PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1651781-2 1991 This study shows the in vitro effect of LiCl on the TNF-induced or interleukin 1 (IL-1)-induced expression of IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, IL-2, and the IL-2 receptor-alpha (IL-2R alpha). Lithium Chloride 40-44 interleukin 1 complex Mus musculus 67-86 1651781-7 1991 However, LiCl potentiated the IL-1-induced synthesis of IL-6, GM-CSF, IL-3, and IL-2 in PC60 murine T-cell hybridoma cells. Lithium Chloride 9-13 interleukin 1 complex Mus musculus 30-34 1651781-10 1991 IL-2R alpha expression was likewise considerably enhanced by IL-1 + LiCl treatment, as compared with treatment with IL-1 alone. Lithium Chloride 68-72 interleukin 1 complex Mus musculus 116-120 1651781-11 1991 The effects of LiCl on the TNF-induced and the IL-1-induced gene expression seem to be independent of the protein kinase A and C pathways. Lithium Chloride 15-19 interleukin 1 complex Mus musculus 47-51 1651781-12 1991 These results show that LiCl can modulate both TNF-mediated cytotoxicity and TNF-induced and IL-1-induced cytokine expression, suggesting that Li+ acts early in the TNF-signaling pathway, but at a step shared with the IL-1-signaling pathway. Lithium Chloride 24-28 interleukin 1 complex Mus musculus 93-97 1651781-12 1991 These results show that LiCl can modulate both TNF-mediated cytotoxicity and TNF-induced and IL-1-induced cytokine expression, suggesting that Li+ acts early in the TNF-signaling pathway, but at a step shared with the IL-1-signaling pathway. Lithium Chloride 24-28 interleukin 1 complex Mus musculus 218-222