PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32397146-5 2020 Among them, eicosapentaenoic acid (EPA) esterified 12-hydroxy stearic acid (12-HSA) and 12-hydroxy oleic acid (12-HOA) FAHFAs showed less cytotoxicity compared to their free fatty acids and potent activators of Nrf2. Eicosapentaenoic Acid 12-33 NFE2 like bZIP transcription factor 2 Homo sapiens 211-215 32636362-7 2020 Using transcriptomic analyses, we showed that both EPA and DHA regulated pathways involved in oxidative stress and immune response [e.g., nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Signal transducer and activator of transcription 3 (STAT3), Interferon (IFN) and Interleukin (IL)-1 signaling], whereas DHA also regulated pathways involved in cell development and neuronal formation [e.g., cAMP-response element binding protein (CREB) signaling]. Eicosapentaenoic Acid 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 138-181 32636362-7 2020 Using transcriptomic analyses, we showed that both EPA and DHA regulated pathways involved in oxidative stress and immune response [e.g., nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Signal transducer and activator of transcription 3 (STAT3), Interferon (IFN) and Interleukin (IL)-1 signaling], whereas DHA also regulated pathways involved in cell development and neuronal formation [e.g., cAMP-response element binding protein (CREB) signaling]. Eicosapentaenoic Acid 51-54 NFE2 like bZIP transcription factor 2 Homo sapiens 183-187 32397146-5 2020 Among them, eicosapentaenoic acid (EPA) esterified 12-hydroxy stearic acid (12-HSA) and 12-hydroxy oleic acid (12-HOA) FAHFAs showed less cytotoxicity compared to their free fatty acids and potent activators of Nrf2. Eicosapentaenoic Acid 35-38 NFE2 like bZIP transcription factor 2 Homo sapiens 211-215 32397146-9 2020 These results suggest that EPA-derived FAHFAs as a new class of lipids with less cytotoxicity, and strong Nrf2 activators with plausible antioxidant effects via the induction of cytoprotective proteins against oxidative stress, induced cellular damage. Eicosapentaenoic Acid 27-30 NFE2 like bZIP transcription factor 2 Homo sapiens 106-110 25815672-0 2015 Effects of Eicosapentaenoic Acid on the Cytoprotection Through Nrf2-Mediated Heme Oxygenase-1 in Human Endothelial Cells. Eicosapentaenoic Acid 11-32 NFE2 like bZIP transcription factor 2 Homo sapiens 63-67 26177858-7 2015 KEY RESULTS: EPA offered significant cytoprotection by increasing EPA/AA ratios in cell membranes, inhibiting ROS generation, enhancing antioxidant status and modulating nuclear translocation of redox-sensitive transcription factors (NF-kappaB p65 and Nrf-2) and expression of NF-kappaB p65, COX-2 and Nrf-2. Eicosapentaenoic Acid 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 252-257 26177858-7 2015 KEY RESULTS: EPA offered significant cytoprotection by increasing EPA/AA ratios in cell membranes, inhibiting ROS generation, enhancing antioxidant status and modulating nuclear translocation of redox-sensitive transcription factors (NF-kappaB p65 and Nrf-2) and expression of NF-kappaB p65, COX-2 and Nrf-2. Eicosapentaenoic Acid 13-16 NFE2 like bZIP transcription factor 2 Homo sapiens 302-307 25815672-3 2015 In this study, we investigated the effect of EPA on the induction of HO-1 by NF-E2-related factor 2 (Nrf2) in human umbilical vein endothelial cells. Eicosapentaenoic Acid 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 77-99 25815672-3 2015 In this study, we investigated the effect of EPA on the induction of HO-1 by NF-E2-related factor 2 (Nrf2) in human umbilical vein endothelial cells. Eicosapentaenoic Acid 45-48 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 25815672-5 2015 Additionally, EPA treatment increased Nrf2 nuclear translocation and antioxidant response element activity, leading to the upregulation of HO-1 expression. Eicosapentaenoic Acid 14-17 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 25815672-8 2015 These data suggest that EPA protects against H(2)O(2)-induced oxidative stress in endothelial cells by activating Nrf2 and inducting HO-1 expression. Eicosapentaenoic Acid 24-27 NFE2 like bZIP transcription factor 2 Homo sapiens 114-118 34571936-7 2021 Pathways of necroptosis, ferroptosis, p53, NRF2, ATF4, WNT, MAPK, NF-kappaB, EGFR, and ERK may be connected to the tumor suppressive effect caused by pretreatment of DHA/EPA prior to bortezomib. Eicosapentaenoic Acid 170-173 NFE2 like bZIP transcription factor 2 Homo sapiens 43-47 23131562-6 2013 Knockdown of nuclear factor erythroid 2-related factor 2 (Nrf-2) significantly reduced EPA, DHA or 4-HHE-induced HO-1 mRNA and protein expression. Eicosapentaenoic Acid 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 13-56 23131562-6 2013 Knockdown of nuclear factor erythroid 2-related factor 2 (Nrf-2) significantly reduced EPA, DHA or 4-HHE-induced HO-1 mRNA and protein expression. Eicosapentaenoic Acid 87-90 NFE2 like bZIP transcription factor 2 Homo sapiens 58-63 23131562-8 2013 In conclusion, treatment with EPA and DHA induced HO-1 through the activation of Nrf-2 and prevented oxidative stress in 3T3-L1 adipocytes. Eicosapentaenoic Acid 30-33 NFE2 like bZIP transcription factor 2 Homo sapiens 81-86 17127771-5 2007 Liquid chromatography-tandem mass spectrometry analyses of oxidized EPA demonstrated the presence of novel cyclopentenone-containing molecules termed J3-isoprostanes in vitro and in vivo and were shown to induce Nrf2-directed gene expression. Eicosapentaenoic Acid 68-71 NFE2 like bZIP transcription factor 2 Homo sapiens 212-216 17127771-6 2007 These experiments provide a biochemical basis for the hypothesis that formation of J-ring compounds generated from oxidation of EPA and DHA in vivo can reach concentrations high enough to induce Nrf2-based cellular defense systems. Eicosapentaenoic Acid 128-131 NFE2 like bZIP transcription factor 2 Homo sapiens 195-199 33321955-5 2020 In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Eicosapentaenoic Acid 85-106 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 33321955-5 2020 In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Eicosapentaenoic Acid 108-111 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 33321955-5 2020 In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Eicosapentaenoic Acid 226-229 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54