PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24760190-3	2014	We hypothesized that the effect of aspirin may be antagonized by low 15-PGDH expression in the normal colon.	Aspirin	35-42	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	69-76	
29552640-7	2017	Evidence also suggests that HPGD (15-PDGH) expression levels in normal colon and the germline rs6983267 polymorphism that relates to tumor CTNNB1 (beta-catenin)/WNT signaling status may predict the efficacy of aspirin for cancer chemoprevention.	Aspirin	210-217	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	28-32	
24760190-7	2014	Compared with nonuse, regular aspirin use was associated with lower risk of colorectal cancer that developed within a background of colonic mucosa with high 15-PGDH expression [multivariable HR, 0.49; 95% confidence interval (CI), 0.34 to 0.71], but not with low 15-PGDH expression (multivariable HR, 0.90; 95% CI, 0.63 to 1.27) (P for heterogeneity = 0.018).	Aspirin	30-37	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	157-164	
24760190-7	2014	Compared with nonuse, regular aspirin use was associated with lower risk of colorectal cancer that developed within a background of colonic mucosa with high 15-PGDH expression [multivariable HR, 0.49; 95% confidence interval (CI), 0.34 to 0.71], but not with low 15-PGDH expression (multivariable HR, 0.90; 95% CI, 0.63 to 1.27) (P for heterogeneity = 0.018).	Aspirin	30-37	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	263-270	
24760190-8	2014	Regular aspirin use was associated with lower incidence of colorectal cancers arising in association with high 15-PGDH expression, but not with low 15-PGDH expression in normal colon mucosa.	Aspirin	8-15	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	111-118	
24760190-9	2014	This suggests that 15-PGDH expression level in normal colon mucosa may serve as a biomarker that may predict stronger benefit from aspirin chemoprevention.	Aspirin	131-138	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	19-26	
23625286-8	2013	CONCLUSIONS: 15-PGDH levels vary across the population in a stable and reproducible manner, and are resistant to alteration by aspirin.	Aspirin	127-134	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	13-20	
34429873-6	2021	Additionally, high expression of the hydroxyprostaglandin dehydrogenase gene, HPGD encoding prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and low expression of the proteoglycan 2 gene, PRG2 encoding constituent of the eosinophil granule in sputum cells might serve as a predictor of good response to aspirin therapy.	Aspirin	333-340	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	78-82