PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33471425-3 2021 There is also emerging evidence, which suggests that high intakes of the plant-based essential fatty acids (ePUFAs)-n-6 linoleic acid (LA) and n-3 alpha-linolenic acid (ALA)-have a greater impact on body composition (fat mass and lean mass) and on glucose homeostasis than the marine-derived long-chain n-3 PUFA-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 335-338 pumilio RNA binding family member 3 Homo sapiens 109-113 33619024-7 2021 Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). Eicosapentaenoic Acid 94-115 pumilio RNA binding family member 3 Homo sapiens 75-79 33933722-1 2021 BACKGROUND & AIMS: Marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower circulating levels of triacylglycerols (TAGs), and the plant-derived omega-6 (n-6) PUFA linoleic acid (LA) may reduce cholesterol levels. Eicosapentaenoic Acid 92-113 pumilio RNA binding family member 3 Homo sapiens 77-81 32829640-6 2020 In the shake flask fermentation, the lipid and PUFA yields of the mutant were increased by 26.9 and 36.0%, respectively, and led to about 5-fold increase of the EPA yield. Eicosapentaenoic Acid 161-164 pumilio RNA binding family member 3 Homo sapiens 47-51 32431176-1 2021 Dietary omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) like eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) are known to be potent biological regulators with therapeutic and preventive effects on human health. Eicosapentaenoic Acid 74-95 pumilio RNA binding family member 3 Homo sapiens 63-67 32431176-1 2021 Dietary omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) like eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) are known to be potent biological regulators with therapeutic and preventive effects on human health. Eicosapentaenoic Acid 97-100 pumilio RNA binding family member 3 Homo sapiens 63-67 33123975-13 2021 However, n-3 PUFA derived from plants significantly reduced TC and LDL-C concentrations, and n-3 PUFA derived from EPA and DHA significantly reduced TG concentration and increased HDL-C concentration. Eicosapentaenoic Acid 115-118 pumilio RNA binding family member 3 Homo sapiens 97-101 33516004-7 2021 At day 91, the percentage differences between control and n-3 LC-PUFA heifers in concentrations of eicosapentaenoic acid were +61, +176 and +133 % in liver, muscle and adipose, respectively. Eicosapentaenoic Acid 99-120 pumilio RNA binding family member 3 Homo sapiens 65-69 32308554-3 2020 Among PUFA-derived proresolving mediators, different eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derivatives have been described, namely, resolvins (resolution phase interaction products), which exert their anti-inflammatory and immune-regulatory activities through specific G-protein-coupled receptors. Eicosapentaenoic Acid 53-74 pumilio RNA binding family member 3 Homo sapiens 6-10 30959386-5 2019 RESULTS: We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Eicosapentaenoic Acid 92-113 pumilio RNA binding family member 3 Homo sapiens 178-182 31752421-4 2019 Vl-PUFA, especially the omega-3 fatty acid EPA, is essential in human diet for its benefits on healthy brain development and inflammation modulation. Eicosapentaenoic Acid 43-46 pumilio RNA binding family member 3 Homo sapiens 3-7 31426362-3 2019 We also hypothesized that omega3-PUFA supplementation resulted in additional benefit in participants with a low docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) erythrocyte level at baseline and high adherence to the multidomain intervention sessions. Eicosapentaenoic Acid 139-160 pumilio RNA binding family member 3 Homo sapiens 33-37 31426362-3 2019 We also hypothesized that omega3-PUFA supplementation resulted in additional benefit in participants with a low docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) erythrocyte level at baseline and high adherence to the multidomain intervention sessions. Eicosapentaenoic Acid 162-165 pumilio RNA binding family member 3 Homo sapiens 33-37 31320765-1 2019 Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the most important long-chain polyunsaturated fatty acids of the n-3 series (n-3 PUFA). Eicosapentaenoic Acid 0-21 pumilio RNA binding family member 3 Homo sapiens 144-148 31320765-1 2019 Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the most important long-chain polyunsaturated fatty acids of the n-3 series (n-3 PUFA). Eicosapentaenoic Acid 23-26 pumilio RNA binding family member 3 Homo sapiens 144-148 30959386-5 2019 RESULTS: We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Eicosapentaenoic Acid 115-118 pumilio RNA binding family member 3 Homo sapiens 178-182 31003450-6 2019 A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Eicosapentaenoic Acid 146-167 pumilio RNA binding family member 3 Homo sapiens 106-110 31017945-1 2019 Fish are rich in n-3 long-chain polyunsaturated fatty acids (LC-PUFA), such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, thus they have a great nutritional value for human health. Eicosapentaenoic Acid 97-100 pumilio RNA binding family member 3 Homo sapiens 64-68 31126106-6 2019 The estimated daily omega-3 LC-PUFA intake (EPA + DHA) was significantly below that recommended by the public health agencies in both groups, and was significantly lower in children with ADHD (p < 0.05, Cohen"s d = 0.45) compared to normally developing children. Eicosapentaenoic Acid 44-47 pumilio RNA binding family member 3 Homo sapiens 31-35 31006007-2 