PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29059199-8 2017 Among the beta-blockers, nadolol showed a significant risk reduction in both LQT1 and LQT2 (HR 0.47 and 0.27, respectively), whereas atenolol and propranolol decreased the risk only in LQT1 (HR 0.36 and 0.46, respectively). Nadolol 25-32 potassium voltage-gated channel subfamily H member 2 Homo sapiens 86-90 33611903-17 2021 Nadolol succeeded in eliminating cardiac events in one patient with LQT2 post ineffective metoprolol medication. Nadolol 0-7 potassium voltage-gated channel subfamily H member 2 Homo sapiens 68-72 33381033-5 2020 In conclusion, nadolol was recommended as a relatively effective strategy for LQT2 in order to improve the prognosis of patients during a long follow-up period. Nadolol 15-22 potassium voltage-gated channel subfamily H member 2 Homo sapiens 78-82 33304417-6 2020 This is the first report that demonstrates the efficacy and safety of trans-maternal administration of nadolol for treatment of symptomatic LQT2 fetuses with TdP. Nadolol 103-110 potassium voltage-gated channel subfamily H member 2 Homo sapiens 140-144 29059199-12 2017 Among them, nadolol was effective in LQT1 and LQT2, whereas other drugs showed different effectiveness depending on LQT genotype. Nadolol 12-19 potassium voltage-gated channel subfamily H member 2 Homo sapiens 46-50 34901807-1 2021 A novel frameshift mutation in the KCNH2 gene for long QT syndrome type 2 (LQTS2) was identified after torsades des pointes ventricular tachycardia in a 49-year-old patient managed with octreotide and nadolol for an acute variceal bleed. Nadolol 201-208 potassium voltage-gated channel subfamily H member 2 Homo sapiens 35-40 25257637-7 2014 In LQT1, the risk reduction for first cardiac events was similar among the 4 beta-blockers, but in LQT2, nadolol provided the only significant risk reduction (hazard ratio: 0.40 [0.16 to 0.98]). Nadolol 105-112 potassium voltage-gated channel subfamily H member 2 Homo sapiens 99-103 25257637-9 2014 CONCLUSIONS: Although the 4 beta-blockers are equally effective in reducing the risk of a first cardiac event in LQTS, their efficacy differed by genotype; nadolol was the only beta-blocker associated with a significant risk reduction in patients with LQT2. Nadolol 156-163 potassium voltage-gated channel subfamily H member 2 Homo sapiens 252-256