PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26187667-5 2015 Moreover, the ingestion of EPA significantly decreased the expression of hepatic peroxisome sterol regulatory element-binding protein (SREBP1c), carbohydrate response element-binding protein (ChREBP), stearoyl-CoA deaturase and periostin, which are involved in hepatic lipogenesis and hepatosteaotosis, in KKA(y) mice. Eicosapentaenoic Acid 27-30 sterol regulatory element binding transcription factor 1 Mus musculus 135-142 33164545-0 2020 Eicosapentaenoic acid reduces inflammation and apoptosis by SREBP1/TLR4/MYD88. Eicosapentaenoic Acid 0-21 sterol regulatory element binding transcription factor 1 Mus musculus 60-66 33164545-7 2020 In addition, overexpression of the sterol regulatory element-binding protein-1 (SREBP-1) reversed the protective effects of EPA in high glucose-treated podocytes. Eicosapentaenoic Acid 124-127 sterol regulatory element binding transcription factor 1 Mus musculus 35-78 33164545-7 2020 In addition, overexpression of the sterol regulatory element-binding protein-1 (SREBP-1) reversed the protective effects of EPA in high glucose-treated podocytes. Eicosapentaenoic Acid 124-127 sterol regulatory element binding transcription factor 1 Mus musculus 80-87 33164545-8 2020 EPA inhibits the SREBP-1/TLR4/MYD88 signaling in high glucose treated cells. Eicosapentaenoic Acid 0-3 sterol regulatory element binding transcription factor 1 Mus musculus 17-24 33164545-9 2020 CONCLUSIONS: This study suggests that EPA protects against podocytes dysfunction by regulating SREBP-1 and these findings provide a better understanding for diabetic nephropathy and a novel therapeutic strategy (Fig. Eicosapentaenoic Acid 38-41 sterol regulatory element binding transcription factor 1 Mus musculus 95-102 20691165-0 2010 Eicosapentaenoic acid improves hepatic steatosis independent of PPARalpha activation through inhibition of SREBP-1 maturation in mice. Eicosapentaenoic Acid 0-21 sterol regulatory element binding transcription factor 1 Mus musculus 107-114 24729033-6 2014 The nuclear form of the mutant SREBP-1c was induced by delipidated condition and suppressed by eicosapentaenoic acid, an n-3 PUFA, but not by sterols. Eicosapentaenoic Acid 95-116 sterol regulatory element binding transcription factor 1 Mus musculus 31-39 20691165-7 2010 Instead, EPA inhibited maturation of sterol-responsive element-binding protein (SREBP)-1 in the presence of PPARalpha through down-regulation of SREBP cleavage-activating protein and site-1 protease. Eicosapentaenoic Acid 9-12 sterol regulatory element binding transcription factor 1 Mus musculus 37-88 18458149-6 2008 Concomitantly, palmitate activated and EPA abolished both mRNA and nuclear protein of SREBP-1c, accompanied by reciprocal changes of SREBP-1c target genes such as insulin receptor substrate-2 (IRS-2) and granuphilin. Eicosapentaenoic Acid 39-42 sterol regulatory element binding transcription factor 1 Mus musculus 86-94 20542418-8 2010 These findings indicate that Cide-a and Cide-c are closely involved in the progression of hepatic steatosis, and that EPA inhibits Cide-a gene expression through SREBP-1 regulation. Eicosapentaenoic Acid 118-121 sterol regulatory element binding transcription factor 1 Mus musculus 162-169 19416647-8 2009 When eicosapentaenoic acid (EPA), a suppressor of sterol regulatory element binding protein 1 (SREBP-1), was administered to HFHSD-fed mice, the sensitivity of DGalN, as a result of plasma ALT and AST levels, was suppressed accompanied by reduced plasma sTNFR2 level and hepatic levels of triglyceride, ROS, and fibrogenic parameters, and by increased plasma adiponectin levels. Eicosapentaenoic Acid 5-26 sterol regulatory element binding transcription factor 1 Mus musculus 50-93 19416647-8 2009 When eicosapentaenoic acid (EPA), a suppressor of sterol regulatory element binding protein 1 (SREBP-1), was administered to HFHSD-fed mice, the sensitivity of DGalN, as a result of plasma