PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16460959-15 2006 It could be stressed that aspirin, unlike other non-selective and selective COX-2 inhibitors increases the risk of the abdominal wall defects, which are observed more often in growth-retarded fetuses. Aspirin 26-33 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 76-81 15326064-5 2004 When ATL synthesis was inhibited by pretreatment with a selective cyclooxygenase-2 inhibitor (celecoxib) or a 5-lipoxygenase inhibitor (zileuton), the aspirin-induced increase in BP was significantly augmented. Aspirin 151-158 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-82 15851630-6 2005 Moreover, angiotensin II selectively increased cardiac cyclooxygenase-2 but not cyclooxygenase-1 expression, which was totally prevented by acetylsalicylic acid treatment. Aspirin 140-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 55-71 15755648-8 2005 A molecular modeling (docking) study indicated that the SO(2)NHCOCH(3) substituent present in N-acetyl-2-carboxy-4-(2,4-fluorophenyl)benzenesulfonamide, like the acetoxy substituent in aspirin, is suitably positioned to acetylate the Ser(530) hydroxyl group in the COX-2 primary binding site. Aspirin 185-192 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 265-270 12807437-7 2003 Ascorbic acid alone or in combination with acetylsalicylic acid did not inhibit cyclooxygenase-2 (COX-2) protein synthesis but inhibited COX-2 enzyme activity. Aspirin 43-63 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 137-142 12404234-0 2002 Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. Aspirin 68-75 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-16 12404234-3 2002 We determined whether aspirin-triggered lipoxin (LX) production via COX-2 diminishes aspirin-induced damage in the rat stomach. Aspirin 22-29 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-73 12404234-3 2002 We determined whether aspirin-triggered lipoxin (LX) production via COX-2 diminishes aspirin-induced damage in the rat stomach. Aspirin 85-92 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-73 12404234-9 2002 Aspirin rapidly up-regulated COX-2 expression in the stomach and caused a significant increase in gastric 15(R)-epi-LXA4 production, which was abolished by celecoxib. Aspirin 0-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 29-34 12404234-11 2002 CONCLUSIONS: Aspirin administration results in elevated production of 15(R)-epi-LXA4 via COX-2. Aspirin 13-20 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 89-94 12404234-13 2002 Co-administration of aspirin and a selective COX-2 inhibitor results in substantially more severe gastric injury than is produced with either agent alone. Aspirin 21-28 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 45-50 12404234-2 2002 Acetylation of COX-2 by aspirin can result in production of an antiinflammatory substance, 15(R)-epi-LXA4. Aspirin 24-31 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 15-20 9760036-5 1998 In contrast, at 3 h after carrageenin injection, cyclooxygenase 2 inhibitors significantly inhibited all inflammatory parameters however suppression with piroxicam and aspirin was greater, and more pronounced than at 6 h. NS-398 and nimesulide dosing did not reduce thromboxane B2 production from platelets isolated from rats with carrageenin-induced pleurisy, demonstrating that at the doses used, cyclooxygenase 2 inhibitors did not inhibit cyclooxygenase 1, as platelets contain only this isoform. Aspirin 168-175 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 49-65 9760036-5 1998 In contrast, at 3 h after carrageenin injection, cyclooxygenase 2 inhibitors significantly inhibited all inflammatory parameters however suppression with piroxicam and aspirin was greater, and more pronounced than at 6 h. NS-398 and nimesulide dosing did not reduce thromboxane B2 production from platelets isolated from rats with carrageenin-induced pleurisy, demonstrating that at the doses used, cyclooxygenase 2 inhibitors did not inhibit cyclooxygenase 1, as platelets contain only this isoform. Aspirin 168-175 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 399-415 31852420-7 2020 These effects were related to the ability of aspirin to prevent the adhesion of leukocytes to endothelial cells via inhibition of the platelet cyclooxygenase 1 but not the cyclooxygenase 2 pathway. Aspirin 45-52 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 172-188 9663836-0 1997 Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats. Aspirin 0-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 38-55 9596581-0 1998 Aspirin-like molecules that covalently inactivate cyclooxygenase-2. Aspirin 0-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 50-66 9596581-1 1998 Many of aspirin"s therapeutic effects arise from its acetylation