PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21617849-3 2011 In the present study, we observed that aspirin caused G0/G1 phase cell cycle arrest and reduced etoposide induced caspase-3 activation in hepatocellular carcinoma G2 (HepG2) cells. Aspirin 39-46 caspase 3 Homo sapiens 114-123 21617849-9 2011 Moreover, reduction of caspase-3 activity induced by aspirin was attenuated by silencing p21(cip) expression. Aspirin 53-60 caspase 3 Homo sapiens 23-32 21617849-10 2011 These results indicated that the anti-apoptotic effect of aspirin was dependent on activation of Akt which inhibited cell apoptosis by up-regulating p21(cip) and blocking caspase-3 activation. Aspirin 58-65 caspase 3 Homo sapiens 171-180 19922491-8 2010 Both 2HBZ and ASA induced caspase-3 activation in the cells, which confirmed that their cytotoxic effects were the result of apoptotic cell death. Aspirin 14-17 caspase 3 Homo sapiens 26-35 20674154-6 2010 NO-Aspirin and NO-naproxen reduced NF-kappaB protein levels, and activated caspase-3 enzyme in a dose- and time-dependent manner. Aspirin 3-10 caspase 3 Homo sapiens 75-84 19706045-8 2009 Stimulating the Wnt/beta-catenin pathway by both Wnt 3a and GSK-3beta inhibitors (LiCl and SB 216763), blocked aspirin-induced apoptosis and protected mitochondrial function, as demonstrated by decreased cytochrome c release and caspase-3 activity. Aspirin 111-118 caspase 3 Homo sapiens 229-238 19706045-12 2009 CONCLUSION: These results demonstrate that the Wnt/beta-catenin pathway is a key modulator of aspirin-induced apoptosis in MSCs by regulation of mitochrondrial/caspase-3 function. Aspirin 94-101 caspase 3 Homo sapiens 160-169 15567157-4 2005 The para isomer of NO-ASA degraded beta-catenin in a dose- and time-dependent manner coinciding with increasing expression of activated caspase-3. Aspirin 22-25 caspase 3 Homo sapiens 136-145 19266085-10 2008 Therefore, we conclude that aspirin-induced calpain mediates an antitumor effect via caspase-3 in cervical cancer cells. Aspirin 28-35 caspase 3 Homo sapiens 85-94 19706045-7 2009 RESULTS: In these MSCs, aspirin induced morphological changes characteristic of apoptosis, cytochrome c release from mitochondria, and caspase-3 activation. Aspirin 24-31 caspase 3 Homo sapiens 135-144 14753751-6 2003 Additionally, aspirin effectively prevents caspase-3 and caspase-9 (cysteinyl aspartate-specific proteases) activation by H2O2. Aspirin 14-21 caspase 3 Homo sapiens 43-52 32545774-3 2020 We found that the human H4 glioma cell-killing effects of aspirin involved mitochondria-mediated apoptosis accompanied by endoplasmic reticulum (ER) stress, Noxa upregulation, Mcl-1 downregulation, Bax mitochondrial distribution and oligomerization, and caspase 3/caspase 8/caspase 9 activation. Aspirin 58-65 caspase 3 Homo sapiens 254-263 11532860-11 2001 Inhibition of caspase-3 rescued aspirin-induced apoptosis. Aspirin 32-39 caspase 3 Homo sapiens 14-23 11532860-12 2001 Our results suggest that one of the major pathways which mediates the anti-tumour response of aspirin and indomethacin in gastric cancer cells is through up-regulation of bax and bak and activation of caspase-3. Aspirin 94-101 caspase 3 Homo sapiens 201-210 12490308-0 2003 The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cell. Aspirin 26-33 caspase 3 Homo sapiens 97-106 12490308-11 2003 We have demonstrated that combined treatment of aspirin and radiation induces the antitumor effect mediated by bcl-2 and caspase-3 pathway in cervical cancer cells. Aspirin 48-55 caspase 3 Homo sapiens 121-130 34319045-16 2021 Dox-loaded ASA inhibited the proliferation of SW480 cells, because the aptamer facilitated the Dox uptake into these cells which caused the cell apoptosis, indicated by the significant decrease in procaspase-3, apoptosis marker protein. Aspirin 11-14 caspase 3 Homo sapiens 197-209 33111589-7 2021 However, only after calcium ionophore A23187 stimulation, caspase-3 activity, the cytosolic cytochrome C content, and reduction of mitochondrial membrane potential were higher in PLPs from ASA-incubated megakaryocytes than in those from Meg-01 without ASA. Aspirin 189-192 caspase 3 Homo sapiens 58-67 33111589-9 2021 The L-arginine antagonist, NG-Nitro-L-arginine Methyl Ester, reduced caspase-3 activity in A23187-stimulated PLPs generated from ASA-incubated Meg-01 cells. Aspirin 129-132 caspase 3 Homo sapiens 69-78 33116404-16 2020 Aspirin dose- and time-dependently induced CellEvent caspase-3/7+ cells as well as apoptosis and necrosis on PANC-1 cells. Aspirin 0-7 caspase 3 Homo sapiens 53-64 32994805-7 2020 Further research showed that the anti-tumor effect of celecoxib combined with aspirin was mainly produced by activating caspase-9/caspase-3, arresting cell cycle and inhibiting the ERK-MAPK signaling pathway. Aspirin 78-85 caspase 3 Homo sapiens 130-139 26056043-6 2015 Metformin combined with aspirin significantly inhibited the phosphorylation of