PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30511301-10	2019	Our small sample size study demonstrated an increase FADS1expression during pregnancy in vegetarian pregnant women that may have contributed to the maintenance of AA, eicosapentaenoic acid and DHA levels thereby ensuring that the overall LCPUFA levels of the neonate is not compromised.	Eicosapentaenoic Acid	167-188	fatty acid desaturase 1	Homo sapiens	53-58	
33530084-7	2021	In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels.	Eicosapentaenoic Acid	246-267	fatty acid desaturase 1	Homo sapiens	33-38	
33530084-7	2021	In addition, genetic variants in FADS1, FADS2, ELOV-2, and ELOV-5 lead to a more efficient biosynthesis of long-chain polyunsaturated fatty acids (PUFAs), e.g., of linoleic acid (LA) to arachidonic acid (ARA), and (alpha-linolenic acid) (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), leading to higher ARA levels.	Eicosapentaenoic Acid	269-272	fatty acid desaturase 1	Homo sapiens	33-38	
29746616-2	2018	Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	103-106	fatty acid desaturase 1	Homo sapiens	0-23	
29746616-2	2018	Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	103-106	fatty acid desaturase 1	Homo sapiens	25-30	
29549917-4	2018	At 3-years of follow-up, after adjustment for age, sex, smoking and drinking, there were interaction effects between the FADS1 rs174547 T > C genotype and baseline BMI on the changes (from baseline) in plasma arachidonic acid (AA) levels, in the eicosapentaenoic acid (EPA)/AA ratio, and in ba-PWV (p for interaction = 0.036, 0.022, and 0.001, respectively).	Eicosapentaenoic Acid	249-270	fatty acid desaturase 1	Homo sapiens	121-126	
29722844-12	2018	Conclusions: Carriers of the T allele at FADS1 rs174546 may need higher doses of dietary EPA and DHA to achieve the same circulating proportions of EPA as carriers of the C allele.	Eicosapentaenoic Acid	89-92	fatty acid desaturase 1	Homo sapiens	41-46	
29722844-12	2018	Conclusions: Carriers of the T allele at FADS1 rs174546 may need higher doses of dietary EPA and DHA to achieve the same circulating proportions of EPA as carriers of the C allele.	Eicosapentaenoic Acid	148-151	fatty acid desaturase 1	Homo sapiens	41-46	
29549917-4	2018	At 3-years of follow-up, after adjustment for age, sex, smoking and drinking, there were interaction effects between the FADS1 rs174547 T > C genotype and baseline BMI on the changes (from baseline) in plasma arachidonic acid (AA) levels, in the eicosapentaenoic acid (EPA)/AA ratio, and in ba-PWV (p for interaction = 0.036, 0.022, and 0.001, respectively).	Eicosapentaenoic Acid	272-275	fatty acid desaturase 1	Homo sapiens	121-126	
29549917-7	2018	The minor allele of the FADS1 rs174547 polymorphism is associated with age-related decreases in the EPA/AA ratio and increases in ba-PWV among overweight subjects.	Eicosapentaenoic Acid	100-103	fatty acid desaturase 1	Homo sapiens	24-29	
28186827-6	2017	EPA and DHA are also produced endogenously to a limited extent through a pathway regulated by fatty acid desaturase 1 and 2 (FADS1 and FADS2) genes.	Eicosapentaenoic Acid	0-3	fatty acid desaturase 1	Homo sapiens	94-123	
28186827-6	2017	EPA and DHA are also produced endogenously to a limited extent through a pathway regulated by fatty acid desaturase 1 and 2 (FADS1 and FADS2) genes.	Eicosapentaenoic Acid	0-3	fatty acid desaturase 1	Homo sapiens	125-130	
26092623-5	2015	Similarly, decreased FADS1 gene expression was paralleled by lowered arachidonic acid (20:4 n-6) and eicosapentaenoic acid (20:5 n-3) contents, while the down-regulation of FADS2 expression was accompanied by a diminished docosahexaenoic acid (22:6 n-3) content.	Eicosapentaenoic Acid	101-122	fatty acid desaturase 1	Homo sapiens	21-26	
25981324-7	2015	Furthermore, the ratio of eicosapentaenoic acid/alpha-linolenic acid (EPA/ALA), which reflects Delta5 desaturase activity, was markedly decreased in T2DM patients.	Eicosapentaenoic Acid	26-47	fatty acid desaturase 1	Homo sapiens	101-112	
