PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32606775-0 2020 Eicosapentaenoic acid"s metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer. Eicosapentaenoic Acid 0-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 96-100 35067692-4 2022 It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE). Eicosapentaenoic Acid 55-76 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150 35067692-4 2022 It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE). Eicosapentaenoic Acid 78-81 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150 35067692-4 2022 It has been shown that the biosynthesis of SPMs called eicosapentaenoic acid (EPA)-derived E-series resolvins is initiated by aspirin-acetylated COX-2 from EPA, leading to 18-hydroperoxy-eicosapentaenoic acid (18-HpEPE). Eicosapentaenoic Acid 156-159 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150 35067692-6 2022 Our MD simulations, combined with QM/MM calculations, show that the potential energy barriers for the H16-abstraction from EPA, required for forming 18-HpEPE, are higher than for the H13-abstraction, thus explaining why 18-HpEPE is a marginal product of COX-2 catalysis. Eicosapentaenoic Acid 123-126 mitochondrially encoded cytochrome c oxidase II Homo sapiens 254-259 35067692-7 2022 By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system. Eicosapentaenoic Acid 45-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44 35067692-7 2022 By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system. Eicosapentaenoic Acid 45-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 215-220 35067692-7 2022 By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system. Eicosapentaenoic Acid 221-224 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-44 35067692-7 2022 By contrast, in the aspirin-acetylated COX-2/EPA complex, the H16proS-abstraction energy barriers are somewhat lower than the H13proS energy barriers and much smaller than the H16-transfer barriers in the wild type COX-2/EPA system. Eicosapentaenoic Acid 221-224 mitochondrially encoded cytochrome c oxidase II Homo sapiens 215-220 33040178-8 2021 The non-selective COX inhibitor aspirin and the selective COX-2 inhibitor celecoxib increased sensitivity of several human and mouse CRC cell lines to EPA in vitro. Eicosapentaenoic Acid 151-154 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-63 32606775-9 2020 Conclusion: Our data demonstrate that the EPA-15-LOX-1-miR-101-Cox2 signaling pathway owns a crucial position in the pathogenesis and development of diet-related CC. Eicosapentaenoic Acid 42-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-67 26922534-9 2016 The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA. Eicosapentaenoic Acid 208-211 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 32058033-12 2020 Both EPA and DHA (50 muM) significantly decreased cyclooxygenase (COX)-2 protein. Eicosapentaenoic Acid 5-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-72 28648567-8 2018 There was a tendency for both EPA and DHA groups to decrease COX-2 gene expressions. Eicosapentaenoic Acid 30-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 61-66 26177858-7 2015 KEY RESULTS: EPA offered significant cytoprotection by increasing EPA/AA ratios in cell membranes, inhibiting ROS generation, enhancing antioxidant status and modulating nuclear translocation of redox-sensitive transcription factors (NF-kappaB p65 and Nrf-2) and expression of NF-kappaB p65, COX-2 and Nrf-2. Eicosapentaenoic Acid 13-16 mitochondrially encoded cytochrome c oxidase II Homo sapiens 292-297 23658609-4 2013 We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells. Eicosapentaenoic Acid 114-135 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-76 24503478-6 2014 Nanodisc-reconstituted COX-2 exhibited similar kinetic profiles for the oxygenation of AA, eicosapentaenoic acid, and 1-arachidonoyl glycerol compared to those derived using detergent solubilized enzyme. Eicosapentaenoic Acid 91-112 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-28 23371504-2 2014 Here we investigated the effect of eicosapentaenoic acid (EPA) on the proliferation of human non-small cell lung cancer A549 (COX-2 over-expressing) and H1299 (COX-2 null) cells as well as their xenograft models. Eicosapentaenoic Acid 58-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 126-131 23371504-5 2014 Intriguingly, when COX-2 expression was reduced by siRNA or shRNA in A549 cells, the antiproliferative activity of EPA was reduced substantially compared to that of control siRNA or shRNA transfected A549 cells. Eicosapentaenoic Acid 