PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34332075-0	2021	Eicosapentaenoic acid membrane incorporation stimulates ABCA1-mediated cholesterol efflux from human THP-1 macrophages.	Eicosapentaenoic Acid	0-21	ATP binding cassette subfamily A member 1	Homo sapiens	56-61	
26791180-5	2016	RESULTS: On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (beta = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (beta = 3.87 mg/dL, P = 5.62 x 10(21)).	Eicosapentaenoic Acid	265-286	ATP binding cassette subfamily A member 1	Homo sapiens	151-192	
26791180-5	2016	RESULTS: On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (beta = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (beta = 3.87 mg/dL, P = 5.62 x 10(21)).	Eicosapentaenoic Acid	265-286	ATP binding cassette subfamily A member 1	Homo sapiens	194-199	
26791180-5	2016	RESULTS: On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (beta = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (beta = 3.87 mg/dL, P = 5.62 x 10(21)).	Eicosapentaenoic Acid	288-291	ATP binding cassette subfamily A member 1	Homo sapiens	151-192	
26791180-5	2016	RESULTS: On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (beta = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (beta = 3.87 mg/dL, P = 5.62 x 10(21)).	Eicosapentaenoic Acid	288-291	ATP binding cassette subfamily A member 1	Homo sapiens	194-199	
19070858-0	2009	Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells.	Eicosapentaenoic Acid	0-21	ATP binding cassette subfamily A member 1	Homo sapiens	30-35	
19070858-0	2009	Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells.	Eicosapentaenoic Acid	0-21	ATP binding cassette subfamily A member 1	Homo sapiens	71-76	
34332075-5	2021	EPA 70 muM, but not AA 50 muM or DHA 15 muM, increased ABCA1-mediated cholesterol efflux to apolipoprotein (apo) AI by 28% without altering aqueous diffusion.	Eicosapentaenoic Acid	0-3	ATP binding cassette subfamily A member 1	Homo sapiens	55-60	
34332075-13	2021	In conclusion, EPA membrane incorporation increased ABCA1 functionality in cholesterol-normal human THP-1 macrophages, likely through a combination of different mechanisms.	Eicosapentaenoic Acid	15-18	ATP binding cassette subfamily A member 1	Homo sapiens	52-57	
29574773-6	2018	While we found no changes in the mRNA expression of ECM components, EPA and DHA treatment reduced levels of ABCG1, ABCA1, and AKAP13 in both cell types.	Eicosapentaenoic Acid	68-71	ATP binding cassette subfamily A member 1	Homo sapiens	115-120	
28739279-6	2017	EPA 70muM reduced ABCA1-mediated cholesterol efflux to apolipoprotein (apo) AI by 30% without any alteration in ABCA1 expression.	Eicosapentaenoic Acid	0-3	ATP binding cassette subfamily A member 1	Homo sapiens	18-23	
26776055-0	2016	Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages.	Eicosapentaenoic Acid	0-21	ATP binding cassette subfamily A member 1	Homo sapiens	53-58	
26776055-5	2016	Importantly, eicosapentaenoic acid (EPA) (C20:5 n-3) induced a dose-dependent reduction of ABCA1 functionality in both cellular models (-28% for 70muM of EPA in HMDM), without any alterations in ABCA1 expression.	Eicosapentaenoic Acid	13-34	ATP binding cassette subfamily A member 1	Homo sapiens	91-96	
26776055-5	2016	Importantly, eicosapentaenoic acid (EPA) (C20:5 n-3) induced a dose-dependent reduction of ABCA1 functionality in both cellular models (-28% for 70muM of EPA in HMDM), without any alterations in ABCA1 expression.	Eicosapentaenoic Acid	36-39	ATP binding cassette subfamily A member 1	Homo sapiens	91-96	
26776055-5	2016	Importantly, eicosapentaenoic acid (EPA) (C20:5 n-3) induced a dose-dependent reduction of ABCA1 functionality in both cellular models (-28% for 70muM of EPA in HMDM), without any alterations in ABCA1 expression.	Eicosapentaenoic Acid	36-39	ATP binding cassette subfamily A member 1	Homo sapiens	195-200	
26776055-5	2016	Importantly, eicosapentaenoic acid (EPA) (C20:5 n-3) induced a dose-dependent reduction of ABCA1 functionality in both cellular models (-28% for 70muM of EPA in HMDM), without any alterations in ABCA1 expression.	Eicosapentaenoic Acid	154-157	ATP binding cassette subfamily A member 1	Homo sapiens	91-96	
26776055-9	2016	Moreover, the activation of adenylate cyclase by forskolin and the inhibition of cAMP phosphodiesterase by isobutylmethylxanthine restored ABCA1 cholesterol efflux in EPA-treated human macrophages.	Eicosapentaenoic Acid	167-170	ATP binding cassette subfamily A member 1	Homo sapiens	139-144	
21151462-2	2010	This study uses a real time RT-PCR technique to investigate the role of conjugated linoleic acid (CLA), alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) in the regulation of the ATP-binding cassette A1 (ABCA1) and liver X receptor alpha (LXR) genes, which are involved in cholesterol homeostasis.	Eicosapentaenoic Acid	135-156	ATP binding cassette subfamily A member 1	Homo sapiens	188-211	
21151462-2	2010	This study uses a real time RT-PCR technique to investigate the role of conjugated linoleic acid (CLA), alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) in the regulation of the ATP-binding cassette A1 (ABCA1) and liver X receptor alpha (LXR) genes, which are involved in cholesterol homeostasis.	Eicosapentaenoic Acid	135-156	ATP binding cassette subfamily A member 1	Homo sapiens	213-218	
21151462-2	2010	This study uses a real time RT-PCR technique to investigate the role of conjugated linoleic acid (CLA), alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) in the regulation of the ATP-binding cassette A1 (ABCA1) and liver X receptor alpha (LXR) genes, which are involved in cholesterol homeostasis.	Eicosapentaenoic Acid	158-161	ATP binding cassette subfamily A member 1	Homo sapiens	188-211	
21151462-2	2010	This study uses a real time RT-PCR technique to investigate the role of conjugated linoleic acid (CLA), alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) in the regulation of the ATP-binding cassette A1 (ABCA1) and liver X receptor alpha (LXR) genes, which are involved in cholesterol homeostasis.	Eicosapentaenoic Acid	158-161	ATP binding cassette subfamily A member 1	Homo sapiens	213-218	
34217521-0	2021	Editorial expression of concern: "Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells"(Atherosclerosis Volume 204, Issue 2, June 2009, Pages e35-e43).	Eicosapentaenoic Acid	34-55	ATP binding cassette subfamily A member 1	Homo sapiens	64-69	
34217521-0	2021	Editorial expression of concern: "Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells"(Atherosclerosis Volume 204, Issue 2, June 2009, Pages e35-e43).	Eicosapentaenoic Acid	34-55	ATP binding cassette subfamily A member 1	Homo sapiens	105-110