25849351-3	2015	The aim of this study was to evaluate whether dietary n-3 long-chain polyunsaturated fatty acids (LCPUFAs)-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could modulate the effect of FADS1 rs174547 polymorphism on CAD.	Eicosapentaenoic Acid	107-128	fatty acid desaturase 1	Homo sapiens	195-200	
25849351-3	2015	The aim of this study was to evaluate whether dietary n-3 long-chain polyunsaturated fatty acids (LCPUFAs)-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could modulate the effect of FADS1 rs174547 polymorphism on CAD.	Eicosapentaenoic Acid	130-133	fatty acid desaturase 1	Homo sapiens	195-200	
25849351-8	2015	RESULTS: We found that the minor T allele of FADS1 rs174547 increased CAD risk (OR = 1.36, 95%CIs 1.03-1.80), and observed significant interaction between rs174547 and dietary EPA intakes on CAD (P-interaction = 0.028).	Eicosapentaenoic Acid	176-179	fatty acid desaturase 1	Homo sapiens	45-50	
22095831-5	2012	We found that both DHA and EPA suppress the expression and activity of Delta5- and Delta6-desaturases, leading to decreased flux through the n-3 and n-6 PUFA metabolic pathways and decreased production of AA.	Eicosapentaenoic Acid	27-30	fatty acid desaturase 1	Homo sapiens	89-101	
24842322-2	2014	Two desaturase steps (Delta6, encoded by FADS2 and Delta5, encoded by FADS1) are rate limiting in the conversion of dietary essential 18 carbon PUFAs (18C-PUFAs) such as LA (18:2, n-6) to AA and alpha-linolenic acid (ALA, 18:3, n-3) to EPA and DHA.	Eicosapentaenoic Acid	236-239	fatty acid desaturase 1	Homo sapiens	70-75	
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	292-295	fatty acid desaturase 1	Homo sapiens	60-65	
14988642-5	2004	In groups of subjects with low vitamin B6 and low iron levels, delta6-desaturase activity together with delta5-desaturase activity (conversion of alpha-linolenic/18:3,n-3/ into eicosapentaenoic acid/20:5,n-3/) as well as the conversion index of docosahexaenoic acid formation (22:6,n-3) from 22:5,n-3 (second delta6-desaturase activity) were significantly reduced.	Eicosapentaenoic Acid	177-198	fatty acid desaturase 1	Homo sapiens	104-121	
21829377-3	2011	Minor alleles of SNPs in FADS1 and FADS2 (desaturases) were associated with higher levels of ALA (p = 3 x 10-64) and lower levels of eicosapentaenoic acid (EPA, p = 5 x 10-58) and docosapentaenoic acid (DPA, p = 4 x 10-154).	Eicosapentaenoic Acid	133-154	fatty acid desaturase 1	Homo sapiens	25-30	
21829377-3	2011	Minor alleles of SNPs in FADS1 and FADS2 (desaturases) were associated with higher levels of ALA (p = 3 x 10-64) and lower levels of eicosapentaenoic acid (EPA, p = 5 x 10-58) and docosapentaenoic acid (DPA, p = 4 x 10-154).	Eicosapentaenoic Acid	156-159	fatty acid desaturase 1	Homo sapiens	25-30	
18842780-1	2008	BACKGROUND: The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA).	Eicosapentaenoic Acid	269-290	fatty acid desaturase 1	Homo sapiens	60-65	
10917903-4	2000	Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of eicosapentaenoic acid (EPA) blocked Delta-5-desaturase activity, the terminal enzymatic step in AA synthesis.	Eicosapentaenoic Acid	80-101	fatty acid desaturase 1	Homo sapiens	116-134	
10917903-4	2000	Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of eicosapentaenoic acid (EPA) blocked Delta-5-desaturase activity, the terminal enzymatic step in AA synthesis.	Eicosapentaenoic Acid	103-106	fatty acid desaturase 1	Homo sapiens	116-134	
7775867-6	1995	When the media was supplemented with either linoleic acid and/or EPA, both delta 6 and delta 5 desaturase activities were inhibited, the greatest reduction of delta 5 desaturase activity occurring with EPA.	Eicosapentaenoic Acid	65-68	fatty acid desaturase 1	Homo sapiens	87-105	
7775867-6	1995	When the media was supplemented with either linoleic acid and/or EPA, both delta 6 and delta 5 desaturase activities were inhibited, the greatest reduction of delta 5 desaturase activity occurring with EPA.	Eicosapentaenoic Acid	202-205	fatty acid desaturase 1	Homo sapiens	87-105