PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26702643-0 2016 The Nonmetabolized beta-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3. Nadolol 32-39 POU class 2 homeobox 2 Homo sapiens 64-68 26702643-6 2016 In contrast, a significantly higher nadolol accumulation (at 1 and 10 muM) was found in OCT1, OCT2, MATE1, and MATE2-K cells compared to control cells (P < 0.01). Nadolol 36-43 POU class 2 homeobox 2 Homo sapiens 94-98 26702643-7 2016 Km values for OCT2-, MATE1-, and MATE2-K-mediated nadolol uptake were 122, 531, and 372 muM, respectively. Nadolol 50-57 POU class 2 homeobox 2 Homo sapiens 14-18 26702643-10 2016 In summary, nadolol is a substrate of the cation transporters OCT1, OCT2, MATE1, MATE2-K, and of P-gp. Nadolol 12-19 POU class 2 homeobox 2 Homo sapiens 68-72