2019 Some intervention studies have demonstrated that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increase systemic concentrations of n-3 PUFA-derived oxylipins and moderately decrease arachidonic acid-derived oxylipins. Eicosapentaenoic Acid 49-70 pumilio RNA binding family member 3 Homo sapiens 148-152 31006007-2 2019 Some intervention studies have demonstrated that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increase systemic concentrations of n-3 PUFA-derived oxylipins and moderately decrease arachidonic acid-derived oxylipins. Eicosapentaenoic Acid 72-75 pumilio RNA binding family member 3 Homo sapiens 148-152 31005937-5 2019 To estimate the total LC omega-3 PUFA levels (eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]) that these norms produce we utilised a metric that accounts for (1) seafood-based omega-3 intake (EPA/DHA) and (2) plant-based omega-3 intake (alpha-linolenic acid [ALA]), ~20% of which is converted to EPA/DHA in vivo. Eicosapentaenoic Acid 46-67 pumilio RNA binding family member 3 Homo sapiens 33-37 31005937-5 2019 To estimate the total LC omega-3 PUFA levels (eicosapentaenoic acid [EPA]/docosahexaenoic acid [DHA]) that these norms produce we utilised a metric that accounts for (1) seafood-based omega-3 intake (EPA/DHA) and (2) plant-based omega-3 intake (alpha-linolenic acid [ALA]), ~20% of which is converted to EPA/DHA in vivo. Eicosapentaenoic Acid 69-72 pumilio RNA binding family member 3 Homo sapiens 33-37 30899221-4 2019 SPMs are multiple hydroxylated fatty acids including resolvins, maresins, and protectins derived from the n3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as lipoxins derived from arachidonic acid (ARA). Eicosapentaenoic Acid 114-135 pumilio RNA binding family member 3 Homo sapiens 109-113 30899221-4 2019 SPMs are multiple hydroxylated fatty acids including resolvins, maresins, and protectins derived from the n3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as lipoxins derived from arachidonic acid (ARA). Eicosapentaenoic Acid 137-140 pumilio RNA binding family member 3 Homo sapiens 109-113 31641729-7 2019 RBC n-3 PUFA concentration was defined by % of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) among total fatty acids. Eicosapentaenoic Acid 78-99 pumilio RNA binding family member 3 Homo sapiens 8-12 30621155-7 2019 We conclude that all the new sources have potentially important roles to play in increasing the supply of n-3 LC-PUFA so that they are available more widely and in higher concentrations providing more options and opportunities for human consumers to obtain sufficient EPA and DHA to support more healthy, balanced diets. Eicosapentaenoic Acid 268-271 pumilio RNA binding family member 3 Homo sapiens 113-117 31641729-7 2019 RBC n-3 PUFA concentration was defined by % of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) among total fatty acids. Eicosapentaenoic Acid 101-104 pumilio RNA binding family member 3 Homo sapiens 8-12 28987470-9 2018 Enrichment of EicosaPentaenoic Acid (EPA) and DocosaHexaenoic Acid (DHA) in erythrocytes increased significantly in patients supplemented with omega-3 long chain-PUFA compared with the placebo group during the 6 months of supplementation. Eicosapentaenoic Acid 14-35 pumilio RNA binding family member 3 Homo sapiens 162-166 28987470-9 2018 Enrichment of EicosaPentaenoic Acid (EPA) and DocosaHexaenoic Acid (DHA) in erythrocytes increased significantly in patients supplemented with omega-3 long chain-PUFA compared with the placebo group during the 6 months of supplementation. Eicosapentaenoic Acid 37-40 pumilio RNA binding family member 3 Homo sapiens 162-166 30392579-2 2018 N-3 PUFA like eicosapentaenoic acid are subject to a similar metabolism and are precursors of pro-resolving mediators. Eicosapentaenoic Acid 14-35 pumilio RNA binding family member 3 Homo sapiens 4-8 28523372-3 2018 We have previously reported that an n-3 PUFA, eicosapentaenoic acid (EPA), can improve memory and attenuate neurodegeneration-like changes in animal models of AD. Eicosapentaenoic Acid 46-67 pumilio RNA binding family member 3 Homo sapiens 40-44 28523372-3 2018 We have previously reported that an n-3 PUFA, eicosapentaenoic acid (EPA), can improve memory and attenuate neurodegeneration-like changes in animal models of AD. Eicosapentaenoic Acid 69-72 pumilio RNA binding family member 3 Homo sapiens 40-44 28523372-11 2018 EPA supplement normalized the n-3 and n-6 PUFA profiles and cPLA2 levels, inhibited glial activation, reduced APP and TNF-alpha expression, as well as up-regulated BDNF and TrKB. Eicosapentaenoic Acid 0-3 pumilio RNA binding family member 3 Homo sapiens 42-46 29769200-4 2018 There is evidence that consumption of fish oil containing long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic acid (EPA, 20:5Delta5,8,11,14,17) and docosahexaenoic acid (DHA, 22:6Delta4,7,10,13,16,19) may reduce colon cancer risk in humans, yet the mechanism underlying this effect is unknown. Eicosapentaenoic Acid 120-141 pumilio RNA binding family member 3 Homo sapiens 106-110 29769200-4 2018 There is evidence that consumption of fish oil containing long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic acid (EPA, 20:5Delta5,8,11,14,17) and docosahexaenoic acid (DHA, 22:6Delta4,7,10,13,16,19) may reduce colon cancer risk in humans, yet the mechanism underlying this effect is unknown. Eicosapentaenoic Acid 143-146 pumilio RNA binding family member 3 Homo sapiens 106-110 30023865-10 2018 The