PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25697344-5 2015 Promoter deletion analysis and chromatin immunoprecipitation assay revealed that co-transfection of GPR120 enhanced EPA-induced PPARgamma binding to PPAR-response element in VEGF-A promoter region. Eicosapentaenoic Acid 116-119 peroxisome proliferator activated receptor alpha Homo sapiens 128-132 21274596-6 2011 The results showed that the expression of the PPAR-alpha, ACOX, and LPL genes increased significantly following LA and EPA exposure, but that the expression of L-FABP remained unchanged. Eicosapentaenoic Acid 119-122 peroxisome proliferator activated receptor alpha Homo sapiens 46-56 25255786-8 2014 Arachidonic, eicosapentaenoic acid, and docosahexaenoic acid all activated PPARalpha transactivation at lower doses, but acted at higher concentrations as PPARalpha repressors. Eicosapentaenoic Acid 13-34 peroxisome proliferator activated receptor alpha Homo sapiens 75-84 25255786-8 2014 Arachidonic, eicosapentaenoic acid, and docosahexaenoic acid all activated PPARalpha transactivation at lower doses, but acted at higher concentrations as PPARalpha repressors. Eicosapentaenoic Acid 13-34 peroxisome proliferator activated receptor alpha Homo sapiens 155-164 24396573-9 2013 DISCUSSIONS: In comparison to the control of Wy14643, Sandoz58-035, c9 and t11-CLA, EPA increased the PPARalpha mRNA levels (P = 0.024, P = 0.041, P = 0.043, and P = 0.004, respectively), even though, LA had no significant effect on the PPARalpha mRNA expression (P = 0.489). Eicosapentaenoic Acid 84-87 peroxisome proliferator activated receptor alpha Homo sapiens 102-111 24396573-9 2013 DISCUSSIONS: In comparison to the control of Wy14643, Sandoz58-035, c9 and t11-CLA, EPA increased the PPARalpha mRNA levels (P = 0.024, P = 0.041, P = 0.043, and P = 0.004, respectively), even though, LA had no significant effect on the PPARalpha mRNA expression (P = 0.489). Eicosapentaenoic Acid 84-87 peroxisome proliferator activated receptor alpha Homo sapiens 237-246 23497599-0 2012 Effects of EPA supplementation on plasma fatty acids composition in hypertriglyceridemic subjects with FABP2 and PPARalpha genotypes. Eicosapentaenoic Acid 11-14 peroxisome proliferator activated receptor alpha Homo sapiens 113-122 23497599-2 2012 Polymorphism of FABP2 and PPARalpha may influence plasma levels of fatty acids in those who take supplemental eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 110-131 peroxisome proliferator activated receptor alpha Homo sapiens 26-35 23497599-2 2012 Polymorphism of FABP2 and PPARalpha may influence plasma levels of fatty acids in those who take supplemental eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 133-136 peroxisome proliferator activated receptor alpha Homo sapiens 26-35 23497599-3 2012 The purpose of this study was to study the potential associations between the Ala54/Thr polymorphism in FABP2 protein and the Leu162/Val in exon 5 and G/C in intron 7 of PPARalpha with plasma fatty acids composition after EPA supplementation. Eicosapentaenoic Acid 222-225 peroxisome proliferator activated receptor alpha Homo sapiens 170-179 23497599-7 2012 RESULTS: Although EPA supplementation increased the level of plasma EPA and omega-3 fatty acids in both carriers of FABP2 and PPARalpha genes, these effects were more pronounced in Thr54 and Val162 carriers. Eicosapentaenoic Acid 18-21 peroxisome proliferator activated receptor alpha Homo sapiens 126-135 23497599-7 2012 RESULTS: Although EPA supplementation increased the level of plasma EPA and omega-3 fatty acids in both carriers of FABP2 and PPARalpha genes, these effects were more pronounced in Thr54 and Val162 carriers. Eicosapentaenoic Acid 68-71 peroxisome proliferator activated receptor alpha Homo sapiens 126-135 24396573-4 2013 Alpha Linolenic Acid (LA), and Eicosapentaenoic Acid (EPA) on the PPARalpha and ACAT1 mRNA expression by Real time PCR and cholesterol homeostasis in THP-1 macrophages