PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27313009-6 2016 Moreover, Nox-dependent ROS generation led to phosphorylation of ERK1/2, p38, and JNK, which then activated the downstream molecules NF-kappaB and AP-1, respectively. nicotine 1-N-oxide 10-13 nuclear factor kappa B subunit 1 Homo sapiens 133-142 20204677-6 2010 Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor. nicotine 1-N-oxide 81-85 nuclear factor kappa B subunit 1 Homo sapiens 104-112