PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31622780-9 2020 STATEMENT OF SIGNIFICANCE: We developed an adaptive in vivo sensing device whereby a drug, aspirin, can be released upon the detection of a proinflammatory cytokine, interferon-gamma (IFN-gamma), in real time with a sensitivity of 10 pg mL-1. Aspirin 91-98 interferon gamma Homo sapiens 184-193 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Aspirin 26-33 interferon gamma Homo sapiens 126-135 31622780-4 2020 This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-gamma (IFN-gamma)) in real time. Aspirin 156-163 interferon gamma Homo sapiens 255-271 31622780-4 2020 This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-gamma (IFN-gamma)) in real time. Aspirin 156-163 interferon gamma Homo sapiens 273-282 27423494-13 2016 IFN-gamma-matured eosinophil progenitors showed enhanced hPGDS expression and increased levels of PGD2 release at baseline and after aspirin stimulation. Aspirin 133-140 interferon gamma Homo sapiens 0-9 31622780-9 2020 STATEMENT OF SIGNIFICANCE: We developed an adaptive in vivo sensing device whereby a drug, aspirin, can be released upon the detection of a proinflammatory cytokine, interferon-gamma (IFN-gamma), in real time with a sensitivity of 10 pg mL-1. Aspirin 91-98 interferon gamma Homo sapiens 166-182 30276549-11 2018 ELISA analysis showed that aspirin significantly decreased the production of inflammatory cytokines IFN-gamma (p value < 0.05) and IL-8 (p value < 0.001) in PE-DMSCs. Aspirin 27-34 interferon gamma Homo sapiens 100-109 25169677-10 2015 Pretreatment of LPS/IFNgamma-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant GSH, the H2S donor NaSH, and the anti-inflammatory cytokine IL-10, resulted in a CM with diminished ability to stimulate tau expression. Aspirin 122-129 interferon gamma Homo sapiens 20-28 23912646-4 2013 In this study, the release of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-gamma) by CD4+ T lymphocytes prior to aspirin desensitization were also measured at intracellular levels, and expression of these cytokines after 1 month aspirin desensitization was evaluated. Aspirin 138-145 interferon gamma Homo sapiens 96-105 24717792-14 2014 The study confirms aspirin desensitization is effective clinically in AERD patients and suggests that IFN gamma and IL-10 expression in CD4(+) T lymphocytes may be related to the mechanism of action. Aspirin 19-26 interferon gamma Homo sapiens 102-111 23912646-4 2013 In this study, the release of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-gamma) by CD4+ T lymphocytes prior to aspirin desensitization were also measured at intracellular levels, and expression of these cytokines after 1 month aspirin desensitization was evaluated. Aspirin 254-261 interferon gamma Homo sapiens 96-105 23969075-10 2014 Patients with aspirin intolerance had higher levels of IFN-gamma (4.7+-1.4 vs. 4.1+-0.6, respectively, p=0.022). Aspirin 14-21 interferon gamma Homo sapiens 55-64 23969075-12 2014 IFN-gamma seems to be down-regulated in the patients with CRSwNP, but could be over-expressed in the presence of aspirin intolerance. Aspirin 113-120 interferon gamma Homo sapiens 0-9 23806637-0 2013 Prominent role of IFN-gamma in patients with aspirin-exacerbated respiratory disease. Aspirin 45-52 interferon gamma Homo sapiens 18-27 23806637-5 2013 RESULTS: Gene expression analysis revealed that tissue from both aspirin-tolerant subjects and patients with AERD display a TH2 cytokine signature; however, AERD was distinguished from chronic hyperplastic eosinophilic sinusitis by the prominent expression of IFN-gamma. Aspirin 65-72 interferon gamma Homo sapiens 260-269 23806637-10 2013 CONCLUSIONS: High IFN-gamma levels distinguish AERD from aspirin-tolerant asthma and underlie the robust constitutive and aspirin-induced secretion of CysLTs that characterize this disorder. Aspirin 57-64 interferon gamma Homo sapiens 18-27 23806637-10 2013 CONCLUSIONS: High IFN-gamma levels distinguish AERD from aspirin-tolerant asthma and underlie the robust constitutive and aspirin-induced secretion of CysLTs that characterize this disorder. Aspirin 122-129 interferon gamma Homo sapiens 18-27 17869645-6 2007 Both BAY- and ASA-allogeneic DC and autologous alloantigen pulsed DC were weaker stimulators of T cells (by MLR) compared with controls, and there was reduced IL-2 and IFN-gamma