PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16459022-5 2006 Quantitative in situ hybridization histochemistry showed that SL327 abolished the high levels of preproenkephalin and preprodynorphin mRNA induced by amphetamine in the striatum with no alteration of their basal levels. Amphetamine 150-161 prodynorphin Rattus norvegicus 118-133 16459022-7 2006 U0126 also blocked the amphetamine-induced increases in phospho-extracellular-regulated kinase and preproenkephalin and preprodynorphin gene expression in the striatum. Amphetamine 23-34 prodynorphin Rattus norvegicus 120-135 9027410-0 1997 Amphetamine-induced preprodynorphin mRNA expression and kappa-opioid receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam. Amphetamine 0-11 prodynorphin Rattus norvegicus 20-35 14521997-6 2003 Quantitative in situ hybridization histochemistry revealed that CTAP blocked amphetamine-induced preprodynorphin and substance P mRNA. Amphetamine 77-88 prodynorphin Rattus norvegicus 97-112 12523490-0 2002 Effect of cocaine and amphetamine on biosynthesis of proenkephalin and prodynorphin in some regions of the rat limbic system. Amphetamine 22-33 prodynorphin Rattus norvegicus 71-83 12523490-3 2002 The goal of the present study was to investigate the influence of acutely and chronically administered drugs of abuse, cocaine and amphetamine on biosynthesis of prodynorphin and proenkephalin in the rat amygdala, the structure involved in the mechanism of drug addiction. Amphetamine 131-142 prodynorphin Rattus norvegicus 162-174 12523490-7 2002 Chronic amphetamine (2.5 mg/kg twice daily for 5 days) administration decreased proenkephalin and increased prodynorphin mRNA level in the central nucleus of the amygdala (at 24 and 48 h). Amphetamine 8-19 prodynorphin Rattus norvegicus 108-120 12523490-8 2002 Moreover, significant increase in prodynorphin mRNA level was observed in the hippocampal dentate gyrus after acute (cocaine) and chronic (cocaine, amphetamine) administration of the psychostimulants. Amphetamine 148-159 prodynorphin Rattus norvegicus 34-46 8923522-1 1996 This study investigated the effects of pharmacological blockade or stimulation of muscarinic receptors on constitutive and amphetamine-stimulated preprodynorphin, substance P and pre-proenkephalin gene expression in rat striatum. Amphetamine 123-134 prodynorphin Rattus norvegicus 146-161 8923522-4 1996 Pretreatment with scopolamine (2.5 mg/kg, s.c.) significantly augmented striatal induction of preprodynorphin and substance P messenger RNA induced by acute injection of amphetamine (1.25 and 2.5 mg/kg, i.p. Amphetamine 170-181 prodynorphin Rattus norvegicus 94-109 8947932-1 1996 One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens. Amphetamine 150-161 prodynorphin Rattus norvegicus 297-312 8938822-0 1996 Nitric oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat. Amphetamine 48-59 prodynorphin Rattus norvegicus 68-80 8938822-10 1996 had no effect on the level of prodynorphin mRNA, but prevented dose-dependently the amphetamine-induced increase in prodynorphin gene expression in both the nucleus accumbens and the striatum. Amphetamine 84-95 prodynorphin Rattus norvegicus 116-128 8787127-0 1996 D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine. Amphetamine 120-131 prodynorphin Rattus norvegicus 54-69 8787127-1 1996 Our previous work has demonstrated a dose-dependent induction of striatal preprodynorphin (PPD) in response to a single injection of the psychostimulants amphetamine (AMPH) or methamphetamine (METH). Amphetamine 154-165 prodynorphin Rattus norvegicus 74-89 8787127-1 1996 Our previous work has demonstrated a dose-dependent induction of striatal preprodynorphin (PPD) in response to a single injection of the psychostimulants amphetamine (AMPH) or methamphetamine (METH). Amphetamine 167-171 prodynorphin Rattus norvegicus 74-89 7752096-0 1995 Dose-dependent alteration in zif/268 and preprodynorphin mRNA expression induced by amphetamine or methamphetamine in rat forebrain. Amphetamine 84-95 prodynorphin Rattus norvegicus 41-56 7606440-0 1995 Alterations in striatal zif/268, preprodynorphin and preproenkephalin mRNA expression induced by repeated amphetamine administration in rats. Amphetamine 106-117 prodynorphin Rattus norvegicus 33-48 7886627-0 1994 NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. Amphetamine 23-34 prodynorphin Rattus norvegicus 71-86 7477938-0 1995 A single injection of amphetamine or methamphetamine induces dynamic alterations in c-fos, zif/268 and preprodynorphin messenger RNA expression in rat forebrain. Amphetamine 22-33 prodynorphin Rattus norvegicus 103-118 7477938-8 1995 This study, together with our recently published observation that preprodynorphin messenger RNA is induced in the caudate 3, 6 and 18 h after amphetamine or methamphetamine injection, provides a detailed dynamic description of the differential modulation of c-fos, zif/268 and preprodynorphin messenger RNA expression in the cerebral cortex and striatum by amphetamines over time. Amphetamine 142-153 prodynorphin Rattus norvegicus 66-81 7477938-9 1995 These data implicate immediate early gene and preprodynorphin gene expression in the differential response of medium spiny striatal neurons to methamphetamine and amphetamine. Amphetamine 147-158 prodynorphin Rattus norvegicus 46-61 7718243-0 1995 Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Amphetamine 23-34 prodynorphin Rattus norvegicus 73-85 7877442-0 1994 Role of kainate/AMPA receptors in induction of striatal zif/268 and preprodynorphin mRNA by a single injection of amphetamine. Amphetamine 114-125 prodynorphin Rattus norvegicus 68-83 7909579-4 1994 These data indicate that prolonged elevation of preprodynorphin expression may alter the responsiveness of striatonigral neurons to subsequent amphetamine exposure. Amphetamine 143-154 prodynorphin Rattus norvegicus 48-63