resulting multicompartment systems and stealth nanosponges may serve as mesoporous reservoirs for coencapsulation of omega-3 PUFA (e.g., EPA) with water-insoluble drugs and hydrophilic macromolecules toward development of combination treatment strategies of neurodegenerative and other diseases. Eicosapentaenoic Acid 141-144 pumilio RNA binding family member 3 Homo sapiens 129-133 29766165-6 2018 EPA supplementation decreased the plasma n-6-PUFA content and increased n-3-PUFAs, mainly EPA and DPA, but not DHA. Eicosapentaenoic Acid 0-3 pumilio RNA binding family member 3 Homo sapiens 45-49 28835582-4 2017 The serum levels of n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid and docosahexaenoic acid, are reportedly associated with an increased incidence of cardiovascular events and mortality, whereas the addition of n-3 PUFA treatment to the statin treatment decreases cardiovascular events. Eicosapentaenoic Acid 71-92 pumilio RNA binding family member 3 Homo sapiens 53-57 28752333-3 2017 In this sense, new families of PUFA-derived lipid mediators, including resolvins derived from EPA and DHA, and protectins and maresins derived from DHA, are being increasingly investigated because of their active role in the "return to homeostasis" process and resolution of inflammation. Eicosapentaenoic Acid 94-97 pumilio RNA binding family member 3 Homo sapiens 31-35 28169288-1 2017 We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent cerebrovascular vasospasm. Eicosapentaenoic Acid 28-49 pumilio RNA binding family member 3 Homo sapiens 100-104 25897862-1 2017 The potential antineoplastic effect of the long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) remains a highly controversial issue. Eicosapentaenoic Acid 118-121 pumilio RNA binding family member 3 Homo sapiens 94-98 28831714-3 2017 The objective of this study was to investigate the associations between the omega-3 PUFA levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) in red blood cell (RBC) membranes and physical performance, in a sample of community-dwelling older adults. Eicosapentaenoic Acid 97-118 pumilio RNA binding family member 3 Homo sapiens 84-88 28682409-1 2017 A growing body of evidence suggests that the intake of the long chain omega-3 polyunsaturated fatty acids (n3-PUFA) eicosapentaenoic acid (C20:5 n3, EPA) and docosahexaenoic acid (C22:6 n3, DHA) is linked to beneficial health effects, particularly in the prevention of cardiovascular and inflammatory diseases. Eicosapentaenoic Acid 116-137 pumilio RNA binding family member 3 Homo sapiens 110-114 28540852-12 2017 Raising the PUFA-omega6/PUFA-omega3 ratio and PUFA-omega6 levels were associated with the drop HDL-c/LDL-c ratio and EPA+DHA drastic depletion. Eicosapentaenoic Acid 117-120 pumilio RNA binding family member 3 Homo sapiens 12-16 28540852-12 2017 Raising the PUFA-omega6/PUFA-omega3 ratio and PUFA-omega6 levels were associated with the drop HDL-c/LDL-c ratio and EPA+DHA drastic depletion. Eicosapentaenoic Acid 117-120 pumilio RNA binding family member 3 Homo sapiens 24-28 28540852-12 2017 Raising the PUFA-omega6/PUFA-omega3 ratio and PUFA-omega6 levels were associated with the drop HDL-c/LDL-c ratio and EPA+DHA drastic depletion. Eicosapentaenoic Acid 117-120 pumilio RNA binding family member 3 Homo sapiens 24-28 28169288-1 2017 We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent cerebrovascular vasospasm. Eicosapentaenoic Acid 309-312 pumilio RNA binding family member 3 Homo sapiens 100-104 28169288-1 2017 We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent cerebrovascular vasospasm. Eicosapentaenoic Acid 51-54 pumilio RNA binding family member 3 Homo sapiens 100-104 27098595-7 2016 Among females, several dietary omega-3 PUFA variables were positively associated with whole blood EPA, with total EPA (rho = 0.67, p < .001) and total DHA (rho = 0.69, p < .001) intakes showing the strongest correlations. Eicosapentaenoic Acid 98-101 pumilio RNA binding family member 3 Homo sapiens 39-43 28135195-6 2017 Significant correlations were observed for LC-PUFA intake estimated using dietary records in both early and late pregnancy, particularly for EPA and DHA (correlation coefficients ranged from 0.34 to 0.40, p < 0.0001). Eicosapentaenoic Acid 141-144 pumilio RNA binding family member 3 Homo sapiens 46-50 27098595-7 2016 Among females, several dietary omega-3 PUFA variables were positively associated with whole blood EPA, with total EPA (rho = 0.67, p < .001) and total DHA (rho = 0.69, p < .001) intakes showing the strongest correlations. Eicosapentaenoic Acid 114-117 pumilio RNA binding family member 3 Homo sapiens 39-43 27070119-6 2016 Based on linear regression models, we predict that global n-3 LC-PUFA production will be reduced by 8.2% for eicosapentaenoic acid (EPA) and 27.8% for docosahexaenoic acid (DHA) with an increase in water temperature of 2.5 C. Using a previously published estimate of the global production of EPA by diatoms, which contribute to most of the world"s supply of EPA, we predict a loss of 14.2 Mt of EPA annually as a result of ocean warming. Eicosapentaenoic Acid 109-130 pumilio RNA binding family member 3 Homo sapiens 65-69 27837747-2 2016 Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA. Eicosapentaenoic Acid 104-107 pumilio RNA binding family member 3 Homo sapiens 42-46 27529771-7 2016 Omega-3 PUFA treatment increased plasma eicosapentaenoic acid (F1,29 = 33.29, P < 0.01) and docosahexaenoic acid (F1,29 = 15.29, P < 0.01) concentrations