PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34656851-2	2021	Investigations of LiCl-induced signaling have focused mainly on extracellular signal regulated kinase 1/2 (ERK1/2) and glycogen synthase kinase 3 (GSK-3).	Lithium Chloride	18-22	mitogen-activated protein kinase 3	Homo sapiens	107-113	
28867214-0	2018	Lithium chloride inhibits StAR and progesterone production through GSK-3beta and ERK1/2 signaling pathways in human granulosa-lutein cells.	Lithium Chloride	0-16	mitogen-activated protein kinase 3	Homo sapiens	81-87	
28867214-6	2018	Additionally, LiCl induced the phosphorylation of GSK-3beta and ERK1/2 but not AKT or CREB.	Lithium Chloride	14-18	mitogen-activated protein kinase 3	Homo sapiens	64-70	
28867214-7	2018	Knockdown of endogenous GSK-3beta or inhibition of ERK1/2 partially reversed LiCl-induced down-regulation of StAR.	Lithium Chloride	77-81	mitogen-activated protein kinase 3	Homo sapiens	51-57	
28867214-8	2018	Furthermore, by using dual inhibition approaches, the results showed that both GSK-3beta and ERK1/2 signaling mediated the regulatory effect of LiCl on StAR expression.	Lithium Chloride	144-148	mitogen-activated protein kinase 3	Homo sapiens	93-99	
28911173-6	2017	Using dual inhibition approaches, our results show that LiCl initiates the hGL cellular action by inhibiting the activity of glycogen synthase kinase-3beta [GSK-3beta (phosphorylation of GSK-3beta)] and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), but not by affecting protein kinase B or cAMP response element binding protein signaling.	Lithium Chloride	56-60	mitogen-activated protein kinase 3	Homo sapiens	260-266