PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23419354-1 2013 The aim of the present study was to clarify the involvement of P-glycoprotein (P-gp) or organic anion transporting polypeptide (Oatp) 1a5 in the pharmacokinetics of nadolol (NDL), a non-metabolized hydrophilic beta-adrenoceptor blocker, in rats. Nadolol 165-172 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 63-77 23419354-1 2013 The aim of the present study was to clarify the involvement of P-glycoprotein (P-gp) or organic anion transporting polypeptide (Oatp) 1a5 in the pharmacokinetics of nadolol (NDL), a non-metabolized hydrophilic beta-adrenoceptor blocker, in rats. Nadolol 165-172 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 79-83 23419354-2 2013 Pretreatment with itraconazole (ICZ, P-gp inhibitor, 50 mg/kg) for 30 min before oral administration of NDL (10 mg/kg) significantly increased the area under the plasma concentration-time curve (AUC0- )of NDL by 1.7-fold compared with control. Nadolol 104-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 37-41 23419354-2 2013 Pretreatment with itraconazole (ICZ, P-gp inhibitor, 50 mg/kg) for 30 min before oral administration of NDL (10 mg/kg) significantly increased the area under the plasma concentration-time curve (AUC0- )of NDL by 1.7-fold compared with control. Nadolol 205-208 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 37-41