PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30968772-4 2020 RESULT: The LCPUFAs eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n- 3, DHA) have a positive effect in diminishing liver steatosis, OS, and the levels of aspartate aminotransferase, alanine aminotransferase and pro-inflammatory cytokines, with improvement of insulin sensitivity and adiponectin levels. Eicosapentaenoic Acid 20-41 adiponectin, C1Q and collagen domain containing Homo sapiens 308-319 33482602-3 2021 While some studies have shown that marine-derived omega-3 fatty acids (eicosapentaenoic acid [EPA] and/or docosahexaenoic acid [DHA]) have effects on leptin and adiponectin in the context of inflammation, the extent of their effects remain unclear. Eicosapentaenoic Acid 71-92 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 33482602-3 2021 While some studies have shown that marine-derived omega-3 fatty acids (eicosapentaenoic acid [EPA] and/or docosahexaenoic acid [DHA]) have effects on leptin and adiponectin in the context of inflammation, the extent of their effects remain unclear. Eicosapentaenoic Acid 94-97 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 33482602-4 2021 The purpose of this systematic review was to summarize findings from randomized, controlled trials that measured effects of EPA+DHA supplementation on circulating levels of leptin and adiponectin to determine the state of the science. Eicosapentaenoic Acid 124-127 adiponectin, C1Q and collagen domain containing Homo sapiens 184-195 33482602-7 2021 Eighteen studies reported lower leptin and/or higher adiponectin levels with EPA+DHA supplementation versus placebo at study end point (9 reported statistically significant differences), but doses, supplementation duration, and population characteristics varied across studies. Eicosapentaenoic Acid 77-80 adiponectin, C1Q and collagen domain containing Homo sapiens 53-64 29676540-11 2018 CONCLUSION: Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-alpha levels in this population group. Eicosapentaenoic Acid 12-33 adiponectin, C1Q and collagen domain containing Homo sapiens 88-99 27281302-5 2016 RESULTS: Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% +- 2.8% compared with -0.5% +- 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% +- 1.6% compared with -1.2% +- 1.7%, respectively; P < 0.001). Eicosapentaenoic Acid 69-72 adiponectin, C1Q and collagen domain containing Homo sapiens 220-231 28811832-2 2017 Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to increase adiponectin by previous studies using a mixture of them. Eicosapentaenoic Acid 31-52 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 28811832-2 2017 Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to increase adiponectin by previous studies using a mixture of them. Eicosapentaenoic Acid 54-57 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 28811832-4 2017 In the present study, we observed and compared the individual effect of DHA and EPA on adiponectin in 3T3-L1 adipocytes, and further tested whether DHA or EPA regulated adiponectin by peroxisome proliferator-activated receptor gamma (PPARgamma) and its phosphorylation at Ser273 to provide a plausible explanation for their distinct actions. Eicosapentaenoic Acid 80-83 adiponectin, C1Q and collagen domain containing Homo sapiens 87-98 28811832-9 2017 Adiponectin expressions in DHA treated groups were significantly higher than those in EPA treated groups at 50 and 100 mumol/L. Eicosapentaenoic Acid 86-89 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 28811832-11 2017 GW9662 blocked DHA- and EPA-induced increases in PPARgamma as well as adiponectin. Eicosapentaenoic Acid 24-27 adiponectin, C1Q and collagen domain containing Homo sapiens 70-81 28811832-15 2017 CONCLUSION: DHA compared with EPA led to a greater increase in cellular and secreted adiponectin at relative low concentrations by increasing PPARgamma expression and inhibiting its phosphorylation at Ser273. Eicosapentaenoic Acid 30-33 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 25816805-6 2015 Furthermore, adiponectin was inversely correlated to the plasma levels of the two major n-3 PUFA docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) (r = -0.19, p < 0.001, and r = -0.30, p < 0.001, respectively). Eicosapentaenoic Acid 128-149 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Eicosapentaenoic Acid 77-98 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25900100-4 2015 Adiponectin secretion was increased by treatment with fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Eicosapentaenoic Acid 100-103 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 25816805-6 2015 Furthermore, adiponectin was inversely correlated to the plasma levels of the two major n-3 PUFA docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) (r = -0.19, p < 0.001, and r = -0.30, p < 0.001, respectively). Eicosapentaenoic Acid 151-154 adiponectin, C1Q and collagen domain containing Homo sapiens 13-24 25816805-9 2015 CONCLUSION: We found an elevated plasma adiponectin level, which was inversely associated with plasma levels of DHA and EPA at baseline. Eicosapentaenoic Acid 120-123 adiponectin, C1Q and collagen domain containing Homo sapiens 40-51 25629558-8 2015 Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and DHA combined with arachidonic acid (ARA) upregulated adiponectin secretion. Eicosapentaenoic Acid 0-21 adiponectin, C1Q and collagen domain containing Homo sapiens 114-125 25629558-8 2015 Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and DHA combined with arachidonic acid (ARA) upregulated adiponectin secretion. Eicosapentaenoic Acid 23-26 adiponectin, C1Q and collagen domain containing Homo sapiens 114-125 25213455-8 2014 GxE variance of the arachidonic acid/eicosapentaenoic acid ratio showed a marginally significant contribution to the adiponectin variance (16.0%, P-nominal = 0.058). Eicosapentaenoic Acid 37-58 adiponectin, C1Q and collagen domain containing Homo sapiens 117-128 25519029-5 2014 