PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17217160-0 2006 Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. Eicosapentaenoic Acid 11-32 adiponectin, C1Q and collagen domain containing Rattus norvegicus 42-53 19088251-4 2009 Overnight treatment of rat adipocytes with pioglitazone, docosahexaenoic acid (DHA), or eicosapentaenoic acid (EPA) triggered a twofold increase in the synthesis and secretion of HMW adiponectin, and this increase was blocked by the addition of PPARgamma inhibitor GW-9662. Eicosapentaenoic Acid 88-109 adiponectin, C1Q and collagen domain containing Rattus norvegicus 183-194 19088251-4 2009 Overnight treatment of rat adipocytes with pioglitazone, docosahexaenoic acid (DHA), or eicosapentaenoic acid (EPA) triggered a twofold increase in the synthesis and secretion of HMW adiponectin, and this increase was blocked by the addition of PPARgamma inhibitor GW-9662. Eicosapentaenoic Acid 111-114 adiponectin, C1Q and collagen domain containing Rattus norvegicus 183-194 19088251-5 2009 Inhibition of glycosylation using 2,2"-dipyridyl decreased the synthesis of high-molecular weight adiponectin by pioglitazone, EPA, and DHA, but there was increased secretion of trimeric adiponectin resulting from increased translation. Eicosapentaenoic Acid 127-130 adiponectin, C1Q and collagen domain containing Rattus norvegicus 98-109 19088251-6 2009 Although pioglitazone, DHA, and EPA increased adiponectin synthesis by more than 60%, there was no increase in total protein synthesis and no corresponding change in adiponectin mRNA expression, indicating the upregulation of translation. Eicosapentaenoic Acid 32-35 adiponectin, C1Q and collagen domain containing Rattus norvegicus 46-57 19088251-10 2009 Together, these data suggest that pioglitazone and the fish oils DHA or EPA are PPARgamma agonists in adipocytes with regard to adiponectin expression, and the predominant mode of adiponectin stimulation is via an increase in translation. Eicosapentaenoic Acid 72-75 adiponectin, C1Q and collagen domain containing Rattus norvegicus 128-139 19088251-10 2009 Together, these data suggest that pioglitazone and the fish oils DHA or EPA are PPARgamma agonists in adipocytes with regard to adiponectin expression, and the predominant mode of adiponectin stimulation is via an increase in translation. Eicosapentaenoic Acid 72-75 adiponectin, C1Q and collagen domain containing Rattus norvegicus 180-191 17217160-0 2006 Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. Eicosapentaenoic Acid 34-37 adiponectin, C1Q and collagen domain containing Rattus norvegicus 42-53 17217160-3 2006 Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesity and diabetes, which has been suggested to be related to adiponectin induction. Eicosapentaenoic Acid 0-21 adiponectin, C1Q and collagen domain containing Rattus norvegicus 191-202 17217160-3 2006 Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesity and diabetes, which has been suggested to be related to adiponectin induction. Eicosapentaenoic Acid 23-26 adiponectin, C1Q and collagen domain containing Rattus norvegicus 191-202 17217160-5 2006 The aim of this trial was to evaluate the direct effects of EPA on adiponectin gene expression and protein secretion in isolated rat adipocytes as well as to explore the potential mechanisms involved. Eicosapentaenoic Acid 60-63 adiponectin, C1Q and collagen domain containing Rattus norvegicus 67-78 17217160-10 2006 However, EPA significantly decreased adiponectin gene expression and protein secretion and reduced PPARy mRNA levels, suggesting that the inhibition of adiponectin by EPA is likely to be secondary to the down-regulation of this adipogenic transcription factor. Eicosapentaenoic Acid 9-12 adiponectin, C1Q and collagen domain containing Rattus norvegicus 37-48 17217160-10 2006 However, EPA significantly decreased adiponectin gene expression and protein secretion and reduced PPARy mRNA levels, suggesting that the inhibition of adiponectin by EPA is likely to be secondary to the down-regulation of this adipogenic transcription factor. Eicosapentaenoic Acid 9-12 adiponectin, C1Q and collagen domain containing Rattus norvegicus 152-163 17217160-11 2006 Moreover, these results suggest that other mechanisms different from the direct stimulation of adiponectin by the fatty acid are underlying the insulin-sensitizing properties observed after EPA treatment in vivo. Eicosapentaenoic Acid 190-193 adiponectin, C1Q and collagen domain containing Rattus norvegicus 95-106 27708849-8 2016 Moreover, EPA increased circulating levels of adiponectin as well as attenuated both the down-regulation of AMP-activated protein kinase phosphorylation and the up-regulation of phosphorylation of the p65 subunit of nuclear factor-kB in the heart of DS/obese rats. Eicosapentaenoic Acid 10-13 adiponectin, C1Q and collagen domain containing Rattus norvegicus 46-57 27708849-9 2016 CONCLUSIONS: Treatment of DS/obese rats with EPA did not affect hypertension but reduced cardiac fibrosis and diastolic dysfunction, with the latter effects being accompanied by AMP-activated protein kinase activation and inactivation of nuclear factor-kB signalling in the heart, possibly as a result of an increase in adiponectin secretion. Eicosapentaenoic Acid 45-48 adiponectin, C1Q and collagen domain containing Rattus norvegicus 320-331