but did not reduce HAM-D (F3,91 = 1.59, P = 0.20) or BDI-II (F3,91 = 0.46, P = 0.50) scores compared with placebo. Eicosapentaenoic Acid 40-61 pumilio RNA binding family member 3 Homo sapiens 8-12 27070119-6 2016 Based on linear regression models, we predict that global n-3 LC-PUFA production will be reduced by 8.2% for eicosapentaenoic acid (EPA) and 27.8% for docosahexaenoic acid (DHA) with an increase in water temperature of 2.5 C. Using a previously published estimate of the global production of EPA by diatoms, which contribute to most of the world"s supply of EPA, we predict a loss of 14.2 Mt of EPA annually as a result of ocean warming. Eicosapentaenoic Acid 293-296 pumilio RNA binding family member 3 Homo sapiens 65-69 27070119-6 2016 Based on linear regression models, we predict that global n-3 LC-PUFA production will be reduced by 8.2% for eicosapentaenoic acid (EPA) and 27.8% for docosahexaenoic acid (DHA) with an increase in water temperature of 2.5 C. Using a previously published estimate of the global production of EPA by diatoms, which contribute to most of the world"s supply of EPA, we predict a loss of 14.2 Mt of EPA annually as a result of ocean warming. Eicosapentaenoic Acid 293-296 pumilio RNA binding family member 3 Homo sapiens 65-69 27159788-3 2016 METHODS AND RESULTS: Primary human preadipocytes were treated with n-3 PUFAs (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) or n-6 PUFA (arachidonic acid, ARA) during differentiation, and adipogenesis, white and brite gene expression markers, mitochondrial content and function were analyzed at day 12 of differentiation. Eicosapentaenoic Acid 78-99 pumilio RNA binding family member 3 Homo sapiens 71-75 27499701-1 2016 BACKGROUND: Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)-docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)- and omega-6 LC-PUFA arachidonic acid (ARA), are essential for optimum physical and mental development in children. Eicosapentaenoic Acid 153-156 pumilio RNA binding family member 3 Homo sapiens 63-67 27070119-6 2016 Based on linear regression models, we predict that global n-3 LC-PUFA production will be reduced by 8.2% for eicosapentaenoic acid (EPA) and 27.8% for docosahexaenoic acid (DHA) with an increase in water temperature of 2.5 C. Using a previously published estimate of the global production of EPA by diatoms, which contribute to most of the world"s supply of EPA, we predict a loss of 14.2 Mt of EPA annually as a result of ocean warming. Eicosapentaenoic Acid 132-135 pumilio RNA binding family member 3 Homo sapiens 65-69 27070119-6 2016 Based on linear regression models, we predict that global n-3 LC-PUFA production will be reduced by 8.2% for eicosapentaenoic acid (EPA) and 27.8% for docosahexaenoic acid (DHA) with an increase in water temperature of 2.5 C. Using a previously published estimate of the global production of EPA by diatoms, which contribute to most of the world"s supply of EPA, we predict a loss of 14.2 Mt of EPA annually as a result of ocean warming. Eicosapentaenoic Acid 293-296 pumilio RNA binding family member 3 Homo sapiens 65-69 29648713-2 2016 PUFA n-3 contained in marine fish oils, particularly eicosapentaenoic (EPA, 20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) acids, are attributed antithrombotic, anti-inflammatory, anti-atherosclerotic and anti-arrhythmic effects. Eicosapentaenoic Acid 71-74 pumilio RNA binding family member 3 Homo sapiens 0-4 27273350-3 2016 METHODS: The present study examined the LC PUFA status of MCI patients with specific view on the relative LC n-3 PUFA levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocyte membranes (omega-3 index). Eicosapentaenoic Acid 128-149 pumilio RNA binding family member 3 Homo sapiens 113-117 25885465-5 2015 Moderate-high correlations between the FFQ-derived PUFA intake estimates and blood biomarker PUFA levels were shown only for eicosapentaenoic acid (EPA; 0.55) and docosahexaenoic acid (DHA; 0.61). Eicosapentaenoic Acid 125-146 pumilio RNA binding family member 3 Homo sapiens 51-55 25208630-7 2015 RESULTS: Based on covariate-adjusted analyses, intakes of n-3 PUFAs from vegetable sources were significantly correlated with RBC alpha-linolenic acid levels (rho = 0.23, P = 0.007), whereas n-3 PUFA intakes from marine sources correlated significantly with RBC eicosapentaenoic acid (rho = 0.29, P = 0.0008) and docosahexaenoic acid (rho = 0.41, P = 9.2 x 10(-7)) levels. Eicosapentaenoic Acid 262-283 pumilio RNA binding family member 3 Homo sapiens 62-66 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Eicosapentaenoic Acid 208-229 pumilio RNA binding family member 3 Homo sapiens 74-78 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Eicosapentaenoic Acid 208-229 pumilio RNA binding family member 3 Homo sapiens 163-167 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Eicosapentaenoic Acid 231-234 pumilio RNA binding family member 3 Homo sapiens 74-78 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Eicosapentaenoic Acid 231-234 pumilio RNA binding family member 3 Homo sapiens 163-167 25885465-5 2015 Moderate-high correlations between the FFQ-derived PUFA intake estimates and blood biomarker PUFA levels were shown only for eicosapentaenoic acid (EPA; 0.55) and docosahexaenoic acid (DHA; 0.61). Eicosapentaenoic Acid 125-146 pumilio RNA binding family member 3 Homo sapiens 93-97 25885465-5 2015 Moderate-high correlations between the FFQ-derived PUFA intake estimates and blood biomarker