PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30400671-3	2018	Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 polyunsaturated fatty acids may compete with AA for CYP450-dependent bioactive lipid mediator formation.	Eicosapentaenoic Acid	0-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-125	
18978038-1	2009	Human cytochrome P-450 epoxygenase enzymes metabolize eicosapentaenoic acid (EPA), an omega-3-polyunsaturated fatty acid (PUFA), and leads to the production of 17(18)-epoxyeicosatetraenoic acid, or 17(18)-EpETE.	Eicosapentaenoic Acid	54-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-22	
18978038-1	2009	Human cytochrome P-450 epoxygenase enzymes metabolize eicosapentaenoic acid (EPA), an omega-3-polyunsaturated fatty acid (PUFA), and leads to the production of 17(18)-epoxyeicosatetraenoic acid, or 17(18)-EpETE.	Eicosapentaenoic Acid	77-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	6-22	
1771239-3	1991	We investigated whether dietary eicosapentaenoic acid could also be metabolized by cytochrome P-450, by assessing the excretion of its vicinal diols.	Eicosapentaenoic Acid	32-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	83-99	
23224081-5	2013	Mass spectrometric analysis identified CYP2S1 as a novel macrophage CYP and CYP2S1-containing microsomes generated epoxides of arachidonic, linoleic and eicosapentaenoic acid.	Eicosapentaenoic Acid	153-174	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-42	
21309752-4	2011	Co-expression of CYP33E2 with the human NADPH-CYP reductase in insect cells resulted in the reconstitution of an active microsomal mono-oxygenase system that metabolized EPA (eicosapentaenoic acid) and, with lower activity, also AA to specific sets of regioisomeric epoxy- and hydroxy-derivatives.	Eicosapentaenoic Acid	170-173	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20	
21309752-4	2011	Co-expression of CYP33E2 with the human NADPH-CYP reductase in insect cells resulted in the reconstitution of an active microsomal mono-oxygenase system that metabolized EPA (eicosapentaenoic acid) and, with lower activity, also AA to specific sets of regioisomeric epoxy- and hydroxy-derivatives.	Eicosapentaenoic Acid	175-196	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20	
21309752-8	2011	These results demonstrate that EPA and AA are efficient CYP33E2 substrates and suggest that CYP-eicosanoids, influencing in mammals the contractility of cardiomyocytes and vascular smooth muscle cells, may function in C. elegans as regulators of the pharyngeal pumping activity.	Eicosapentaenoic Acid	31-34	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-59	
20869469-2	2011	As discussed in the present review, virtually all of the major AA metabolizing CYP isoforms accept a variety of other polyunsaturated fatty acids (PUFA), including linoleic, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), as efficient alternative substrates.	Eicosapentaenoic Acid	192-195	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82	
31733338-5	2020	Members of omega-3 as well as omega-6 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid and arachidonic acid, respectively, can be metabolized by CYP isoforms leading to the production of biologically active lipid mediators called eicosanoids.	Eicosapentaenoic Acid	82-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-165	
30400671-3	2018	Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 polyunsaturated fatty acids may compete with AA for CYP450-dependent bioactive lipid mediator formation.	Eicosapentaenoic Acid	23-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	119-125	
29080699-3	2018	CYP enzymes, previously identified as arachidonic acid (20:4n-6; AA) epoxygenases, accept eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA), the major fish oil n-3 LC-PUFAs, as efficient alternative substrates.	Eicosapentaenoic Acid	90-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
26975734-3	2016	In addition to arachidonic acid, the CYP epoxygenases also metabolize the Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid and docosahexaenoic acid, to generate bioactive lipid epoxide mediators.	Eicosapentaenoic Acid	119-140	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	37-40