of cyclooxygenase-2 (COX-2), whereas its antithrombotic and ulcerogenic effects result from its acetylation of COX-1. Aspirin 8-15 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 68-84 9596581-1 1998 Many of aspirin"s therapeutic effects arise from its acetylation of cyclooxygenase-2 (COX-2), whereas its antithrombotic and ulcerogenic effects result from its acetylation of COX-1. Aspirin 8-15 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 86-91 9596581-2 1998 Here, aspirin-like molecules were designed that preferentially acetylate and irreversibly inactivate COX-2. Aspirin 6-13 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 101-106 30604228-13 2019 CONCLUSION: Aspirin attenuates podocyte injury in DN, which may be through COX-2-mediated dysregulation of LDLr pathway. Aspirin 12-19 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 75-80 31781346-11 2019 Histological analysis showed that aspirin treatment prevented the loss of COL2 and decreased MMP-3 and MMP-13, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), IL-1beta, and TNF-alpha expression in the IVD tissues. Aspirin 34-41 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-157 31781346-11 2019 Histological analysis showed that aspirin treatment prevented the loss of COL2 and decreased MMP-3 and MMP-13, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), IL-1beta, and TNF-alpha expression in the IVD tissues. Aspirin 34-41 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 159-164 30604228-0 2019 Aspirin attenuates podocyte injury in diabetic rats through overriding cyclooxygenase-2-mediated dysregulation of LDL receptor pathway. Aspirin 0-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 71-87 30604228-12 2019 However, when COX-2 expression was inhibited by aspirin, these changes in the DM rats were significantly attenuated. Aspirin 48-55 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 14-19 25342594-7 2015 Either Aspirin or LUT gavages alone or combined produce a significant decrease in colon polyp number and size, significantly decreasing CEA, COX-2, and oxidative stress and increasing antioxidant markers. Aspirin 7-14 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 141-146 20640495-3 2010 Dipyridamole (DIP) augments the IS-limiting effects of statins by blocking the cellular reuptake of adenosine; whereas aspirin (ASA) attenuates the effect by inhibiting COX2. Aspirin 119-126 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 169-173 20640495-3 2010 Dipyridamole (DIP) augments the IS-limiting effects of statins by blocking the cellular reuptake of adenosine; whereas aspirin (ASA) attenuates the effect by inhibiting COX2. Aspirin 128-131 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 169-173 26426591-8 2015 While cyclooxygenase-1 protein decreased with the three drugs tested but not with L-NAME (p < 0.05), the cyclooxygenase-2 protein decreased only with aspirin and parecoxib (p < 0.05). Aspirin 153-160 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 108-124 22932114-20 2012 Aspirin could prevent bone loss by decreasing COX-2 expression in OVX rats. Aspirin 0-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 46-51 22045867-4 2012 We hypothesised that inhibition of MMP-2 and MMP-9 by minocycline can be potentiated by aspirin through inhibition of cyclooxygenase-2 and tissue plasminogen activator, resulting in amelioration of clinical cerebral ischaemia in diabetes. Aspirin 88-95 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 118-134 21640159-8 2011 However, in these rats adjunctive aspirin treatment significantly improved the depressive behaviors and downregulated the COX-2 level and PGE(2) concentration in the hippocampus. Aspirin 34-41 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 122-127 21640159-9 2011 Thus, our results suggest that aspirin can be served as an effective adjunctive agent in the treatment resistant depression mediated by inhibition of the COX-2 level and PGE(2) concentration. Aspirin 31-38 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 154-159 17526656-9 2007 In addition, NO-aspirin downregulated inducible NO synthase (iNOS; 0.37-fold, P < 0.01) and cyclooxygenase-2 (COX-2; 0.61-fold, P < 0.05) gene expression compared with the vehicle group after 48 h of reperfusion. Aspirin 16-23 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 95-111 17526656-9 2007 In addition, NO-aspirin downregulated inducible NO synthase (iNOS; 0.37-fold, P < 0.01) and cyclooxygenase-2 (COX-2; 0.61-fold, P < 0.05) gene expression compared with the vehicle group after 48 h of reperfusion. Aspirin 16-23 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 113-118 18332613-0 2007 Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition? Aspirin 18-25 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 97-113