PUFA levels were shown only for eicosapentaenoic acid (EPA; 0.55) and docosahexaenoic acid (DHA; 0.61). Eicosapentaenoic Acid 148-151 pumilio RNA binding family member 3 Homo sapiens 51-55 25885465-5 2015 Moderate-high correlations between the FFQ-derived PUFA intake estimates and blood biomarker PUFA levels were shown only for eicosapentaenoic acid (EPA; 0.55) and docosahexaenoic acid (DHA; 0.61). Eicosapentaenoic Acid 148-151 pumilio RNA binding family member 3 Homo sapiens 93-97 26392837-4 2014 Evidence from genome wide association studies has consistently demonstrated that plasma and tissue levels of the n-6 long-chain PUFA arachidonic acid and to a lesser extent the n-3 long-chain PUFA eicosapentaenoic acid, are strongly influenced by variation in fatty acid desaturase-1,-2, and elongation of very long chain fatty acid genes. Eicosapentaenoic Acid 197-218 pumilio RNA binding family member 3 Homo sapiens 192-196 25577352-11 2015 In this study, we developed an accurate, precise, and novel analytical method for estimating the omega-6 and omega-3 PUFA metabolites, and this is the first report that the SPMs derived from EPA and DHA are present in human urine. Eicosapentaenoic Acid 191-194 pumilio RNA binding family member 3 Homo sapiens 117-121 25459884-7 2015 The polyunsaturated fatty acids (PUFAs), particularly long-chain PUFAs (long-chain PUFA-arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid), play an important and beneficial physiologic role in the offspring who receive this fatty acid during critical periods of development. Eicosapentaenoic Acid 106-127 pumilio RNA binding family member 3 Homo sapiens 33-37 25496415-1 2014 BACKGROUND: There is a metabolic pathway by which mammals can convert the omega-3 (n-3) essential fatty acid alpha-linolenic acid (ALA) into longer-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 210-231 pumilio RNA binding family member 3 Homo sapiens 194-198 25496415-1 2014 BACKGROUND: There is a metabolic pathway by which mammals can convert the omega-3 (n-3) essential fatty acid alpha-linolenic acid (ALA) into longer-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 233-236 pumilio RNA binding family member 3 Homo sapiens 194-198 24276408-1 2014 omega-3 polyunsaturated fatty acids (n-3 PUFA), in particular the marine-derived forms eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been demonstrated to affect cancer cell replication, the cell cycle and cell death. Eicosapentaenoic Acid 87-108 pumilio RNA binding family member 3 Homo sapiens 41-45 24832481-1 2014 Omega-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential nutrients for human health. Eicosapentaenoic Acid 72-93 pumilio RNA binding family member 3 Homo sapiens 54-58 24832481-1 2014 Omega-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential nutrients for human health. Eicosapentaenoic Acid 95-98 pumilio RNA binding family member 3 Homo sapiens 54-58 25227179-12 2014 CONCLUSION: Despite the DHA supplement contain very low levels of EPA, E4+ subjects with high EPA at fasting potentially have disrupted postprandial n - 3 PUFA metabolism after receiving a high-dose of DHA. Eicosapentaenoic Acid 94-97 pumilio RNA binding family member 3 Homo sapiens 155-159 24292901-4 2014 Among the tested producers, an isolate named 66 was found to be a potentially high PUFA producer producing relatively high levels of EPA in particular. Eicosapentaenoic Acid 133-136 pumilio RNA binding family member 3 Homo sapiens 83-87 24574493-8 2014 Intake of total fish, fatty fish, and the individual n-3 PUFA eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid also showed U-shaped associations with incident AF. Eicosapentaenoic Acid 62-83 pumilio RNA binding family member 3 Homo sapiens 57-61 24880049-8 2014 RESULTS: LC n-3 PUFA treatment led to a significant increase in EPA (200%) and DHA (23%) in erythrocyte membranes. Eicosapentaenoic Acid 64-67 pumilio RNA binding family member 3 Homo sapiens 16-20 24880049-13 2014 DISCUSSION AND CONCLUSIONS: LC n-3 PUFA supplementation causes a shift in the levels of circulating oxylipins, having the strongest impact on EPA-derived epoxy, dihydroxy and hydroxy FA. Eicosapentaenoic Acid 142-145 pumilio RNA binding family member 3 Homo sapiens 35-39 24597798-4 2014 Blood EPA levels increased and myocardial tissue EPA and DHA levels were significantly higher in n-3 PUFA-treated patients compared with untreated, standard-of-care control patients. Eicosapentaenoic Acid 6-9 pumilio RNA binding family member 3 Homo sapiens 101-105 24597798-4 2014 Blood EPA levels increased and myocardial tissue EPA and DHA levels were significantly higher in n-3 PUFA-treated patients compared with untreated, standard-of-care control patients. Eicosapentaenoic Acid 49-52 pumilio RNA binding family member 3 Homo sapiens 101-105 24276408-1 2014 omega-3 polyunsaturated fatty acids (n-3 PUFA), in particular the marine-derived forms eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been demonstrated to affect cancer cell replication, the cell cycle and cell death. Eicosapentaenoic Acid 110-113 pumilio RNA binding family member 3 Homo sapiens 41-45 24057001-9 2013 Second, we injected mice with an ethyl ester of the PUFA eicosapentaenoic acid and observed an acute decrease in hepatic Hmgcr activity, without alteration in Hmgcr protein abundance. Eicosapentaenoic Acid 57-78 pumilio RNA binding family member 3 Homo sapiens 52-56 23325431-2 2013 In particular, marine n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to