ALT and AST levels, was suppressed accompanied by reduced plasma sTNFR2 level and hepatic levels of triglyceride, ROS, and fibrogenic parameters, and by increased plasma adiponectin levels. Eicosapentaenoic Acid 5-26 sterol regulatory element binding transcription factor 1 Mus musculus 95-102 19416647-8 2009 When eicosapentaenoic acid (EPA), a suppressor of sterol regulatory element binding protein 1 (SREBP-1), was administered to HFHSD-fed mice, the sensitivity of DGalN, as a result of plasma ALT and AST levels, was suppressed accompanied by reduced plasma sTNFR2 level and hepatic levels of triglyceride, ROS, and fibrogenic parameters, and by increased plasma adiponectin levels. Eicosapentaenoic Acid 28-31 sterol regulatory element binding transcription factor 1 Mus musculus 50-93 19416647-8 2009 When eicosapentaenoic acid (EPA), a suppressor of sterol regulatory element binding protein 1 (SREBP-1), was administered to HFHSD-fed mice, the sensitivity of DGalN, as a result of plasma ALT and AST levels, was suppressed accompanied by reduced plasma sTNFR2 level and hepatic levels of triglyceride, ROS, and fibrogenic parameters, and by increased plasma adiponectin levels. Eicosapentaenoic Acid 28-31 sterol regulatory element binding transcription factor 1 Mus musculus 95-102 19328666-8 2009 EPA also decreased the hepatic mRNA expression and nuclear protein level of sterol regulatory element binding protein-1c (SREBP-1c). Eicosapentaenoic Acid 0-3 sterol regulatory element binding transcription factor 1 Mus musculus 76-120 19328666-8 2009 EPA also decreased the hepatic mRNA expression and nuclear protein level of sterol regulatory element binding protein-1c (SREBP-1c). Eicosapentaenoic Acid 0-3 sterol regulatory element binding transcription factor 1 Mus musculus 122-130 19328666-10 2009 In conclusion, oral administration of EPA-E ameliorates hepatic fat accumulation by suppressing TG synthesis enzymes regulated by SREBP-1 and decreases hepatic MUFAs accumulation by SCD1. Eicosapentaenoic Acid 38-41 sterol regulatory element binding transcription factor 1 Mus musculus 130-137 19162361-8 2009 RESULTS: EPA-ameliorated hepatic steatosis in Pten-deficient mice was based on decreased expression of AMPKalpha1-mediated SREBP-1c and increased PPARalpha expression. Eicosapentaenoic Acid 9-12 sterol regulatory element binding transcription factor 1 Mus musculus 123-131 18458149-12 2008 CONCLUSIONS: SREBP-1c plays a dominant role in palmitate-mediated insulin secretion defect, and EPA prevents it through SREBP-1c inhibition, implicating a therapeutic potential for treating diabetes related to lipotoxicity. Eicosapentaenoic Acid 96-99 sterol regulatory element binding transcription factor 1 Mus musculus 120-128 17919187-7 2007 Saturated fatty acids, such as palmitic acid (PA), impair insulin secretion through SREBP-1c activation, whereas polyunsaturated fatty acids including eicosapentaenoic acid (EPA) restore PA-suppressed insulin secretion through suppression of SREBP-1c. Eicosapentaenoic Acid 151-172 sterol regulatory element binding transcription factor 1 Mus musculus 242-250 16112614-6 2005 Luciferase assay using mutation of LXREs in mouse primary hepatocytes revealed that the LXR ligand, T0901317, induced increased transcription of SREBP-1c mRNA was mediated by LXREs, but it is unknown whether fish oil/eicosapentaenoic acid (EPA)-induced down-regulation of SREBP-1c mRNA was mediated by LXREs. Eicosapentaenoic Acid 217-238 sterol regulatory element binding transcription factor 1 Mus musculus 145-153 16112614-6 2005 Luciferase assay using mutation of LXREs in mouse primary hepatocytes revealed that the LXR ligand, T0901317, induced increased transcription of SREBP-1c mRNA was mediated by LXREs, but it is unknown whether fish oil/eicosapentaenoic acid (EPA)-induced down-regulation of SREBP-1c mRNA was mediated by LXREs. Eicosapentaenoic Acid 240-243 sterol regulatory element binding transcription factor 1 Mus musculus 145-153