derived foam cells. Eicosapentaenoic Acid 31-52 peroxisome proliferator activated receptor alpha Homo sapiens 66-75 24396573-4 2013 Alpha Linolenic Acid (LA), and Eicosapentaenoic Acid (EPA) on the PPARalpha and ACAT1 mRNA expression by Real time PCR and cholesterol homeostasis in THP-1 macrophages derived foam cells. Eicosapentaenoic Acid 54-57 peroxisome proliferator activated receptor alpha Homo sapiens 66-75 21274596-7 2011 This study provides the first characterization of LA- and EPA-induced cell proliferation and PPAR-alpha and PPAR-alpha target gene transcriptional responses in duck primary hepatocyte cultures. Eicosapentaenoic Acid 58-61 peroxisome proliferator activated receptor alpha Homo sapiens 93-103 21274596-7 2011 This study provides the first characterization of LA- and EPA-induced cell proliferation and PPAR-alpha and PPAR-alpha target gene transcriptional responses in duck primary hepatocyte cultures. Eicosapentaenoic Acid 58-61 peroxisome proliferator activated receptor alpha Homo sapiens 108-118 19944311-4 2009 EPA-induced CYP 2J2 expression was significantly inhibited by pretreatment with a peroxisome proliferator-activated receptor (PPAR) gamma antagonist, GW9662. Eicosapentaenoic Acid 0-3 peroxisome proliferator activated receptor alpha Homo sapiens 82-124 19944311-4 2009 EPA-induced CYP 2J2 expression was significantly inhibited by pretreatment with a peroxisome proliferator-activated receptor (PPAR) gamma antagonist, GW9662. Eicosapentaenoic Acid 0-3 peroxisome proliferator activated receptor alpha Homo sapiens 126-130 18762411-5 2008 In addition, peroxisome proliferator-activated receptor (PPAR) gamma antagonists abolished the inhibitory effect of EPA on IL-1beta-induced IL-6 production, whereas PPARalpha antagonist did not block the inhibitory effect of EPA. Eicosapentaenoic Acid 116-119 peroxisome proliferator activated receptor alpha Homo sapiens 13-55 19266045-2 2009 It is hypothesized that the transcriptional activity by wild-type L162-PPARalpha is enhanced to a greater extent than the mutated variant (V162-PPARalpha) in the presence of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) or a mixture of EPA:DHA. Eicosapentaenoic Acid 174-195 peroxisome proliferator activated receptor alpha Homo sapiens 71-80 19266045-2 2009 It is hypothesized that the transcriptional activity by wild-type L162-PPARalpha is enhanced to a greater extent than the mutated variant (V162-PPARalpha) in the presence of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) or a mixture of EPA:DHA. Eicosapentaenoic Acid 197-200 peroxisome proliferator activated receptor alpha Homo sapiens 71-80 19266045-2 2009 It is hypothesized that the transcriptional activity by wild-type L162-PPARalpha is enhanced to a greater extent than the mutated variant (V162-PPARalpha) in the presence of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) or a mixture of EPA:DHA. Eicosapentaenoic Acid 246-249 peroxisome proliferator activated receptor alpha Homo sapiens 71-80 19266045-4 2009 Results indicate that the addition of EPA or DHA demonstrate potential to increase the transcriptional activity by PPARalpha with respect to basal level in both variants. Eicosapentaenoic Acid 38-41 peroxisome proliferator activated receptor alpha Homo sapiens 115-124 19266045-6 2009 Additionally, the V162 allelic form of PPARalpha demonstrated consistently lower transcriptional activation when incubated with EPA, DHA or EPA:DHA mixtures than, the wild-type variant. Eicosapentaenoic Acid 128-131 peroxisome proliferator activated receptor alpha Homo sapiens 39-48 19266045-6 2009 Additionally, the V162 allelic form of PPARalpha demonstrated consistently lower transcriptional activation when incubated with EPA, DHA or EPA:DHA mixtures than, the wild-type variant. Eicosapentaenoic Acid 140-143 peroxisome proliferator activated receptor alpha Homo sapiens 39-48 19725980-5 2009 METHODS: This study examined effects of c9, t11-conjugated linoleic