In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p<0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p<0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p<0.05). Eicosapentaenoic Acid 36-39 adiponectin, C1Q and collagen domain containing Homo sapiens 86-97 25519029-8 2014 We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels. Eicosapentaenoic Acid 16-19 adiponectin, C1Q and collagen domain containing Homo sapiens 183-194 19403992-5 2009 In contrast, all markers except for adiponectin were decreased significantly in diabetic patients with high Ang-2 levels after 6 months of EPA treatment. Eicosapentaenoic Acid 139-142 adiponectin, C1Q and collagen domain containing Homo sapiens 36-47 23351824-6 2013 Baseline eicosapentaenoic acid (EPA) but not docosahexaenoic acid (DHA) was inversely related to C-reactive protein, pentraxin-3, adiponectin, natriuretic peptide, and troponin levels. Eicosapentaenoic Acid 9-30 adiponectin, C1Q and collagen domain containing Homo sapiens 130-141 23351824-6 2013 Baseline eicosapentaenoic acid (EPA) but not docosahexaenoic acid (DHA) was inversely related to C-reactive protein, pentraxin-3, adiponectin, natriuretic peptide, and troponin levels. Eicosapentaenoic Acid 32-35 adiponectin, C1Q and collagen domain containing Homo sapiens 130-141 20814411-0 2011 Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARgamma-dependent manner in human adipocytes. Eicosapentaenoic Acid 0-21 adiponectin, C1Q and collagen domain containing Homo sapiens 49-60 18579237-5 2009 In men, serum adiponectin correlated to levels of the content of EPA in platelets (r=0.26; p<0.01) and in granulocytes (r=0.23; p<0.01) and to the content of DHA in subcutaneous adipose tissue (r=0.15; p<0.05) and granulocytes (r=0.17; p<0.05). Eicosapentaenoic Acid 65-68 adiponectin, C1Q and collagen domain containing Homo sapiens 14-25 18579237-8 2009 Also, intake of EPA may increase serum adiponectin and through this exert a protective effect on CHD. Eicosapentaenoic Acid 16-19 adiponectin, C1Q and collagen domain containing Homo sapiens 39-50 24332315-3 2014 DHA compared to EPA treatment led to a greater increase in adiponectin secretion and, conditioned media collected from DHA treated cells inhibited monocyte migration. Eicosapentaenoic Acid 16-19 adiponectin, C1Q and collagen domain containing Homo sapiens 59-70 22912426-9 2012 Only increases in monocyte IL-10 expression and serum adiponectin were independent determinants of a decreased PWV by EPA. Eicosapentaenoic Acid 118-121 adiponectin, C1Q and collagen domain containing Homo sapiens 54-65 22460550-9 2012 The AA/EPA ratio was negatively associated with adiponectin concentrations in plasma and subcutaneous abdominal AT (0.01 < p < 0.05). Eicosapentaenoic Acid 7-10 adiponectin, C1Q and collagen domain containing Homo sapiens 48-59 21164549-2 2010 Long-chain n-3 fatty acids eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA) may be involved in adiponectin regulation as they are potential ligands for peroxisome proliferator-activated receptor-gamma (PPARgamma), a key transcription factor for the adiponectin gene. Eicosapentaenoic Acid 27-48 adiponectin, C1Q and collagen domain containing Homo sapiens 123-134 21164549-2 2010 Long-chain n-3 fatty acids eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA) may be involved in adiponectin regulation as they are potential ligands for peroxisome proliferator-activated receptor-gamma (PPARgamma), a key transcription factor for the adiponectin gene. Eicosapentaenoic Acid 27-48 adiponectin, C1Q and collagen domain containing Homo sapiens 277-288 19763135-6 2009 EPA treatment significantly reduced the levels of immunoreactive insulin, triglycerides, SAA-LDL, CRP, PWV and CAVI and increased the levels of adiponectin relative to the control group for 3 months (P<0.05). Eicosapentaenoic Acid 0-3 adiponectin, C1Q and collagen domain containing Homo sapiens 144-155 19403992-6 2009 These diabetic patients with high Ang-2 levels displayed a more significant increase in adiponectin levels after EPA treatment than those who did not. Eicosapentaenoic Acid 113-116 adiponectin, C1Q and collagen domain containing Homo sapiens 88-99 19403992-7 2009 CONCLUSION: These results suggest that EPA possesses an adiponectin-dependent anti-atherosclerotic effect and may be beneficial for the prevention of vascular complications in diabetic patients with high Ang-2 levels. Eicosapentaenoic Acid 39-42 adiponectin, C1Q and collagen domain containing Homo sapiens 56-67 19172517-2 2009 However, the influence of EPA and statins on PDMP and adiponectin in atherosclerosis is poorly understood. Eicosapentaenoic Acid 26-29 adiponectin, C1Q and collagen domain containing Homo sapiens 54-65 19172517-3 2009 We investigated the effect of pitavastatin and EPA on circulating levels of PDMP and adiponectin in hyperlipidemic patients with type II diabetes. Eicosapentaenoic Acid 47-50 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 17569885-0 2007 Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Eicosapentaenoic Acid 51-72 adiponectin, C1Q and collagen domain containing Homo sapiens 10-21 17569885-2 2007 Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. Eicosapentaenoic Acid 51-72 adiponectin, C1Q and collagen domain containing Homo sapiens 96-107 17569885-2 2007 Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. Eicosapentaenoic Acid 74-77 adiponectin, C1Q and collagen domain containing Homo sapiens 96-107 17569885-4 2007 In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-alpha in macrophages. Eicosapentaenoic Acid 57-60 adiponectin, C1Q and collagen domain containing Homo sapiens 104-115 17569885-5 2007 We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Eicosapentaenoic Acid 128-131 adiponectin, C1Q and collagen domain containing Homo sapiens 46-57 17569885-6 2007 Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. Eicosapentaenoic Acid 47-50 adiponectin, C1Q and collagen domain containing Homo sapiens 107-118 17569885-7 2007 CONCLUSION: This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Eicosapentaenoic Acid 41-44 adiponectin, C1Q and collagen domain containing Homo sapiens 55-66