production by T cells stimulated with BAY-DC or ASA-DC (by ELISPOT) (more marked results were always observed with ASA-treated DC). Aspirin 14-17 interferon gamma Homo sapiens 168-177 18201436-8 2007 Aspirin desensitization differentially affects interferon (IFN) gamma expression. Aspirin 0-7 interferon gamma Homo sapiens 47-69 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 0-7 interferon gamma Homo sapiens 95-104 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 0-7 interferon gamma Homo sapiens 156-165 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 30-37 interferon gamma Homo sapiens 95-104 18201436-10 2007 Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation. Aspirin 30-37 interferon gamma Homo sapiens 156-165 23057161-9 2012 Aspirin-, dexamethasone- VD3- and butyric acid-modified DCs suppressed interferon-gamma production, proliferation and cytotoxicity in co-culture with allogeneic mononuclear cells, but inconsistent results were obtained with different allogeneic combinations. Aspirin 0-7 interferon gamma Homo sapiens 71-87 20349206-4 2011 With RKO cells, aspirin reduced IL-6, IL-1ra, and IL-10 synthesis and enhanced IFNgamma secretion, while IL-1beta remained unchanged. Aspirin 16-23 interferon gamma Homo sapiens 79-87 15762873-12 2005 The influence of aspirin on biochemical pathways induced by IFN-gamma may represent an important part of its broad pharmacological effect. Aspirin 17-24 interferon gamma Homo sapiens 60-69 12112002-6 2002 And, NSAIDs aspirin and diclofenase dose dependently inhibited LPS/IFN-gamma-induced HO-1 protein accompanied by suppression of PGE(2) (not NO) production. Aspirin 12-19 interferon gamma Homo sapiens 67-76 11840449-7 2002 The ability of dexamethasone and ASA to suppress IFNgamma and interleukin-1beta (IL-1beta) messenger RNA and protein production was also tested in vitro using T cell clones and monocytes derived from patients with GCA. Aspirin 33-36 interferon gamma Homo sapiens 49-57 7560666-16 1995 Aspirin sensitivity is strongly correlated with nonallergic CHS/NP and production of the nonallergic CHS/NP profile of cytokines, including IFN-gamma. Aspirin 0-7 interferon gamma Homo sapiens 140-149 10860828-4 2000 The present study was designed to elucidate sequentially the action mechanisms of acetaminophen and salicylates (aspirin and sodium salicylate) on lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma)-induced iNOS expression in RAW 264.7 macrophages. Aspirin 113-120 interferon gamma Homo sapiens 177-204 10433370-5 1999 We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Aspirin 29-36 interferon gamma Homo sapiens 72-81 11022121-0 2000 A short course of oral aspirin increases IL-18-induced interferon-gamma production in whole blood cultures. Aspirin 23-30 interferon gamma Homo sapiens 55-71 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interferon gamma Homo sapiens 100-116 11022121-2 2000 Four days after cessation of a 3-day regimen of 650 mg of oral aspirin, there was a 70% increase in interferon-gamma (IFN-gamma) production, stimulated by a combination of interleukin-18 (IL-18) plus lipopolysaccharide (p < 0.05). Aspirin 63-70 interferon gamma Homo sapiens 118-127 11022121-4 2000 TNF-alpha and IFN-gamma production returned to pre-aspirin levels one month after the discontinuation of aspirin. Aspirin 51-58 interferon gamma Homo sapiens 14-23 7560666-11 1995 A clinical history of aspirin sensitivity was strongly correlated with nonallergic CHS/NP, as well as the nonallergic CHS/NP profile of cytokines, including IFN-gamma. Aspirin 22-29 interferon gamma Homo sapiens 157-166 2504679-5 1989 Peak IFN-gamma production by PHA-stimulated PBLs was observed after 24 h of incubation with TF5 and after 72 h with aspirin. Aspirin 116-123 interferon gamma Homo sapiens 5-14 2169174-4 1990 The results of these experiments showed that aspirin and indomethacin cause a marked increase of IFN-gamma production by GO- and SEB-activated PBMC. Aspirin 45-52 interferon gamma Homo sapiens 97-106 2504679-0 1989 Aspirin and thymosin increase interleukin-2 and interferon-gamma production by human peripheral blood lymphocytes. Aspirin 0-7 interferon gamma Homo sapiens 48-64 2504679-8 1989 Oral administration of aspirin in normal volunteers significantly enhanced production of both IFN-gamma and IL-2. Aspirin 23-30 interferon gamma Homo sapiens 94-103