PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11755929-4	2002	Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs.	nicotine 1-N-oxide	122-125	interleukin 1 beta	Rattus norvegicus	5-13	
17920716-3	2008	In the mPFC, central administration of IL-1beta into the mPFC resulted in dose-dependent increases in levels of both NOx(-) and 2,3-DHBA.	nicotine 1-N-oxide	117-121	interleukin 1 beta	Rattus norvegicus	39-47	
17920716-4	2008	In contrast, peripheral administration of IL-1beta significantly increased NOx(-) levels but not 2,3-DHBA levels.	nicotine 1-N-oxide	75-78	interleukin 1 beta	Rattus norvegicus	42-50	
10086983-3	1999	In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase.	nicotine 1-N-oxide	121-124	interleukin 1 beta	Rattus norvegicus	14-22	
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	nicotine 1-N-oxide	17-20	interleukin 1 beta	Rattus norvegicus	47-69	
10218970-4	1999	Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively.	nicotine 1-N-oxide	103-106	interleukin 1 beta	Rattus norvegicus	5-27	
10758978-5	2000	RESULTS: Treatment with IL-1beta (10 ng/ml) increased myocyte production of NOx in a time-dependent manner.	nicotine 1-N-oxide	76-79	interleukin 1 beta	Rattus norvegicus	24-32	
10086983-6	1999	After bilateral adrenalectomy, IL-1beta induced a smaller pressor response, but a larger increase in plasma NOx; dexamethasone reversed these changes.	nicotine 1-N-oxide	108-111	interleukin 1 beta	Rattus norvegicus	31-39	
7528993-2	1994	Among several cytokines and bacterial lipopolysaccharide tested, IL-1 beta most effectively stimulated NOx production.	nicotine 1-N-oxide	103-106	interleukin 1 beta	Rattus norvegicus	65-74	
7528993-3	1994	IL-1 beta dose and time dependently stimulated NOx production.	nicotine 1-N-oxide	47-50	interleukin 1 beta	Rattus norvegicus	0-9	
7528993-5	1994	Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein.	nicotine 1-N-oxide	86-89	interleukin 1 beta	Rattus norvegicus	68-77	
7528993-6	1994	TGF-beta dose dependently inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression.	nicotine 1-N-oxide	58-61	interleukin 1 beta	Rattus norvegicus	40-49	
7517798-10	1994	Dexamethasone inhibited the IL-1 beta-induced NOx production as well as iNOS mRNA expression.	nicotine 1-N-oxide	46-49	interleukin 1 beta	Rattus norvegicus	28-37	
7517798-4	1994	IL-1 beta dose-dependently (0.1 to 10 ng/mL) stimulated NOx production as a function of time (6 to 48 hours).	nicotine 1-N-oxide	56-59	interleukin 1 beta	Rattus norvegicus	0-9	
7517798-9	1994	NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine.	nicotine 1-N-oxide	86-89	interleukin 1 beta	Rattus norvegicus	68-77	
7517798-11	1994	Cycloheximide and actinomycin D completely inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression.	nicotine 1-N-oxide	75-78	interleukin 1 beta	Rattus norvegicus	57-66