PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21497077-8	2012	Eicosapentaenoic acid treatment (24 h), alone and in the presence of TNF-alpha,  also decreased adipose triglyceride lipase (ATGL) protein content in cultured adipocytes.	Eicosapentaenoic Acid	0-21	tumor necrosis factor	Rattus norvegicus	69-78	
7596352-3	1995	Incubation of macrophages with 100 microM docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) increased TNF (21% and 15% respectively) and IL6 (69% and 40% respectively) production.	Eicosapentaenoic Acid	73-94	tumor necrosis factor	Rattus norvegicus	111-114	
21497077-4	2012	The EPA effects on basal and TNF-alpha-induced lipolysis were determined in both primary rat and 3T3-L1 adipocytes.	Eicosapentaenoic Acid	4-7	tumor necrosis factor	Rattus norvegicus	29-38	
21497077-6	2012	Moreover, EPA decreased TNF-alpha-induced activation of nuclear factor-kappaB and extracellular-related kinase 1/2 phosphorylation.	Eicosapentaenoic Acid	10-13	tumor necrosis factor	Rattus norvegicus	24-33	
21571092-6	2011	Joint treatment with EPA (300mg/kg) blunted the oxidative stress, TNF-alpha levels and MPO activity, while enhanced levels of serum albumin and hepatic GSH.	Eicosapentaenoic Acid	21-24	tumor necrosis factor	Rattus norvegicus	66-75	
20885391-13	2011	Concerning the inflammatory status, EPA treatment resulted in a decreased gene expression for both tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) both in skeletal muscle and adipose tissue.	Eicosapentaenoic Acid	36-39	tumor necrosis factor	Rattus norvegicus	99-126	
20885391-13	2011	Concerning the inflammatory status, EPA treatment resulted in a decreased gene expression for both tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) both in skeletal muscle and adipose tissue.	Eicosapentaenoic Acid	36-39	tumor necrosis factor	Rattus norvegicus	128-137	
19741054-5	2009	EPA administration decreased the external signs of arthritis and paw volume as well as liver TNF-alpha mRNA.	Eicosapentaenoic Acid	0-3	tumor necrosis factor	Rattus norvegicus	93-102	
19741054-7	2009	However, EPA treatment prevented arthritis-induced increase in muscle TNF-alpha and atrogin-1, whereas it attenuated the decrease in gastrocnemius weight and the increase in MuRF1 mRNA.	Eicosapentaenoic Acid	9-12	tumor necrosis factor	Rattus norvegicus	70-79	
7596352-3	1995	Incubation of macrophages with 100 microM docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) increased TNF (21% and 15% respectively) and IL6 (69% and 40% respectively) production.	Eicosapentaenoic Acid	96-99	tumor necrosis factor	Rattus norvegicus	111-114	
33838352-9	2021	EPA and DHA could decrease the MTX-induced increase in the histopathological injury score, splenic hemosiderin, splenic MDA, mRNA expression of TNFalpha, caspase-3 and could increase the MTX-induced decrease in Splenic GSH and mRNA expression for Bcl-2.	Eicosapentaenoic Acid	0-3	tumor necrosis factor	Rattus norvegicus	144-152	
28523372-11	2018	EPA supplement normalized the n-3 and n-6 PUFA profiles and cPLA2 levels, inhibited glial activation, reduced APP and TNF-alpha expression, as well as up-regulated BDNF and TrKB.	Eicosapentaenoic Acid	0-3	tumor necrosis factor	Rattus norvegicus	118-127	
32150824-8	2020	However, even though CUMS-induced microglial activation and associated increased IL-1beta were inhibited by both EPA and DHA supplement, increased IL-6 and TNF-alpha levels were only reduced by EPA.	Eicosapentaenoic Acid	194-197	tumor necrosis factor	Rattus norvegicus	156-165	
29627845-9	2018	Levels of IL-1beta, TNF-alpha, and IL-18 were significantly reduced after EPA treatment.	Eicosapentaenoic Acid	74-77	tumor necrosis factor	Rattus norvegicus	20-29