possess cardiovascular protective qualities. Eicosapentaenoic Acid 39-60 pumilio RNA binding family member 3 Homo sapiens 26-30 23455698-9 2013 The stability of the produced oil and the complete absence of heavy metals in the bacterial biomass are considered as an additional benefit of bacterial EPA compared to other sources of PUFA. Eicosapentaenoic Acid 153-156 pumilio RNA binding family member 3 Homo sapiens 186-190 23325431-2 2013 In particular, marine n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to possess cardiovascular protective qualities. Eicosapentaenoic Acid 62-65 pumilio RNA binding family member 3 Homo sapiens 26-30 23351824-10 2013 Three-month treatment with n-3 PUFA markedly enriched circulating EPA and DHA, independently of fish intake, and lowered pentraxin-3. Eicosapentaenoic Acid 66-69 pumilio RNA binding family member 3 Homo sapiens 31-35 22095831-5 2012 We found that both DHA and EPA suppress the expression and activity of Delta5- and Delta6-desaturases, leading to decreased flux through the n-3 and n-6 PUFA metabolic pathways and decreased production of AA. Eicosapentaenoic Acid 27-30 pumilio RNA binding family member 3 Homo sapiens 153-157 21826019-10 2013 However, meta-regression analysis showed a trend toward a benefit from n-3 PUFA supplementation when the EPA/DHA ratio was 1:2 (Q model=7.4; p model=0.02) and when preoperative beta-blocker rate was lower (Q model=8.0; p model=0.01). Eicosapentaenoic Acid 105-108 pumilio RNA binding family member 3 Homo sapiens 75-79 23589776-8 2013 Specific n-3 PUFA in fish oil, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) had positive association with high-grade prostate tumor risk only after adjustment of interstudy variability. Eicosapentaenoic Acid 54-57 pumilio RNA binding family member 3 Homo sapiens 13-17 23037902-1 2012 PURPOSE OF REVIEW: Evidence from various research paradigms supports the cardiovascular benefits of a high intake of n-3 polyunsaturated fatty acids (PUFAs), especially the long-chain, marine-derived n-3 PUFA, eicosapentaenoic acids and docosahexaenoic acids. Eicosapentaenoic Acid 210-232 pumilio RNA binding family member 3 Homo sapiens 150-154 22556214-6 2012 When serum from a 6 week clinical intervention with dietary supplements containing olive oil (control), DHA, or two levels of EPA were applied to THP-1 cells, the expression of SCD and FADS2 decreased in the cells treated with serum from the omega3-PUFA-supplemented individuals. Eicosapentaenoic Acid 126-129 pumilio RNA binding family member 3 Homo sapiens 249-253 22326554-4 2012 Chemically, these compounds are hydroxylated derivatives of the parent n-3 PUFA eicosapentaenoic acid (EPA) for the E-resolvins, and docosahexaenoic acid (DHA) for the D-resolvins and protectin D1. Eicosapentaenoic Acid 103-106 pumilio RNA binding family member 3 Homo sapiens 75-79 22095831-7 2012 These results indicate that the fatty acid abnormalities of CF are related to intrinsic alterations of PUFA metabolism and that they may be reversed by supplementation with DHA and EPA. Eicosapentaenoic Acid 181-184 pumilio RNA binding family member 3 Homo sapiens 103-107 21236358-3 2011 Here lipid mediators and metabolites of the n-6 PUFA arachidonic acid as well as the long-chain n-3 PUFA eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA) were measured in human blood samples as well as in mouse blood. Eicosapentaenoic Acid 105-127 pumilio RNA binding family member 3 Homo sapiens 100-104 21605051-6 2011 Second, the relative contribution of two neuroactive n-3 PUFA found in fish oil, docosahexaenoic acid (DHA; 22:6 n-3) and eicosapentaenoic acid (EPA, 20:5 n-3), remains unclear and is reviewed. Eicosapentaenoic Acid 122-143 pumilio RNA binding family member 3 Homo sapiens 57-61 21945097-10 2011 To conclude, the ability of EPA to modify lipid raft physical and chemical properties plays a key role in the enhancement, by this dietary n-3 PUFA, of ethanol-induced oxidative stress. Eicosapentaenoic Acid 28-31 pumilio RNA binding family member 3 Homo sapiens 143-147 20655950-2 2011 Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), each lipid displays unique properties, thus making their role in inflammation distinct from that of other lipids derived from the same PUFA. Eicosapentaenoic Acid 104-107 pumilio RNA binding family member 3 Homo sapiens 42-46 20335550-12 2010 Body mass index and baseline fatty acid concentrations modulated the dose-response effects of omega-3 PUFA supplements on serum EPA and DHA and breast adipose tissue DHA. Eicosapentaenoic Acid 128-131 pumilio RNA binding family member 3 Homo sapiens 102-106 21519759-6 2010 The low rate of coronary disease documented in Eskimos corroborates the cardioprotective effects of the n-3 PUFA eicosapentaenoic (EPA) and docosahexaenoic acids beyond their hypolipemic effects. Eicosapentaenoic Acid 131-134 pumilio RNA binding family member 3 Homo sapiens 108-112 19910654-5 2009 Supplementation with n-3 PUFA resulted in a significant increase in plasma EPA and DHA but had no effect on 10-km time-trial performance; preexercise outcome measures; exercise-induced increases in plasma cytokines, myeloperoxidase, blood total leukocytes, serum C-reactive protein, and creatine kinase; or the decrease in the salivary IgA:protein ratio. Eicosapentaenoic Acid 75-78 pumilio RNA binding family member 3 Homo sapiens 25-29 19427777-1 2010 The long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of fish oil, eicosapentanoic (EPA) and docosahexanoic (DHA) acids are considered cardioprotective. Eicosapentaenoic Acid 91-94 pumilio RNA binding family member 3 Homo sapiens 55-59 19707265-7 2009 This new step in the neutrophil recruitment process was revealed when the dietary n-3-PUFA, eicosapentaenoic acid (EPA), was utilised as an alternative substrate for COX enzymes, leading to the generation of PGD(3). Eicosapentaenoic Acid 92-113 pumilio RNA binding family member 3 Homo sapiens 86-90 19707265-11 2009 Importantly, the ability of the dietary n-3-PUFA, EPA, to inhibit this process not only revealed an unsuspected level of regulation in the migration of inflammatory leukocytes, it also contributes to our understanding of the interactions of this bioactive lipid with the inflammatory system. Eicosapentaenoic Acid 50-53 pumilio RNA binding family member 3 Homo sapiens 44-48 19707265-7 2009 This new step in the neutrophil recruitment process was revealed when the dietary n-3-PUFA, eicosapentaenoic acid (EPA), was utilised as an alternative substrate for COX enzymes, leading to the generation of PGD(3). Eicosapentaenoic Acid 115-118 pumilio RNA binding family member 3 Homo sapiens 86-90 19217322-11 2009 The relative efficacy of EPA suggests that this omega-3 PUFA may be especially useful for dietary supplementation in patients with OA. Eicosapentaenoic Acid 25-28 pumilio RNA binding family member 3 Homo sapiens 56-60 15857162-9 2006 In the n-3 group significantly higher increase was found in n-3 PUFA (eicosapentaenoic acid, 20:5n-3, docosahexaenoic acid, 22:6n-3) in triglycerides and phospholipids. Eicosapentaenoic Acid 70-91 pumilio RNA binding family member 3 Homo sapiens 64-68 18206980-3 2008 By using a panel of 15 human recombinant CYPs, this study demonstrates that other polyunsaturated long-chain fatty acids (PUFA-LC), especially the omega3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are also epoxidised. Eicosapentaenoic Acid 166-187 pumilio RNA binding family member 3 Homo sapiens 122-126 18206980-3 2008 By using a panel of 15 human recombinant CYPs, this study demonstrates that other polyunsaturated long-chain fatty acids (PUFA-LC), especially the omega3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are also epoxidised. Eicosapentaenoic Acid 189-192 pumilio RNA binding family member 3 Homo sapiens 122-126 17623719-1 2007 BACKGROUND: We previously reported that haemodialysis patients have suboptimal blood levels of the cardioprotective omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Eicosapentaenoic Acid 181-184 pumilio RNA binding family member 3 Homo sapiens 157-161 16889775-1 2006 In this study the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n-6 PUFA arachidonic acid is not. Eicosapentaenoic Acid 58-79 pumilio RNA binding family member 3 Homo sapiens 51-55 18504706-1 2008 With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 227-248 pumilio RNA binding family member 3 Homo sapiens 84-88 18504706-1 2008 With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 250-253 pumilio RNA binding family member 3 Homo sapiens 84-88 16784840-3 2007 This study was conducted to evaluate the role of eicosapentaenoic acid (EPA), an n-3 PUFA, in the regulation of Lnk expression in human umbilical vein endothelial cells (HUVECs). Eicosapentaenoic Acid 49-70 pumilio RNA binding family member 3 Homo sapiens 85-89 16784840-3 2007 This study was conducted to evaluate the role of eicosapentaenoic acid (EPA), an n-3 PUFA, in the regulation of Lnk expression in human umbilical vein endothelial cells (HUVECs). Eicosapentaenoic Acid 72-75 pumilio RNA binding family member 3 Homo sapiens 85-89 16140887-7 2005 Arterial blood containing EPA caused significant decreases (P < 0.05) in cAMP, uptake of SFA, monounsaturated fatty acids, and (n-6) PUFA, 13-HODE formation, ERK1/2 phosphorylation, and TTI in MCF-7 xenografts. Eicosapentaenoic Acid 26-29 pumilio RNA binding family member 3 Homo sapiens 136-140 15460168-1 2004 n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), mainly eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), are present in mammal tissues both from endogenous synthesis from desaturation and elongation of 18:3 n-3 and/or from dietary origin (marine products and fish oils). Eicosapentaenoic Acid 65-86 pumilio RNA binding family member 3 Homo sapiens 51-55 15684433-7 2005 Arachidonic and eicosapentaenoic acid both altered DC prostaglandin production, but inhibitors of cyclooxygenases and lipoxygenases did not abolish PUFA effects, indicating that the observed PUFA actions on DCs were independent of autoregulation via eicosanoids. Eicosapentaenoic Acid 16-37 pumilio RNA binding family member 3 Homo sapiens 191-195 15762297-5 2004 Low intakes of fish or of n-3 PUFA in populations have been associated with increased risks of depression and Alzheimer disease, and n-3 PUFA, especially eicosapentaenoic acid (EPA, 20:5n-3), have shown efficacy as adjunctive treatment - and in some cases as the only treatment--in several psychiatric disorders. Eicosapentaenoic Acid 154-175 pumilio RNA binding family member 3 Homo sapiens 137-141 15173404-1 2004 A wealth of evidence indicates that consumption of fish or dietary fish oils containing long-chain (n-3) PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with cardiovascular benefit, including a reduction in circulating triacylglycerol concentrations and reduced mortality from coronary heart disease. Eicosapentaenoic Acid 118-139 pumilio RNA binding