PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3035097-9 1987 Competition curves for the binding of unlabeled DN-1417 to limbic forebrain and lumbosacral spinal cord ([3H]TRH as assay ligand) were monophasic (not biphasic like those of Funatsu et al.) dn 48-50 thyrotropin releasing hormone Rattus norvegicus 109-112 2989427-7 1985 Experiments using DN-1417 (gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate), a synthetic TRH analogue with a more potent central activity, indicated the presence of TRH receptors having a high affinity to DN-1417 at least in the limbic forebrain but not in the pituitary. dn 18-20 thyrotropin releasing hormone Rattus norvegicus 105-108 2989427-7 1985 Experiments using DN-1417 (gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate), a synthetic TRH analogue with a more potent central activity, indicated the presence of TRH receptors having a high affinity to DN-1417 at least in the limbic forebrain but not in the pituitary. dn 18-20 thyrotropin releasing hormone Rattus norvegicus 181-184 3081836-1 1986 The effects of a recently synthesized analogue, thyrotropin-releasing hormone (TRH) analogue, DN-1417, on evoked responses and long-term potentiation (LTP) of the perforant path input to the dentate gyrus were examined in normal rats and after hypophysectomy. dn 94-96 thyrotropin releasing hormone Rattus norvegicus 48-77 3081836-1 1986 The effects of a recently synthesized analogue, thyrotropin-releasing hormone (TRH) analogue, DN-1417, on evoked responses and long-term potentiation (LTP) of the perforant path input to the dentate gyrus were examined in normal rats and after hypophysectomy. dn 94-96 thyrotropin releasing hormone Rattus norvegicus 79-82 3928465-0 1985 [A TRH analog (DN-1417). dn 15-17 thyrotropin releasing hormone Rattus norvegicus 3-6 2869169-10 1985 (5) [3H]-TRH binding: The addition of 10(-6) to 10(-4) M of DN-1417 and TRH inhibited concentration-dependently [3H]-TRH binding in the nucleus accumbens and striatal slices. dn 60-62 thyrotropin releasing hormone Rattus norvegicus 9-12 6413736-0 1983 A TRH analog (DN-1417): effects on local cerebral glucose utilization in conscious and pentobarbitalized rats determined by the autoradiographic 2-deoxy-[14C]glucose method. dn 14-16 thyrotropin releasing hormone Rattus norvegicus 2-5 6428117-3 1984 The potency of DN-1417 related to TSH release was 0.14-0.26% that of TRH. dn 15-17 thyrotropin releasing hormone Rattus norvegicus 69-72 6139495-11 1983 alpha-Methyl-p-tyrosine (alpha-MT, 250 mg/kg i.p., 4 hr before), a tyrosine hydroxylase inhibitor, almost completely blocked DN-1417- and MAP-induced increases in cyclic nucleotides, slightly blocked TRH-effects, and had no effect on Apo-effects. dn 125-127 thyrotropin releasing hormone Rattus norvegicus 200-203 3928869-5 1985 Dose-proportional transfer of DN-1417 through the everted small intestine was also found within the concentration range from 120 ng/ml to 27 mg/ml, whereas the transfer ratio of TRH decreased with increase in the concentration of TRH. dn 30-32 thyrotropin releasing hormone Rattus norvegicus 178-181 3928869-5 1985 Dose-proportional transfer of DN-1417 through the everted small intestine was also found within the concentration range from 120 ng/ml to 27 mg/ml, whereas the transfer ratio of TRH decreased with increase in the concentration of TRH. dn 30-32 thyrotropin releasing hormone Rattus norvegicus 230-233 3924795-0 1985 [A TRH analog (DN-1417). dn 15-17 thyrotropin releasing hormone Rattus norvegicus 3-6 3924797-0 1985 [A TRH analog (DN-1417). dn 15-17 thyrotropin releasing hormone Rattus norvegicus 3-6 6410685-4 1983 DN 1417, a potent analogue of TRH with a very low TSH (thyroid stimulating hormone) releasing activity was more effective in stimulating respiratory frequency, while TRH-OH, regarded to have neither TSH releasing nor extra hypothalamic effects, at equimolar doses was unable to induce any changes in the respiratory pattern. dn 0-2 thyrotropin releasing hormone Rattus norvegicus 30-33