PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26381084-4 2015 It was found that both EPA and DHA in the concentration-dependent manner suppressed the cell viability, enhanced cell death, induced activation of caspase-3/7 and potentiated intracellular oxidative DNA and protein damage. Eicosapentaenoic Acid 23-26 caspase 3 Homo sapiens 147-156 28920465-0 2018 Fish-oil-derived eicosapentaenoic acid decreases survivin expression and induces wt-p53 accumulation with caspase-3 activation in acute lymphoblastic leukemia cells. Eicosapentaenoic Acid 17-38 caspase 3 Homo sapiens 106-115 28920465-7 2018 EPA induced 1.3-6 and 1.9-20-fold increases in caspase-3 activation and wt-p53 accumulation, respectively. Eicosapentaenoic Acid 0-3 caspase 3 Homo sapiens 47-56 26942868-4 2016 TOV-21G cells pretreated with peroxisome proliferator receptor activator gamma (PPARgamma) antagonist, GW9662, markedly suppressed EPA/DHA-induced apoptosis as determined by TUNEL assay, Annexin V-FITC/PI staining, and caspase-3 activity. Eicosapentaenoic Acid 131-134 caspase 3 Homo sapiens 219-228 34444777-8 2021 For example, the combination EPA/DHA + UDCA 50 microM caused comparable down-regulation of the CYP7A1 gene expression and of the BA-induced caspase 3 activity as observed with UDCA 500 microM. Eicosapentaenoic Acid 29-32 caspase 3 Homo sapiens 140-149 31614198-8 2020 Furthermore, we found that DHA and EPA treatment can either prevent caspase-3 activation on 17-kDa form cleavage or Bid cleaved (15-kDa form) for activation by caspase-8, apparently. Eicosapentaenoic Acid 35-38 caspase 3 Homo sapiens 68-77 27176035-7 2016 Simultaneously, EPA downregulated the phosphorylation status of mTOR, which may act as an upstream regulator of EPA-blocked nuclear factor kappaB (NF-kappaB) p65 translocation from the cytoplasm into the nucleus; the apoptotic mechanism of SKOV-3 cells induced by EPA was associated with the release of cytochrome c, Bax-to-Bcl-2 expression ratio, and activation of caspase-3 and caspase-9. Eicosapentaenoic Acid 16-19 caspase 3 Homo sapiens 366-375 27176035-7 2016 Simultaneously, EPA downregulated the phosphorylation status of mTOR, which may act as an upstream regulator of EPA-blocked nuclear factor kappaB (NF-kappaB) p65 translocation from the cytoplasm into the nucleus; the apoptotic mechanism of SKOV-3 cells induced by EPA was associated with the release of cytochrome c, Bax-to-Bcl-2 expression ratio, and activation of caspase-3 and caspase-9. Eicosapentaenoic Acid 112-115 caspase 3 Homo sapiens 366-375 26671842-8 2016 We also found that treatment for 48 h with 100 muM DHA and EPA, or their combination (50/50 muM), resulted in 2.9-, 3- and 2.6-fold increases in caspase-3 activation, as well as 54, 62.4 and 100% decreases in survivin mRNA expression levels, respectively, compared to untreated cells. Eicosapentaenoic Acid 59-62 caspase 3 Homo sapiens 145-154 26381084-6 2015 The inhibition of the autophagic process enhanced the cell viability, suppressed cell death, and decreased activation of caspase-3/7 indicating that EPA and DHA-induced autophagy amplified A549 apoptotic cell death. Eicosapentaenoic Acid 149-152 caspase 3 Homo sapiens 121-130 24896321-3 2014 In this study, we examined the influence of two Omega-3 PUFAs (DHA and EPA) on the proliferation and apoptosis of gastric cancer (GC) cells, and found that DHA and EPA reduced the viability of GC cells and induced apoptosis by activating