PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25200604-0	2014	A sesquiterpene lactone from a medicinal herb inhibits proinflammatory activity of TNF-alpha by inhibiting ubiquitin-conjugating enzyme UbcH5.	sesquiterpene lactone	2-23	tumor necrosis factor	Homo sapiens	83-92	
32738593-0	2020	Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1beta and TNF-alpha.	sesquiterpene lactone	0-21	tumor necrosis factor	Homo sapiens	163-172	
15209353-4	2004	Here, we demonstrate that dehydrocostus lactone (DL), the major sesquiterpene lactone isolated from the roots of Saussurea lappa, inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that DL renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities.	sesquiterpene lactone	64-85	tumor necrosis factor	Homo sapiens	174-183	
10553091-3	1999	This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the TNF-alpha-induced induction of I kappa B kinase (IKK) and IKK beta, without affecting the activation of p38 and c-Jun N-terminal kinase.	sesquiterpene lactone	26-47	tumor necrosis factor	Homo sapiens	127-136	
10553091-7	1999	Therefore, this sesquiterpene lactone could serve as a lead compound for the development of antiinflammatory remedies and is suitable as a molecular tool, allowing the dissection of TNF-alpha-derived signaling pathways leading to the activation of NF-kappa B, c-Jun N-terminal kinase, and p38.	sesquiterpene lactone	16-37	tumor necrosis factor	Homo sapiens	182-191