115-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 19-24 23371504-10 2014 Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3. Eicosapentaenoic Acid 69-72 mitochondrially encoded cytochrome c oxidase II Homo sapiens 102-107 23371504-10 2014 Taken together, the results of our study suggest that the ability of EPA to generate PGE3 through the COX-2 enzyme might be critical for EPA-mediated tumor growth inhibition which is at least partly due to down-regulation of Akt phosphorylation by PGE3. Eicosapentaenoic Acid 137-140 mitochondrially encoded cytochrome c oxidase II Homo sapiens 102-107 23658609-4 2013 We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells. Eicosapentaenoic Acid 137-140 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-76 19885014-5 2009 Results showed that EPA, DHA, or troglitazone significantly reduced COX-2 expression, NF-kappaB luciferase activity, and PGE(2) and IL-6 production in a dose-dependent fashion. Eicosapentaenoic Acid 20-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 68-73 19885014-0 2009 DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells. Eicosapentaenoic Acid 8-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 20600307-8 2010 The protective effect of EPA on osteoblastogenesis could be mediated by the biphasic cross-talk between PGE(2) and NO production involving COX-2 and iNOS pathways. Eicosapentaenoic Acid 25-28 mitochondrially encoded cytochrome c oxidase II Homo sapiens 139-144 19601807-2 2009 Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production. Eicosapentaenoic Acid 48-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 141-146 19601807-2 2009 Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production. Eicosapentaenoic Acid 70-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 141-146 16523199-5 2006 This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398. Eicosapentaenoic Acid 148-169 mitochondrially encoded cytochrome c oxidase II Homo sapiens 245-250 17178390-5 2007 EPA also attenuated the production of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and proinflammatory cytokines at mRNA and/or protein levels. Eicosapentaenoic Acid 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 38-60 18437081-5 2008 The COX-2-dependent mechanism of eicosapentaenoic acid was mediated by binding of PGE3 to EP2 and EP4 receptors. Eicosapentaenoic Acid 33-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 16190133-6 2005 In contrast, increase in the concentrations of DGLA, AA, EPA, and DHA is much less with specific COX-2 inhibitors since they do not block the formation of eicosanoids through COX-1 pathway. Eicosapentaenoic Acid 57-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 97-102 26335632-12 2015 DHA and EPA supplementation affected HMGECs in vitro and supported anti-inflammatory effects by influencing cytokine levels, decreasing COX-2 expression and increasing the production of RvD1. Eicosapentaenoic Acid 8-11 mitochondrially encoded cytochrome c oxidase II Homo sapiens 136-141 16190133-4 2005 The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 152-173 mitochondrially encoded cytochrome c oxidase II Homo sapiens 46-51 16190133-4 2005 The inhibitory action of aspirin on COX-1 and COX-2 enzymes enhances the tissue concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Eicosapentaenoic Acid 175-178 mitochondrially encoded cytochrome c oxidase II Homo sapiens 46-51 15990700-2 2005 In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids. Eicosapentaenoic Acid 173-194 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 15990700-2 2005 In contrast, aspirin blocks both COX-1 and COX-2 enzymes that, in turn, increases intracellular concentrations of dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and reduced formation of eicosanoids. Eicosapentaenoic Acid 196-199 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 12663496-6 2003 However, stimulation of COX-2 activity by IL-1 beta resulted in a decrease in cell proliferation and an induction of cytotoxicity by AA as well as by EPA. Eicosapentaenoic Acid 150-153 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 10457118-9 1999 In contrast, in the cell-free homogenate of cultured human mast cells, EPA inhibited both COX-1 and COX-2 activities. Eicosapentaenoic Acid 71-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 10457118-10 1999 CONCLUSION: Pre-incubation with EPA primarily affects the COX-2 pathway in cultured human mast cells and reduces PGD2 generation in response to IgE-anti-IgE challenge incubation. Eicosapentaenoic Acid 32-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-63