mTOR and STAT3, and induced apoptosis as measured by caspase-3 and PARP cleavage. Aspirin 24-31 caspase 3 Homo sapiens 132-141 30944660-0 2019 Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2. Aspirin 0-7 caspase 3 Homo sapiens 58-67 31014052-3 2019 Western blot was used to detect the expressions of microtubule-associated protein light chain 3 (LC3), p62 and cysteinyl aspartate specific proteinase 3 (caspase-3) after treatment with aspirin, metformin and 3-Methyladenine (3-MA). Aspirin 186-193 caspase 3 Homo sapiens 111-163 26711147-5 2016 In addition, ASA could led to a loss in the mitochondrial out membrane potential, up-regulate p53, phosphorylated p53 and Bax, down-regulate Bcl-2, release cytochrome c from the mitochondria to the cytoplasm, and activate caspase-9 and caspase-3 in A549 cells, which revealed that ASA could also induce apoptosis through the mitochondria mediated pathway. Aspirin 13-16 caspase 3 Homo sapiens 236-245 29805582-6 2018 Aspirin also significantly decreased the expression of B-cell lymphoma 2 (Bcl-2) and caspase-3, and increased the expression of Bcl-2-associated X protein, suggesting that aspirin induced apoptosis through the intrinsic apoptotic pathway. Aspirin 0-7 caspase 3 Homo sapiens 85-94 29805582-6 2018 Aspirin also significantly decreased the expression of B-cell lymphoma 2 (Bcl-2) and caspase-3, and increased the expression of Bcl-2-associated X protein, suggesting that aspirin induced apoptosis through the intrinsic apoptotic pathway. Aspirin 172-179 caspase 3 Homo sapiens 85-94 26844701-12 2016 Inhibition of COX-2 with aspirin or celecoxib did not affect Caspase-3 levels but also reduced Ki-67 and beta-Catenin levels, suggesting that Caspase-3 acted via COX-2 to stimulate cell proliferation and tissue regeneration. Aspirin 25-32 caspase 3 Homo sapiens 142-151 23611778-5 2013 We further showed that aspirin robustly enhanced Navitoclax-triggered cytosolic cytochrome c release, activation of initiator caspase-9 and effector caspase-3, and cleavage of PARP. Aspirin 23-30 caspase 3 Homo sapiens 149-158 23799623-8 2013 The antagonism of MTX efficacy caused by ASA was accompanied by altered expression of caspase-3, Bcl-2 and FAS but not dihydrofolate reductase (DHFR). Aspirin 41-44 caspase 3 Homo sapiens 86-95 23799623-9 2013 This suggests that the alteration of caspase-3, Bcl-2 and FAS was involved in the antagonism between ASA and MTX. Aspirin 101-104 caspase 3 Homo sapiens 37-46 23292806-0 2013 Direct regulation of caspase-3 by the transcription factor AP-2alpha is involved in aspirin-induced apoptosis in MDA-MB-453 breast cancer cells. Aspirin 96-103 caspase 3 Homo sapiens 21-30 23292806-5 2013 The present study reports that aspirin induces the apoptosis of MDA-MB-453 breast cancer cells which was attributed to the increased expression and activation of caspase-3. Aspirin 43-50 caspase 3 Homo sapiens 198-207 23292806-6 2013 Moreover, AP-2alpha, a transcription factor highly expressed in MDA-MB-453 cells, was identified as a negative regulator of caspase-3 transcription and AP-2alpha was attenuated following aspirin treatment. Aspirin 211-218 caspase 3 Homo sapiens 136-145 23292806-7 2013 Therefore, aspirin may increase the expression of caspase-3 by inducing the degradation of AP-2alpha, which increases activated caspase-3 expression, thereby triggering apoptosis in MDA-MB-453 cells. Aspirin 11-18 caspase 3 Homo sapiens 62-71 23292806-7 2013 Therefore, aspirin may increase the expression of caspase-3 by inducing the degradation of AP-2alpha, which increases activated caspase-3 expression, thereby triggering apoptosis in MDA-MB-453 cells. Aspirin 11-18 caspase 3 Homo sapiens 152-161 23301845-7 2013 To further confirm that aspirin incurs platelet apoptosis, caspase-3 activity was measured in platelets, and the result indicated that aspirin induced caspase-3 activation. Aspirin 24-31 caspase 3 Homo sapiens 59-68 23301845-7 2013 To further confirm that aspirin incurs platelet apoptosis, caspase-3 activity was measured in platelets, and the result indicated that aspirin induced caspase-3 activation. Aspirin 24-31 caspase 3 Homo sapiens 151-160 23301845-7 2013 To further confirm that aspirin incurs platelet apoptosis, caspase-3 activity was measured in platelets, and the result indicated that aspirin induced caspase-3 activation. Aspirin 135-142 caspase 3 Homo sapiens 59-68 23301845-7 2013 To further confirm that aspirin incurs platelet apoptosis, caspase-3 activity was measured in platelets, and the result indicated that aspirin induced caspase-3 activation. Aspirin 135-142 caspase 3 Homo sapiens 151-160 23301845-11 2013 Taken together, the data indicate that aspirin induces platelet apoptosis via caspase-3 activation. Aspirin 39-46 caspase 3 Homo sapiens 78-87 23404329-3 2013 Results demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose) polymerase (PARP) proteins. Aspirin 51-54 caspase 3 Homo sapiens 267-276