caspase-3. Eicosapentaenoic Acid 164-167 caspase 3 Homo sapiens 238-247 25469820-7 2015 EPA inhibited SNP-induced chondrocyte apoptosis, caspase 3 and poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 MAPK and p53, and expression of MMP3 and MMP13. Eicosapentaenoic Acid 0-3 caspase 3 Homo sapiens 49-58 25529445-9 2015 Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of caspase-9 and caspase-3. Eicosapentaenoic Acid 41-44 caspase 3 Homo sapiens 164-173 25277647-7 2014 EPA and DHA inhibited NFkappaB activity and induced apoptosis through mitochondrial perturbation and caspase-3 activation. Eicosapentaenoic Acid 0-3 caspase 3 Homo sapiens 101-110 25745780-10 2014 Both, EPA and DHA, but not AA, significantly increased the amount of autophagic vacuoles and induced caspase-3/7 activity. Eicosapentaenoic Acid 6-9 caspase 3 Homo sapiens 101-110 24918290-4 2014 The results revealed that EPA attenuated PA-induced cell death and activation of apoptosis-related proteins, such as caspase-3, p53 and Bax. Eicosapentaenoic Acid 26-29 caspase 3 Homo sapiens 117-126 19887546-4 2009 DHA and EPA treatment resulted in a dose-dependent reduction of cell viability with cleavage of poly ADP ribose polymerase, caspase-3, and caspase-9 in three human HCC cell lines (Hep3B, Huh-7, HepG2). Eicosapentaenoic Acid 8-11 caspase 3 Homo sapiens 124-133 21325776-5 2011 Then, we showed that both EPA and ARA exerted a pro-apoptotic effect through the intrinsic mitochondrial apoptotic pathway including the dissipation of mitochondrial membrane potential followed by cardiolipin depletion, the downstream activation of caspase-3 and the increase in DNA fragmentation. Eicosapentaenoic Acid 26-29 caspase 3 Homo sapiens 249-258 22038211-6 2012 RESULTS: Treatment with EPA alone and DHA alone resulted in 22% and 9% attenuation of caspase-3/7 activity, respectively. Eicosapentaenoic Acid 24-27 caspase 3 Homo sapiens 86-95 22038211-7 2012 Caspase-3/7 activity was attenuated by 52% when cells were treated with a combination of EPA and DHA (P = .0034). Eicosapentaenoic Acid 89-92 caspase 3 Homo sapiens 0-9 22038211-9 2012 CONCLUSIONS: The combination of EPA and DHA resulted in a synergistic attenuation of bile acid-induced hepatocellular apoptosis, as assessed by caspase-3/7 activity, compared to EPA and DHA separately. Eicosapentaenoic Acid 32-35 caspase 3 Homo sapiens 144-153 19237174-8 2009 Subsequently caspase-3 activation and apoptosis were detected in eicosapentaenoic acid exposed cells, leading to decreased cell numbers. Eicosapentaenoic Acid 65-86 caspase 3 Homo sapiens 13-22 12371751-0 2002 Eicosapentaenoic acid promotes apoptosis in Ramos cells via activation of caspase-3 and -9. Eicosapentaenoic Acid 0-21 caspase 3 Homo sapiens 74-90 16157238-8 2005 Simultaneously, EPA treatment induced apoptosis and this was associated with caspase-3 activation. Eicosapentaenoic Acid 16-19 caspase 3 Homo sapiens 77-86 19116882-7 2009 DHA or EPA in combination with NaBt significantly increased caspase-3 activity compared to control. Eicosapentaenoic Acid 7-10 caspase 3 Homo sapiens 60-69 12371751-9 2002 Whereas inhibitors of caspase-3 and -9 reduced EPA-induced apoptosis, inhibition of caspase-8 did not. Eicosapentaenoic Acid 47-50 caspase 3 Homo sapiens 22-38 11413117-6 2001 RESULTS: Treatment of HT29 cells with EPA reduced viable cell number and activated caspase 3, prior to cell detachment. Eicosapentaenoic Acid 38-41 caspase 3 Homo sapiens 83-92