acid(c9, t11-CLA), alpha linolenic acid (LA), eicosapentaenoic acid (EPA) on the PPARalpha and ACAT1 genes expression by using Real time PCR and cholesterol homeostasis in THP-1 macrophages derived foam cells. Eicosapentaenoic Acid 114-135 peroxisome proliferator activated receptor alpha Homo sapiens 149-158 19725980-8 2009 Treatment with EPA increased PPARalpha mRNA levels (P < or = 0.001), although CLA, LA had no significant effect on PPARalpha mRNA expression. Eicosapentaenoic Acid 15-18 peroxisome proliferator activated receptor alpha Homo sapiens 29-38 19585164-5 2009 Data demonstrates that gene expression levels of PPARalpha and apolipoprotein AI (APOA1) were significantly lower for carriers of the PPARalpha-V162 allele compared to L162 homozygotes after the addition of DHA and a mixture of EPA:DHA. Eicosapentaenoic Acid 228-231 peroxisome proliferator activated receptor alpha Homo sapiens 49-58 19585164-5 2009 Data demonstrates that gene expression levels of PPARalpha and apolipoprotein AI (APOA1) were significantly lower for carriers of the PPARalpha-V162 allele compared to L162 homozygotes after the addition of DHA and a mixture of EPA:DHA. Eicosapentaenoic Acid 228-231 peroxisome proliferator activated receptor alpha Homo sapiens 134-143 19585164-6 2009 Additionally, lipoprotein lipase (LPL) gene expression displayed a tendency to be lower in the PPARalpha L162V polymorphism subgroup after the addition of a mixture of EPA:DHA. Eicosapentaenoic Acid 168-171 peroxisome proliferator activated receptor alpha Homo sapiens 95-104 18762411-5 2008 In addition, peroxisome proliferator-activated receptor (PPAR) gamma antagonists abolished the inhibitory effect of EPA on IL-1beta-induced IL-6 production, whereas PPARalpha antagonist did not block the inhibitory effect of EPA. Eicosapentaenoic Acid 116-119 peroxisome proliferator activated receptor alpha Homo sapiens 57-61 9610365-7 1998 In addition, PPAR alpha expression was also increased by benzafibrate or eicosapentaenoic acid with the physiological concentration. Eicosapentaenoic Acid 73-94 peroxisome proliferator activated receptor alpha Homo sapiens 13-23 18203887-3 2008 At nutritionally relevant concentrations, EPA stimulated a PPAR response element (PPRE) reporter assay in a dose-responsive manner in HT-29 cells. Eicosapentaenoic Acid 42-45 peroxisome proliferator activated receptor alpha Homo sapiens 59-63 26577021-6 2016 Further, EPA also induced the expression of carnitine palmitoyl transferase 1A (CPT1A) expression, a PPARalpha target gene. Eicosapentaenoic Acid 9-12 peroxisome proliferator activated receptor alpha Homo sapiens 101-110 26577021-9 2016 These results suggest that EPA inhibits intestinal beta-carotene absorption by down regulation of SR B1 expression via PPARalpha dependent mechanism and provide an evidence for dietary modulation of intestinal beta-carotene absorption. Eicosapentaenoic Acid 27-30 peroxisome proliferator activated receptor alpha Homo sapiens 119-128 32360782-1 2020 PURPOSE: The purpose of this study was to access the ability of the natural PPAR agonist, eicosapentaenoic acid (EPA), to activate PPAR gamma (gamma) signaling leading to meibocyte differentiation in human meibomian gland epithelial cell (hMGEC). Eicosapentaenoic Acid 90-111 peroxisome proliferator activated receptor alpha Homo sapiens 76-80 32360782-1 2020 PURPOSE: The purpose of this study was to access the ability of the natural PPAR agonist, eicosapentaenoic acid (EPA), to activate PPAR gamma (gamma) signaling leading to meibocyte differentiation in human meibomian gland epithelial cell (hMGEC). Eicosapentaenoic Acid 113-116 peroxisome proliferator activated receptor alpha Homo sapiens 76-80 26577021-0 2016 Eicosapentaenoic acid inhibits intestinal beta-carotene absorption by downregulation of lipid transporter expression via PPAR-alpha dependent mechanism. Eicosapentaenoic Acid 0-21 peroxisome proliferator activated receptor alpha Homo sapiens 121-131