-275 mitogen-activated protein kinase 1 Mus musculus 67-104 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. Lithium Chloride 259-275 mitogen-activated protein kinase 1 Mus musculus 106-109 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. Lithium Chloride 277-281 mitogen-activated protein kinase 1 Mus musculus 67-104 23324999-4 2013 Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP. Lithium Chloride 277-281 mitogen-activated protein kinase 1 Mus musculus 106-109