family member 3 Homo sapiens 105-109 15173404-1 2004 A wealth of evidence indicates that consumption of fish or dietary fish oils containing long-chain (n-3) PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is associated with cardiovascular benefit, including a reduction in circulating triacylglycerol concentrations and reduced mortality from coronary heart disease. Eicosapentaenoic Acid 141-144 pumilio RNA binding family member 3 Homo sapiens 105-109 15173404-2 2004 Shorter-chain dietary (n-3) PUFA such as alpha-linolenic acid from vegetable oils are inefficiently converted to EPA and DHA and do not possess the hypotriglyceridemic properties attributed to fish oils. Eicosapentaenoic Acid 113-116 pumilio RNA binding family member 3 Homo sapiens 28-32 14733367-3 2003 PUFA constituted 47.6% of the total FA, with the essential PUFA eicosapentaenoic acid (EPA), arachidonic acid, and DHA accounting for 34%. Eicosapentaenoic Acid 64-85 pumilio RNA binding family member 3 Homo sapiens 59-63 34169789-5 2022 Patients treated with immunosuppressants had significantly lower concentrations of LA, arachidonic acid, and EPA.Conclusion: Both n-6 and n-3 PUFA precursors can participate in the inflammatory process in SLE patients. Eicosapentaenoic Acid 109-112 pumilio RNA binding family member 3 Homo sapiens 142-146 34463083-5 2021 The questions remain whether eicosapentaenoic acid is the only PUFA offering cardiovascular benefits, what is the importance of PUFA dosing, and, finally, who should receive n-3 PUFA treatment. Eicosapentaenoic Acid 29-50 pumilio RNA binding family member 3 Homo sapiens 63-67 11497223-3 2001 In the present study, we investigated the suppressive effects of EPA, an n-3 PUFA, on PHA stimulated human peripheral blood T cells. Eicosapentaenoic Acid 65-68 pumilio RNA binding family member 3 Homo sapiens 77-81 8602457-3 1996 This inhibitory effect is PUFA dose-dependent and seems to be more potent with DHA than EPA, Pre-incubation experiments showed that lymphocytes cultured with PUFAs for 6 h then washed and exposed to PHA, still inhibited lymphocyte proliferation. Eicosapentaenoic Acid 88-91 pumilio RNA binding family member 3 Homo sapiens 26-30 1656517-5 1991 Significant increases in platelet and PBMC membrane eicosapentaenoic acid was found in omega-3-PUFA-treated individuals. Eicosapentaenoic Acid 52-73 pumilio RNA binding family member 3 Homo sapiens 87-99 23214138-1 2012 Polyunsaturated fatty acids omega-3 (PUFA omega-3), in particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact signaling pathways involved in the development of cardiovascular diseases. Eicosapentaenoic Acid 84-87 pumilio RNA binding family member 3 Homo sapiens 37-41 23214138-2 2012 PUFA omega-3 affect a myriad of molecular pathways, including alteration physical and chemical properties of membrane microdomains, modulation of membrane receptors and channels, regulation of gene expression via nuclear receptors and transcription factors and changes in eicosanoid clasess" profiles and conversion of EPA and DHA to proresolving mediators. Eicosapentaenoic Acid 319-322 pumilio RNA binding family member 3 Homo sapiens 0-4 34974158-1 2022 Diverse health benefits are associated with dietary consumption of omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 177-198 pumilio RNA binding family member 3 Homo sapiens 126-130 34974158-1 2022 Diverse health benefits are associated with dietary consumption of omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 200-203 pumilio RNA binding family member 3 Homo sapiens 126-130 34214231-1 2022 OBJECTIVE: To evaluate the effects of fish oil (FO), a source of the omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion-generated corticolimbic functional connectivity in depressed youth at high risk for developing bipolar I disorder. Eicosapentaenoic Acid 116-137 pumilio RNA binding family member 3 Homo sapiens 110-114 34262961-6 2021 Research in mammalian and avian models led evidence that perinatal feeding of long chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) engender transgenerational effects through regulation of a variety of biological processes including development of vital organs such as skeleton, brain and GIT. Eicosapentaenoic Acid 106-127 pumilio RNA binding family member 3 Homo sapiens 93-97 34262961-6 2021 Research in mammalian and avian models led evidence that perinatal feeding of long chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) engender transgenerational effects through regulation of a variety of biological processes including development of vital organs such as skeleton, brain and GIT. Eicosapentaenoic Acid 129-132 pumilio RNA binding family member 3 Homo sapiens 93-97 34176006-1 2021 Long-chain (>= C20) polyunsaturated fatty acids (LC-PUFA), such as eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), are necessary for human health and are obtained from marine fish-derived oils. Eicosapentaenoic Acid 67-88 pumilio RNA binding family member 3 Homo sapiens 52-56 34982486-2 2022 OBJECTIVES: To assess changes in EPA and DHA serum concentrations during n-3 PUFA supplementation and their association with incident cardiovascular events. Eicosapentaenoic Acid 33-36 pumilio RNA binding family member 3 Homo sapiens 77-81 35054948-10 2022 CAD patients had significantly lower levels of omega-6 polyunsaturated FAs (n-6 PUFA) and n-3 PUFA, particularly EPA, in the blood. Eicosapentaenoic Acid 113-116 pumilio RNA binding family member 3 Homo sapiens 94-98