PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 0-21 interleukin 1 beta Rattus norvegicus 290-307 16141635-2 2005 DHA and eicosapentaenoic acid slightly enhanced IL-1beta-induced cyclooxygenase (COX)-2, but not COX-1, expression, whereas arachidonic acid had no effect. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 48-56 18054352-13 2008 The mRNA of metalloproteinases, interleukin-1beta, interleukin-1r, prostaglandin E synthase (Ptges), and nuclear factor (NF)-kappaB were reduced in the EPA group. Eicosapentaenoic Acid 152-155 interleukin 1 beta Rattus norvegicus 32-49 18424607-2 2008 In this study, the mechanisms by which eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and arachidonic acid (AA) modulate neurotransmitters, behavior, and brain inflammation were evaluated in rats that received central saline or interleukin-1beta (IL-1) administrations. Eicosapentaenoic Acid 62-65 interleukin 1 beta Rattus norvegicus 238-255 15560787-4 2004 Incorporation of EPA or DHA into SMC, which are then activated by interleukin-1beta to mimic inflammation, decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein. Eicosapentaenoic Acid 17-20 interleukin 1 beta Rattus norvegicus 66-83 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 0-21 interleukin 1 beta Rattus norvegicus 309-317 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 23-26 interleukin 1 beta Rattus norvegicus 290-307 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 23-26 interleukin 1 beta Rattus norvegicus 309-317 12562859-3 2003 This study was designed to investigate the effects of membrane incorporation of two major components of fish oil [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], on rat smooth muscle cells (SMCs) activation induced by interleukin-1 beta (IL1 beta). Eicosapentaenoic Acid 114-135 interleukin 1 beta Rattus norvegicus 231-249 15060086-4 2004 The purpose of this study was to determine whether dietary supplements of EPA would attenuate the inflammation-induced impairment of spatial memory by centrally administered IL-1beta. Eicosapentaenoic Acid 74-77 interleukin 1 beta Rattus norvegicus 174-182 14525971-9 2003 Significantly, EPA treatment enhanced hippocampal IL-10 concentration that was inversely correlated with IL-1 beta concentration. Eicosapentaenoic Acid 15-18 interleukin 1 beta Rattus norvegicus 105-114 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Eicosapentaenoic Acid 0-3 interleukin 1 beta Rattus norvegicus 91-99 12562859-10 2003 These results indicate that EPA and DHA act in opposition to AA by modulating various steps of the inflammatory process induced by IL1 beta, probably by reducing mitogen-activated protein kinase p42/p44 activity. Eicosapentaenoic Acid 28-31 interleukin 1 beta Rattus norvegicus 131-139 15165704-5 2004 Significantly, treatment of aged rats with eicosapentaenoic acid reversed the age-related increases in IL-1beta and IL-1beta-induced signalling and also the age-related changes in IL-4, ERK and PI-3 kinase. Eicosapentaenoic Acid 43-64 interleukin 1 beta Rattus norvegicus 103-111 15165704-5 2004 Significantly, treatment of aged rats with eicosapentaenoic acid reversed the age-related increases in IL-1beta and IL-1beta-induced signalling and also the age-related changes in IL-4, ERK and PI-3 kinase. Eicosapentaenoic Acid 43-64 interleukin 1 beta Rattus norvegicus 116-124 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Eicosapentaenoic Acid 48-69 interleukin 1 beta Rattus norvegicus 220-228 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Eicosapentaenoic Acid 71-74 interleukin 1 beta Rattus norvegicus 220-228 12091394-6 2002 These changes were coupled with an age-related deficit in long term potentiation in perforant path-granule cell synapses, while eicosapentaenoate treatment was associated with reversal of age-related changes in interleukin-1beta and p38 and with restoration of long term potentiation. Eicosapentaenoic Acid 128-145 interleukin 1 beta Rattus norvegicus 211-228 12091394-0 2002 Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. Eicosapentaenoic Acid 128-149 interleukin 1 beta Rattus norvegicus 53-70 12091394-2 2002 This study investigated the possibility that treatment with the polyunsaturated fatty acid eicosapentaenoic acid might prevent interleukin-1beta-induced deterioration in neuronal function. Eicosapentaenoic Acid 91-112 interleukin 1 beta Rattus norvegicus 127-144 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 98-106 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Eicosapentaenoic Acid 31-34 interleukin 1 beta Rattus norvegicus 98-106 29627845-9 2018 Levels of IL-1beta, TNF-alpha, and IL-18 were significantly reduced after EPA treatment. Eicosapentaenoic Acid 74-77 interleukin 1 beta Rattus norvegicus 10-18 30189852-5 2018 Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. Eicosapentaenoic Acid 38-41 interleukin 1 beta Rattus norvegicus 115-123 30189852-5 2018 Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. Eicosapentaenoic Acid 38-41 interleukin 1 beta Rattus norvegicus 161-169 30189852-7 2018 CONCLUSIONS: Our data indicate that EPA elicited neuroprotection toward IL-1beta-induced cell damage and BDNF decrease and that its effects potentially occurred via the Akt/CREB signaling pathway. Eicosapentaenoic Acid 36-39 interleukin 1 beta Rattus norvegicus 72-80 30189852-0 2018 Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1beta-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. Eicosapentaenoic Acid 71-74 interleukin 1 beta Rattus norvegicus 83-100 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 90-111 interleukin 1 beta Rattus norvegicus 188-205 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 90-111 interleukin 1 beta Rattus norvegicus 207-215 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 113-116 interleukin 1 beta Rattus norvegicus 188-205 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 113-116 interleukin 1 beta Rattus norvegicus 207-215 28523372-0 2018 Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1beta administration. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 217-234