PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25206585-5 2013 The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3beta inhibitor, LiCl, creased before intervention with lipopolysaccharide, but increased after treatment with the AKT hibitor, LY294002. Lithium Chloride 135-139 BCL2 associated X, apoptosis regulator Homo sapiens 47-50 29773200-0 2018 Lithium chloride attenuates mitomycin C induced necrotic cell death in MDA-MB-231 breast cancer cells via HMGB1 and Bax signaling. Lithium Chloride 0-16 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 29773200-8 2018 LiCl combined with mitomycin C significantly down-regulated HMGB1, MMP9 and Bcl-2 gene expression but significantly increased the level of Bax protein. Lithium Chloride 0-4 BCL2 associated X, apoptosis regulator Homo sapiens 139-142 23054864-7 2012 The results showed breast cancer cells respond in a diverse manner to LiCl, i.e., at lower concentrations (1, 5, and 10 mM), LiCl induces cell survival by inhibiting apoptosis through regulation of GSK-3beta, caspase-2, Bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (Akt, beta-catenin, Bcl-2, and cyclin D1). Lithium Chloride 125-129 BCL2 associated X, apoptosis regulator Homo sapiens 220-223 11520785-8 2001 Furthermore, lithium chloride, but not caspase inhibition, prevented the appearance of the conformational form of Bax associated with apoptosis induction. Lithium Chloride 13-29 BCL2 associated X, apoptosis regulator Homo sapiens 114-117 34883226-3 2022 Through cell culture, virus infection, and RT-qPCR, we found that LiCl could down-regulate the apoptosis-related genes Caspase-3 and Bax, up-regulate Bcl-2, and down-regulate the inflammatory-related genes (NF-kappaB, NLRP3, TNF-alpha, and IL-1beta) via inhibiting virus replication. Lithium Chloride 66-70 BCL2 associated X, apoptosis regulator Homo sapiens 133-136 10037682-3 1999 Long term, but not acute, treatment of cultured cerebellar granule cells with LiCl induces a concentration-dependent decrease in mRNA and protein levels of proapoptotic p53 and Bax; conversely, mRNA and protein levels of cytoprotective Bcl-2 are remarkably increased. Lithium Chloride 78-82 BCL2 associated X, apoptosis regulator Homo sapiens 177-180 10037682-6 1999 Pretreatment with LiCl for 7 days prevents glutamate-induced increase in p53 and Bax expression and maintains Bcl-2 in an elevated state. Lithium Chloride 18-22 BCL2 associated X, apoptosis regulator Homo sapiens 81-84